Protein News and Research

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Proteins are complex molecules that are made up of amino acids. They can be found in every cell in the body, and carry out vital processes that keep human beings alive. Mutations in proteins can lead to a multitude of diseases, the most common being cancer.

Experts on chronic lymphocytic leukemia (CLL) review current scientific knowledge

When the most common adult leukemia in the United States was last reviewed by the New England Journal of Medicine (NEJM) in 1995, it was seen through the eyes of theories that dated back to the 1960s.

24 Feb 2005

Protein called CK2 plays a deadly role in colorectal carcinoma

A protein called CK2 plays a deadly role in colorectal carcinoma by blocking the ability of these tumors to activate a natural self-destruct mechanism that would clear this cancer from the body. This finding, by researchers at St. Jude Children's Research Hospital, is currently published in the online edition of Oncogene.

24 Feb 2005

Discovery could lead to the prevention, and possibly treatment of autoimmune diseases such as Type 1 diabetes

Scientists at the University of Maryland School of Medicine in Baltimore have identified a way to prevent Type I diabetes in rats that are genetically prone to develop the disease.

23 Feb 2005

Researchers identify target for cancer drugs

For nearly a decade, scientists have been trying to fully understand a particular communication pathway inside of cells that contributes to many malignant brain and prostate cancers. While scientists have identified elements of this pathway, other key components have remained a mystery.

23 Feb 2005

New information that may help guide design of vaccines for HIV-1

Scientists have uncovered new information that may help guide design of vaccines for HIV-1, the virus that causes AIDS. A new detailed structural analysis of the complex formed by an anti-HIV antibody called 4E10 and its specific target provides insight into why this particular antibody is so broadly effective, a rare characteristic for HIV discovered thus far.

22 Feb 2005

Research shows preventive effects of cannabinoids on Alzheimer's disease

New research shows that a synthetic analogue of the active component of marijuana may reduce the inflammation and prevent the mental decline associated with Alzheimer's disease.

22 Feb 2005

Antibody that neutralizes most HIV strains

A group of scientists from The Scripps Research Institute and several other institutions has solved the structure of a rare human antibody that broadly neutralizes human immunodeficiency virus (HIV), which causes acquired immunodeficiency syndrome (AIDS).

22 Feb 2005

Researchers have identified a protein called HIF-2a, which is important in retina formation

Hoping to prevent blindness in premature babies, UT Southwestern Medical Center researchers have identified a protein that responds to oxygen levels in cells and tissues and also affects the developing eye.

22 Feb 2005

Lack of magnesium in diet linked to disease

The Gordon Research International Conference on Magnesium was held during the second week in February in Ventura, California, to discuss the research findings on the links between deficiencies in the mineral magnesium and a host of life-threatening diseases, including heart disease and arteriosclerosis.

22 Feb 2005

Dietary protein and bone health revisited

Agricultural Research Service (ARS) scientists first compared high-meat protein diets with low-meat protein diets. Now, they've compared animal-protein diets with vegetable-protein diets. This "sequel" study rocks the foundation, again, of a commonly held belief that high-protein diets can be bad for bones.

22 Feb 2005

Differing forms of taste genes mean that we all live in our own unique taste world

A study published in the February 22 issue of Current Biology confirms the influential role of genetics in determining the wide range of human sensitivity to taste, ultimately impacting how we each perceive the world in a slightly different way.

22 Feb 2005

Secreted signaling protein called Wnt10b secret to new drugs for preventing or treating osteoporosis

Leaping tall buildings in a single bound may be out of the question, but the genetically engineered "supermice" in Ormond MacDougald's laboratory at the University of Michigan Medical School are definitely stronger than average.

22 Feb 2005

Diagnosis of prions in patients should utilize novel strategy, conformation-dependent immunoassay

A technique for detecting prions in tissue, developed in recent years by UCSF scientists, is significantly more sensitive than the diagnostic procedures currently used to detect the lethal particles in samples of brain tissue from patients, according to a study performed by a UCSF team.

22 Feb 2005

Why some lung cancers stop responding to the drugs erlotinib (Tarceva) and gefitinib (Iressa)

Researchers at Memorial Sloan-Kettering Cancer Center (MSKCC) have found an explanation for why some lung cancers stop responding to the drugs erlotinib (Tarceva) and gefitinib (Iressa).

22 Feb 2005

New compound, AMN107, 20 times more potent than Gleevec for chronic myelogenous leukemia treatment

A laboratory study led by researchers at Dana-Farber Cancer Institute has shown that a potent and highly selective therapy for chronic myelogenous leukemia (CML) may ultimately be more effective than Gleevec®, the current standard of care.

21 Feb 2005

New clues to amyloidoses

Familial amyloid polyneuropathy (FAP), a hereditary disease characterised by abnormal deposits of insoluble protein in the organs, results from a mutation in a single gene (the transthyretin or TTR gene). Nevertheless, disease incidence and age of onset can vary significantly between patients what have always puzzled scientists.

21 Feb 2005

New findings on the regulation of cellular growth

A greatly increased synthesis of new proteins is one of the first and most important events that occur in both normal and tumour cells upon growth stimulation.

21 Feb 2005

Lack of collagen increases likelihood of osteoarthritis

Duke University Medical Center researchers have found that joints whose cartilage lacks a specific type of collagen will develop osteoarthritis – the so-called "wear-and-tear" form of the disease – at a greatly accelerated rate.

20 Feb 2005

Vaccine that boosts the immune response could improve the effect of conventional treatment for patients with chronic myeloid leukaemia

CML is caused by the breakage and swapping of chromosomes 9 and 22, which results in a shortened chromosome called the Philadelphia chromosome. Cells with the abnormal chromosome make a protein that encourages aberrant growth and division. Patients with CML can be treated with a drug called imatinib or interferon alfa.

20 Feb 2005

Shedding new LIGHT on disease

New drugs for the 270,000 people who suffer heart attacks every year in the UK will be among the projects in Leeds' new research institute. The Leeds Institute of Genetics Health and Therapeutics (LIGHT) was opened by head of the Medical Research Council chief executive Professor Colin Blakemore yesterday.

17 Feb 2005

Protein News and Research

Further Reading

Experts on chronic lymphocytic leukemia (CLL) review current scientific knowledge

Protein called CK2 plays a deadly role in colorectal carcinoma

Discovery could lead to the prevention, and possibly treatment of autoimmune diseases such as Type 1 diabetes

Researchers identify target for cancer drugs

New information that may help guide design of vaccines for HIV-1

Research shows preventive effects of cannabinoids on Alzheimer's disease

Antibody that neutralizes most HIV strains

Researchers have identified a protein called HIF-2a, which is important in retina formation

Lack of magnesium in diet linked to disease

Dietary protein and bone health revisited

Differing forms of taste genes mean that we all live in our own unique taste world

Secreted signaling protein called Wnt10b secret to new drugs for preventing or treating osteoporosis

Diagnosis of prions in patients should utilize novel strategy, conformation-dependent immunoassay

Why some lung cancers stop responding to the drugs erlotinib (Tarceva) and gefitinib (Iressa)

New compound, AMN107, 20 times more potent than Gleevec for chronic myelogenous leukemia treatment

New clues to amyloidoses

New findings on the regulation of cellular growth

Lack of collagen increases likelihood of osteoarthritis

Vaccine that boosts the immune response could improve the effect of conventional treatment for patients with chronic myeloid leukaemia

Shedding new LIGHT on disease

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