Therapy News and Research

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Preclinical antitumor efficacy evaluation of dendrimer-based methotrexate conjugates

Although a variety of nanoparticles continue to show promise for improving cancer imaging and therapy, regulators and drug developers are concerned that these delivery systems may prove difficult to manufacture on a consistent basis, which is key for any agent designed for use in humans.

3 Mar 2008

Fluorescent nanoparticles image tumor marker in animals

Since 2004 the U.S. Food and Drug Administration has approved three new-generation anticancer therapies that target epidermal growth factor receptor (EGFR), a protein that is greatly overexpressed on certain types of tumors, including some forms of colorectal and lung cancer.

3 Mar 2008

Gold nanoparticle-based colorimetric assay for the direct detection of cancerous cells

Early detection of tumors is one of the Holy Grails of cancer research, an achievement that would greatly improve cancer therapy and prognosis. Two new reports describe different but promising approaches to solving this problem.

3 Mar 2008

National Institute for Health and Clinical Excellence (NICE) releases appraisal consultation document on treatment of pulmonary arterial hypertension in adults

The National Institute for Clinical Excellence (NICE) has published on its website the preliminary recommendations of its Appraisal Committee on the use of epoprostenol, iloprost, bosentan, sitaxentan and sildenafil for the treatment of pulmonary hypertension in adults.

3 Mar 2008

1 in 3 women has pelvic floor disorder

A new study by Kaiser Permanente found that one-third of women suffer from one or more pelvic floor disorders, which include symptoms such as the frequent urge to urinate, dropped pelvic organs, and incontinence.

3 Mar 2008

FDA approves PRISTIQ for the treatment of adult patients with major depressive disorder

Wyeth Pharmaceuticals, a division of Wyeth, has announced that the U.S. Food and Drug Administration (FDA) has approved PRISTIQ (desvenlafaxine), a structurally novel, once-daily serotonin-norepinephrine reuptake inhibitor (SNRI), to treat adult patients with major depressive disorder (MDD).

3 Mar 2008

Clinical trial shows reduction in mortality for children with severe Langerhans cell histiocytosis

A new international study finds that introducing an increased intensity of chemotherapy in children with severe Langerhans cell histiocytosis (LCH) can reduce the mortality rate for this disorder by as much as 20 percent when the patient demonstrates a rapid response to such treatment.

3 Mar 2008

Arsenic used to label antibodies for the detection of tumors

Arsenic linked to a drug that binds to the blood vessels of cancerous tumors provides a powerful imaging agent that could one day allow physicians to detect hard-to-find tumors and more closely monitor cancer's response to therapy, researchers at UT Southwestern Medical Center have found.

3 Mar 2008

Researchers investigate predictors for sickle-cell-anemia complications

Researchers at UT Southwestern Medical Center have determined that the level, or saturation, of oxygen in blood could be used to identify children with sickle cell anemia who are at an increased risk of stroke.

1 Mar 2008

Killing cancer tumors with Salmonella bacteria

Neil Forbes of the University of Massachusetts Amherst has received a four-year grant of more than $1 million from the National Institutes of Health to research killing cancer tumors with Salmonella bacteria.

1 Mar 2008

New global study of targeted therapies for breast cancer

Two targeted medications designed to treat an aggressive form of breast cancer are being tested in a new study involving 8,000 participants in 50 countries across six continents -- a clinical trial that investigators hope will provide a new model for global cancer research.

1 Mar 2008

Low-fat better than low-carb diets for heart health

Low-fat diets are more effective in preserving and promoting a healthy cardiovascular system than low-carbohydrate, Atkins'-like diets, according to a new study by researchers at the Medical College of Wisconsin in Milwaukee.

1 Mar 2008

Intensive insulin therapy may be harmful to the critically ill

Doubt has been cast over the current practice of administering intensive insulin therapy to all critically ill patients, according to a study published this week in the open access journal Critical Care. In certain groups of patients it could even be harmful.

1 Mar 2008

Profound financial life changes plague families of children with autism

The information that a child has been diagnosed with autism often throws parents into an emotional tailspin.

1 Mar 2008

Customized treatments for sepsis lower treatment time and reduce length of ICU stays

Using a blood test and a decision algorithm, rather than standard hospital protocols, to determine the appropriate length of antibiotic therapy in patients with severe sepsis or septic shock can reduce duration of treatments, shorten ICU stays, and lower hospital costs - all without adverse effects on patients, according to new research.

1 Mar 2008

AstraZeneca submits sNDA for SEROQUEL XR for treatment of major depressive disorder

AstraZeneca has announced the submission of a supplemental New Drug Application (sNDA) to the U.S. Food and Drug Administration (FDA) for once- daily SEROQUEL XR (quetiapine fumarate) Extended-Release Tablets to seek approval for the treatment of major depressive disorder (MDD) as monotherapy, adjunct therapy, and maintenance therapy in adult patients.

1 Mar 2008

Abilify (aripiprazole) approved for acute treatment of bipolar I disorder in adolescents

Otsuka Pharmaceutical Co., Ltd. and Bristol-Myers Squibb Company has announced that the U.S. Food and Drug Administration (FDA) approved the supplemental New Drug Application for ABILIFY (aripiprazole) for the acute treatment of manic and mixed episodes associated with Bipolar I Disorder, with or without psychotic features in pediatric patients (10 to 17 years old).

1 Mar 2008

Therapy News and Research

Preclinical antitumor efficacy evaluation of dendrimer-based methotrexate conjugates

Fluorescent nanoparticles image tumor marker in animals

Gold nanoparticle-based colorimetric assay for the direct detection of cancerous cells

National Institute for Health and Clinical Excellence (NICE) releases appraisal consultation document on treatment of pulmonary arterial hypertension in adults

1 in 3 women has pelvic floor disorder

FDA approves PRISTIQ for the treatment of adult patients with major depressive disorder

Clinical trial shows reduction in mortality for children with severe Langerhans cell histiocytosis

Arsenic used to label antibodies for the detection of tumors

Researchers investigate predictors for sickle-cell-anemia complications

Killing cancer tumors with Salmonella bacteria

New global study of targeted therapies for breast cancer

Low-fat better than low-carb diets for heart health

Intensive insulin therapy may be harmful to the critically ill

Profound financial life changes plague families of children with autism

Customized treatments for sepsis lower treatment time and reduce length of ICU stays

AstraZeneca submits sNDA for SEROQUEL XR for treatment of major depressive disorder

Abilify (aripiprazole) approved for acute treatment of bipolar I disorder in adolescents

Glioblastoma multiforme responds to new treatment

Hydroxyurea for sickle cell patients

Music may help ease symptoms of depression

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

The impact of vibration on microscopy

How Omics Technologies Are Transforming Biological Research and Drug Discovery

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