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Novel insights into the genetics of autism

A study of 2,377 children with autism, their parents and siblings has revealed novel insights into the genetics of the condition.

12 May 2015

Brain protein plays key role in controlling binge drinking

Scientists at The Scripps Research Institute have discovered that a brain protein has a key role in controlling binge drinking in animal models. They found that deleting the gene for this protein in mice ramped up alcohol consumption and prevented the brain from signaling the rewarding properties of alcohol.

12 May 2015

TSRI scientists map out protein structure involved in cellular function, nervous system development

Scientists from The Scripps Research Institute, working closely with researchers at the National Institutes of Health, have mapped out the structure of an important protein involved in cellular function and nervous system development.

12 May 2015

New Johns Hopkins-led research suggests risk factors for developing acute kidney injury

Physicians treating hospitalized patients for conditions unrelated to the kidneys should pay close attention to common blood and urine tests for kidney function in order to prevent incidental injury to the organs that help cleanse the body of toxins, new Johns Hopkins Bloomberg School of Public Health-led research suggests.

12 May 2015

Discovery paves way for developing treatments for people addicted to cocaine, amphetamines

In a major advance in the field of neuropsychiatry, researchers in the Vollum Institute at Oregon Health & Science University have illuminated how cocaine and amphetamines disrupt the normal functioning of the dopamine transporter in the brain.

12 May 2015

Experimental gene therapy holds promise against metastatic prostate cancer

Even with the best available treatments, the median survival of patients with metastatic, hormone-refractory prostate cancer is only two to three years. Driven by the need for more effective therapies for these patients, researchers at VCU Massey Cancer Center and the VCU Institute of Molecular Medicine have developed a unique approach that uses microscopic gas bubbles to deliver directly to the cancer a viral gene therapy in combination with an experimental drug that targets a specific gene driving the cancer's growth.

12 May 2015

Dana-Farber/Boston Children's joins immunotherapy clinical trial for children with ALL

Dana-Farber/Boston Children's Cancer and Blood Disorders Center has joined a clinical trial of immunotherapy for children with relapsed or treatment-resistant acute lymphoblastic leukemia (ALL). Led by Memorial Sloan Kettering Cancer Center, the trial is one of several nationally that are evaluating cancer immunotherapy, a treatment approach -- hailed by Science magazine as their Breakthrough of the Year in 2013 -- that triggers a patient's immune system to attack his or her cancer cells.

11 May 2015

Scientists identify gene that causes hereditary hypertension and brachydactyly type E

Individuals with this altered gene have hereditary hypertension (high blood pressure) and at the same time a skeletal malformation called brachydactyly type E, which is characterized by unusually short fingers and toes. The effect on blood pressure is so serious that -- if left untreated -- it most often leads to death before age fifty.

11 May 2015

Panacea Pharmaceuticals selects Goodwin to complete novel vaccine Fill / Finish project

Goodwin Biotechnology, Inc., a biological Contract Development and Manufacturing Organization that specializes in bioprocess development and GMP manufacturing of biopharmaceuticals utilizing Mammalian Cell Culture expression systems and Bioconjugation technologies, was selected by Panacea Pharmaceuticals, Inc. to complete a novel Fill / Finish project, as well as Quality Control release and stability testing for a therapeutic, nanoparticle cancer vaccine based on the Human Aspartyl (Asparaginyl) β-Hydroxylase (HAAH) tumor-specific protein to support Phase I clinical trials in patients with various solid tumor cancers.

11 May 2015

Overview of Blueprint Medicines' kinase drug discovery strategy published in JCI

Blueprint Medicines today announced that the Journal of Clinical Investigation published an overview of the Company's kinase drug discovery and development strategy. The publication underscores Blueprint Medicines' focus on identifying novel genomically defined disease drivers and the use of novel chemistry from its proprietary compound library to craft highly selective kinase inhibitors for new and difficult-to-drug kinase targets.

11 May 2015

MJFF announces acquisition of parkin research tools from Imago Pharmaceuticals

The Michael J. Fox Foundation for Parkinson's Research announces the acquisition of a library of research tools around the parkin protein from Imago Pharmaceuticals. The Foundation believes these tools — cell lines, plasmids, compounds and more — will accelerate biological study and drug development against this promising disease-modification target.

