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Subjective cognitive decline predicts future dementia risk, study finds

A study in JAMA Psychiatry finds that subjective cognitive decline (SCD) significantly predicts the risk of mild cognitive impairment (MCI), Alzheimer's disease (AD), and all-cause dementia in older adults.

7 Jul 2024

Machine learning identifies cancer-driving mutations at CTCF binding sites

Researchers developed a machine learning tool, CTCF-INSITE, to identify mutational hotspots at persistent CTCF binding sites across various cancers, highlighting their role in genomic structure disruption and cancer progression.

7 Jul 2024

Novel antiviral protein SAMD9L blocks HIV-1 and other lentiviruses

Researchers discovered that interferon-stimulated SAMD9L restricts HIV-1 and other lentiviruses by inhibiting viral translation and endosomal trafficking, while SAMD9 enhances HIV-1 replication.

7 Jul 2024

Targeted vitamin D supplementation may lower depression risk for deficient individuals, study finds

Targeted vitamin D supplementation for those with low levels can reduce the risk of depression, but shows no significant impact on chronic pain or other conditions.

7 Jul 2024

Phages use selfish DNA to outmaneuver competitors

Curious bits of DNA tucked inside genomes across all kingdoms of life historically have been disregarded since they don't seem to have a role to play in the competition for survival.

5 Jul 2024

Experts produce consensus statement on sex and gender disparities in resilience to Alzheimer's

An international panel of experts led by the Barcelona Institute for Global Health (ISGlobal), a centre supported by the "la Caixa" Foundation, under the umbrella of the Alzheimer's Association International Society to Advance Alzheimer's Research and Treatment, has produced a consensus statement on sex and gender disparities in resilience to Alzheimer's disease and call for incorporating these differences in future research.

5 Jul 2024

Scientists map all the possible outcomes of changes to key tumor-suppressing gene

Researchers at the Francis Crick Institute have mapped all the possible outcomes of changes to a tumor-suppressing gene called VHL, the first step in a huge research endeavor to unpick the outcomes of tens of thousands of genetic variations in genes associated with cancer.

5 Jul 2024

Why do aortic aneurysms form in specific locations?

The sites where vascular aneurysms typically form have a predilection from the outset, even in healthy people. This is shown by a study conducted by medical researchers from Bochum and Bonn.

5 Jul 2024

DNA repair mutations act as a switch for bowel cancer

Bowel cancer cells have the ability to regulate their growth using a genetic on-off switch to maximize their chances of survival, a phenomenon that's been observed for the first time by researchers at UCL and University Medical Center Utrecht.

5 Jul 2024

Biomarkers of food intake: The key to precision nutrition

Researchers examine the potential utility of biomarkers of food intake on objective and accurate dietary assessments.

5 Jul 2024

Researchers discover rare types of helper T cells associated with immune disorders

Researchers led by Yasuhiro Murakawa at the RIKEN Center for Integrative Medical Sciences (IMS) and Kyoto University in Japan and IFOM ETS in Italy have discovered several rare types of helper T cells that are associated with immune disorders such as multiple sclerosis, rheumatoid arthritis, and even asthma.

4 Jul 2024

Turning cancer cells against themselves to overcome drug resistance

Treating cancer can sometimes feel like a game of Whac-A-Mole. The disease can become resistant to treatment, and clinicians never know when, where and what resistance might emerge, leaving them one step behind.

4 Jul 2024

More than 1,000 small changes in DNA identified that influence age of first period

Researchers examined nearly 800,000 women's DNA to explore puberty timing complexities. They identified signals related to menarche timing and investigated their influence on puberty onset.

4 Jul 2024

Disturbances in sleep patterns increase the risk of depression in midlife women

The relationship between sleep-wake changes and depressive symptoms among midlife women.

4 Jul 2024

Healthy lifestyle can overcome genetic risk of obesity, new study reveals

Study demonstrates that adherence to a healthy lifestyle can significantly mitigate the genetic risk of obesity and its related morbidities, emphasizing the importance of promoting healthy behaviors irrespective of genetic predisposition.

4 Jul 2024

Decoding cerebellar neural patterns in movement disorders

The cerebellum is a region of the brain that helps us refine our movements and learn new motor skills.

3 Jul 2024

Mapping pathogen spread and evolution using genomic and human mobility data

A new way to map the spread and evolution of pathogens, and their responses to vaccines and antibiotics, will provide key insights to help predict and prevent future outbreaks.

3 Jul 2024

New guidelines provide the first code of practice for use of stem cell-based embryo models

Stem cell-based embryo models (SCBEMs) are three-dimensional biological structures that mimic aspects of early human embryo development.

3 Jul 2024

Machine learning revolutionizes cardiac studies in fruit flies

Drosophila - commonly known as fruit flies - are a valuable model for human heart pathophysiology, including cardiac aging and cardiomyopathy.

3 Jul 2024

Protein nanocages: A promising frontier in mRNA therapeutics

In recent years, messenger RNA (mRNA) has emerged as a promising avenue for accurate and potent therapeutic interventions. Unlike DNA drugs, mRNA can express genetic information without the risk of integrating into the host genome.

3 Jul 2024