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'Adaptive' clinical trials now being planned at U-M, other sites

A new approach to testing medical treatment options could ensure that more patients get the most beneficial treatment for them - but still yield valuable research results that stand up to scientific scrutiny.

2 Jul 2012

Obese women draw the hypertension short straw

The associations of obesity with prehypertension and hypertension are stronger in women than men, a study suggests.

2 Jul 2012

Platelet activation linked to osteoporosis

Elderly, postmenopausal women with osteoporosis have elevated platelet volumes, report researchers.

2 Jul 2012

Procoagulant–fibrinolytic balance may predict hepatectomy thrombosis

An imbalance in procoagulant/fibrinolytic blood factors may point to an increased risk for thrombosis following liver surgery, research suggests.

2 Jul 2012

Study investigates association between SCC and cutaneous HPV types belonging to five different genera

Researchers at Moffitt Cancer Center and colleagues at the University of South Florida, the German Cancer Research Center in Heidelberg, and the International Agency for Research on Cancer in Lyon, France, conducted a case control study and found associations between having antibodies to certain types of cutaneous human papillomavirus (HPV) and a kind of skin cancer called squamous cell carcinoma (SCC).

2 Jul 2012

Abnormal bone marrow stem cells drive development of myelodysplastic syndromes

Researchers at Albert Einstein College of Medicine of Yeshiva University have found that abnormal bone marrow stem cells drive the development of myelodysplastic syndromes (MDS), serious blood diseases that are common among the elderly and that can progress to acute leukemia. The findings could lead to targeted therapies against MDS and prevent MDS-related cancers. The study is published today in the online edition of the journal Blood.

2 Jul 2012

Pediatric pain still common in hospitals

Despite advances in the understanding and treatment of pediatric pain, many hospitalized children continue to experience serious pain, according to a Johns Hopkins Children’s Center study published online ahead of print in the journal Pain Management Nursing.

2 Jul 2012

Teleflex PICC receives FDA 510(k) clearance for central venous pressure monitoring

Teleflex Incorporated, a leading global provider of medical devices for critical care and surgery, today announced its ArrowADVANTAGE5 pressure-injectable peripherally inserted central catheter (PICC) has received FDA 510(k) clearance for central venous pressure (CVP) monitoring indication.

2 Jul 2012

Safer alternative to experimental gene therapy against HIV infection

Scientists at The Scripps Research Institute have discovered a surprisingly simple and safe method to disrupt specific genes within cells. The scientists highlighted the medical potential of the new technique by demonstrating its use as a safer alternative to an experimental gene therapy against HIV infection.

2 Jul 2012

New treatment target against metastatic pancreatic cancer

Detailed analysis of genes expressed in circulating tumor cells (CTCs) -- cells that break off from solid tumors and travel through the bloodstream -- has identified a potential treatment target in metastatic pancreatic cancer.

2 Jul 2012

3D printed templates of filament networks can improve function of engineered living tissues

Researchers are hopeful that new advances in tissue engineering and regenerative medicine could one day make a replacement liver from a patient's own cells, or animal muscle tissue that could be cut into steaks without ever being inside a cow.

2 Jul 2012

Study illuminates key step in the journey of inflammation-producing immune cells

Like detectives seeking footprints and other clues on a television "whodunit," science can also benefit from analyzing the tracks of important players in the body's molecular landscape. Klaus Ley, M.D., a scientist at the La Jolla Institute for Allergy & Immunology, has done just that and illuminated a key step in the journey of inflammation-producing immune cells.

2 Jul 2012

Clinical results for Teva's biologic oncology candidates presented at MASCC/ISOO 2012

Teva Pharmaceutical Industries Ltd. announced today the presentation of clinical results for its biologic oncology candidates, lipegfilgrastim and balugrastim, at the Multinational Association of Supportive Care in Cancer (MASCC)/International Society of Oral Oncology (ISOO) 2012 International Symposium on Supportive Care in Cancer being held in New York June 28-30.

2 Jul 2012

New volumetric functional MRI scan figures out beneficiaries of chemotherapy in liver cancer patients

Studies on some 55 U.S. men and women with potentially deadly liver or pancreatic cancers show that specialized MRI scans can tell within a month whether highly toxic chemotherapy is working and killing tumor cells long before tumors actually shrink - or fail to shrink.

2 Jul 2012

Under-performance of small bowel biopsy a major reason behind underdiagnosis of celiac disease

Under-performance of small bowel biopsy during endoscopy may be a major reason that celiac disease remains underdiagnosed in the United States, according to a new study published online recently in Gastrointestinal Endoscopy. Investigators at the Celiac Disease Center at Columbia University Medical Center (CUMC) found that the rate of small bowel biopsy is low in this country.

30 Jun 2012

New toxicology testing method requires lesser number of fish

A new way of testing the safety of natural and synthetic chemicals has been developed by scientists with funding from the Biotechnology and Biological Sciences Research Council (BBSRC). Their research, published today in the journal Ecotoxicology, could reduce the number of fish needed to test the toxicity of a range of chemicals including pharmaceuticals and environmental pollutants.

30 Jun 2012

Textile cooling pads to prevent neurological damage after successful resuscitation

Textile cooling pads are to be used in future to prevent neurological damage after successful resuscitation. The system developed by scientists from the Hohenstein Institute in Bönnigheim requires no electric power, making it ideal especially for first aid in case of cardiac arrest.

30 Jun 2012

Severe sleep loss jolts the immune system into action

Severe sleep loss jolts the immune system into action, reflecting the same type of immediate response shown during exposure to stress, a new study reports.

30 Jun 2012

Bees help understand connection between taste perception and metabolic syndromes

Scientists at Arizona State University have discovered that honey bees may teach us about basic connections between taste perception and metabolic disorders in humans. By experimenting with honey bee genetics, researchers have identified connections between sugar sensitivity, diabetic physiology and carbohydrate metabolism. Bees and humans may partially share these connections.

30 Jun 2012

Rate of small bowel biopsy is low in the U.S.

30 Jun 2012

Blood News and Research

'Adaptive' clinical trials now being planned at U-M, other sites

Obese women draw the hypertension short straw

Platelet activation linked to osteoporosis

Procoagulant–fibrinolytic balance may predict hepatectomy thrombosis

Study investigates association between SCC and cutaneous HPV types belonging to five different genera

Abnormal bone marrow stem cells drive development of myelodysplastic syndromes

Pediatric pain still common in hospitals

Teleflex PICC receives FDA 510(k) clearance for central venous pressure monitoring

Safer alternative to experimental gene therapy against HIV infection

New treatment target against metastatic pancreatic cancer

3D printed templates of filament networks can improve function of engineered living tissues

Study illuminates key step in the journey of inflammation-producing immune cells

Clinical results for Teva's biologic oncology candidates presented at MASCC/ISOO 2012

New volumetric functional MRI scan figures out beneficiaries of chemotherapy in liver cancer patients

Under-performance of small bowel biopsy a major reason behind underdiagnosis of celiac disease

New toxicology testing method requires lesser number of fish

Textile cooling pads to prevent neurological damage after successful resuscitation

Severe sleep loss jolts the immune system into action

Bees help understand connection between taste perception and metabolic syndromes

Rate of small bowel biopsy is low in the U.S.

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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