11 May 2015

Researchers discover potential mechanism to combat haemorrhagic diseases

A potential mechanism to combat diseases caused by haemorrhagic fever viruses has been discovered by researchers at the University of Montreal's Department of Biochemistry and Molecular Medicine. These diseases present a dramatic risk to human health as they often spread quickly and kill a high percentage of infected individuals, as demonstrated by the recent Ebola outbreaks.

11 May 2015

Study finds link between PTSD and accelerated aging

In recent years, public health concerns about post-traumatic stress disorder (PTSD) have risen significantly, driven in part by affected military veterans returning from conflicts in the Middle East and elsewhere. PTSD is associated with number of psychological maladies, among them chronic depression, anger, insomnia, eating disorders and substance abuse.

10 May 2015

Study sheds light on developing more targeted therapies against medulloblastoma

St. Jude Children's Research Hospital scientists have gained ground toward developing more targeted therapies for the most common childhood brain tumor.

10 May 2015

Researchers identify promising combination strategy for treating glioblastomas

Therapies that specifically target mutations in a person's cancer have been much-heralded in recent years, yet cancer cells often find a way around them. To address this, researchers at University of California, San Diego School of Medicine and Moores Cancer Center identified a promising combinatorial approach to treating glioblastomas, the most common form of primary brain cancer.

10 May 2015

β-amyloid deposition highly variable in synucleinopathy

A meta-analysis suggests large variability in the prevalence of β-amyloid deposition in patients with synucleinopathies.

8 May 2015

Scripps Florida scientists win $2.4 million to expand development of new pain therapies

Scientists from the Florida campus of The Scripps Research Institute (TSRI) have been awarded $2.4 million from the National Institute on Drug Abuse of The National Institutes of Health to expand development of new pain medications with fewer side effects than those currently available...

8 May 2015

Danish researchers discover way to map more than one protein at a time

Danish researchers at the University of Copenhagen have discovered how to map more than one protein at a time, when proteins repair damaged DNA. It is a discovery that will help accelerate the process of developing better and gentler cancer treatments.

8 May 2015

Discovery opens up new avenue for development of potential therapies to treat, prevent malaria

Scientists have identified a protein on the surface of human red blood cells that serves as an essential entry point for invasion by the malaria parasite. This discovery opens up a promising new avenue for the development of therapies to treat and prevent malaria.

8 May 2015

Knowing the physical structure of amyloid beta-42 offers new view on amyloid propagation in Alzheimer's

Researchers at the University of Illinois at Chicago have determined the molecular structure of one of the proteins in the fine fibers of the brain plaques that are a hallmark of Alzheimer's disease. This molecule, called amyloid beta-42, is toxic to nerve cells and is believed to provoke the disease cascade.

8 May 2015

G Protein News and Research

Novel insights into the genetics of autism

Brain protein plays key role in controlling binge drinking

TSRI scientists map out protein structure involved in cellular function, nervous system development

New Johns Hopkins-led research suggests risk factors for developing acute kidney injury

Discovery paves way for developing treatments for people addicted to cocaine, amphetamines

Experimental gene therapy holds promise against metastatic prostate cancer

Dana-Farber/Boston Children's joins immunotherapy clinical trial for children with ALL

Scientists identify gene that causes hereditary hypertension and brachydactyly type E

Panacea Pharmaceuticals selects Goodwin to complete novel vaccine Fill / Finish project

Overview of Blueprint Medicines' kinase drug discovery strategy published in JCI

MJFF announces acquisition of parkin research tools from Imago Pharmaceuticals

Researchers discover potential mechanism to combat haemorrhagic diseases

Study finds link between PTSD and accelerated aging

Study sheds light on developing more targeted therapies against medulloblastoma

Researchers identify promising combination strategy for treating glioblastomas

β-amyloid deposition highly variable in synucleinopathy

Scripps Florida scientists win $2.4 million to expand development of new pain therapies

Danish researchers discover way to map more than one protein at a time

Discovery opens up new avenue for development of potential therapies to treat, prevent malaria

Knowing the physical structure of amyloid beta-42 offers new view on amyloid propagation in Alzheimer's

Industry Focus eBook - Cell biology (5th edition) eBook

How ELRIG Is Helping Mid-Career Scientists Navigate Leadership, Career Change and Redundancy

The role of UV-Vis in biopharma QC

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