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New microfluidic biosensor can identify white blood cells quickly for AIDS diagnosis

Researchers from the University of Illinois at Urbana-Champaign have developed a highly sensitive biosensor based on a differential immuno-capture technology that can detect sub-populations of white blood cells. As part of a small, disposable biochip, the microfluidic biosensor can count CD4+/CD8+ T cells quickly and accurately for AIDS diagnosis in the field.

14 Mar 2016

Researchers uncover antitumoral nature of maslinic acid in colon cancer cells

Researchers from the University of Granada, in collaboration with the universities of Barcelona and Jaen, have brought to light the antitumoral nature of maslinic acid (a compound derived from olives) in Caco-2 p53-deficient colon adenocarcinoma cells in the short term.

11 Mar 2016

CWRU researcher to customize tobacco mosaic virus to treat human cancers

A Case Western Reserve University researcher has been awarded more than $3 million in federal and foundation grants to turn common plant viruses into cancer sleuths and search-and-destroy emissaries.

10 Mar 2016

New, regenerative medicine approach developed to remove congenital cataracts in infants

Researchers at University of California, San Diego School of Medicine and Shiley Eye Institute, with colleagues in China, have developed a new, regenerative medicine approach to remove congenital cataracts in infants, permitting remaining stem cells to regrow functional lenses.

10 Mar 2016

MGH researchers identify how Shigella injects proteins into target host cells

Researchers from the Massachusetts General Hospital Division of Infectious Diseases are investigating the mechanism by which several important pathogenic species of bacteria deliver proteins into the cells of the organisms they are infecting.

10 Mar 2016

Novel nanoparticle technology can decipher protein structures and help access drug targets

Researchers at Karolinska Institutet, Sweden, have developed a nanoparticle technology that can be used to stabilise membrane proteins so that their structure can be studied in a lipid environment. The method, described in Nature Methods, makes it possible to access drug targets that previously could not be investigated and therefore potentially allows for the development of novel drugs, therapeutic antibodies and vaccines.

9 Mar 2016

Absence of PEMT enzyme leads to development of fatty liver disease and tumours in thin patients

Researchers observe protection against obesity and insulin resistance but at the cost of prominent fatty liver disease in mice lacking the PEMT enzyme and patients with low levels of PEMT.

7 Mar 2016

Researchers uncover new pathway for mitochondrial cell death

Researchers at St. Jude Children's Research Hospital have uncovered a new pathway for mitochondrial cell death that involves the protein BCL-2 ovarian killer, otherwise known as BOK. The discovery, which is described online in the journal Cell, may lead to new ways to trigger cell death in some types of cancer cells.

4 Mar 2016

Study provides critical insight into Warburg effect

PGK1, a glycolytic enzyme, has been found to play a role in coordinating cellular processes crucial to cancer metabolism and brain tumor formation, according to results published in today's online issue of Molecular Cell. The findings may lay the groundwork for improved approaches to diagnosis and treatment of glioblastoma and other cancers.

4 Mar 2016

Researchers reveal link between mitochondrial dysfunction and Fuchs' Endothelial Corneal Dystrophy

Researchers at Schepens Eye Research Institute of Massachusetts Eye and Ear have shown a link between mitochondrial dysfunction in corneal endothelial cells and the development of Fuchs' Endothelial Corneal Dystrophy.

4 Mar 2016

Researchers aim to develop gentler treatment that 'tricks' cancer cells

The most common treatments for cancer are radiation and chemotherapy. However they have side effects and also damage healthy tissues. Moreover, their effectiveness is limited when the cancer has spread through out the body. Researchers at the Niels Bohr Institute are therefore working to develop a gentler treatment that 'tricks' the cancer cells, which would absorb a cytotoxin and therefore be destroyed, while healthy cells would remain unaffected. The results are published in the scientific journal, Scientific Reports.

2 Mar 2016

Study provides insights into cellular mechanisms that may contribute to new osteoarthritis treatments

Researchers show that the protein CCN4 positively regulates the generation of cartilage matrix, which are depleted in osteoarthritis.

2 Mar 2016

Depression may be a systemic disease, say researchers

An international team of researchers lead by the University of Granada has scientifically proven, for the first time, that depression is associated with important alterations of the oxidative stress, so it should be considered a systemic disease.

2 Mar 2016

Added benefit of aflibercept not proven in myopic choroidal neovascularisation

Aflibercept (trade name: Eylea) has been approved since October 2015 for adults with impaired vision due to myopic choroidal neovascularisation.

2 Mar 2016

Polyunsaturated lipids can alter binding rate of two receptors involved in Parkinson's and Alzheimer's

A study published in the prestigious journal Scientific Reports from the Nature group demonstrates, for the first time and using computational tools, that polyunsaturated lipids can alter the binding rate of two types of receivers involved in certain nervous system diseases.

2 Mar 2016

Cryo-electron microscopy helps analyze infection mechanisms of coronaviruses in detail

High-resolution cryo-electron microscopy and supercomputing have now made it possible to analyze in detail the infection mechanisms of coronaviruses. These viruses are notorious for attacking the respiratory tract of humans and animals.

27 Feb 2016

Scientists reveal how the brain processes information with lightning speed

Surprisingly complex interactions between neurotransmitter receptors and other key proteins help explain the brain's ability to process information with lightning speed, according to a new study.

27 Feb 2016

Researchers find way to inhibit enzyme responsible for Alzheimer's disease

For decades, intensive research has been conducted on drugs all over the world to treat Alzheimer's patients. Although major progress has been made in diagnostics (the disease can be detected increasingly early and accurately), the therapeutic options remain limited.

27 Feb 2016

UEA research paves way for new wave of drugs to kill superbugs

Scientists at the University of East Anglia are getting closer to solving the problem of antibiotic resistance.

24 Feb 2016

Terumo CV Group introduces new addition to CAPIOX Oxygenator portfolio

Terumo Cardiovascular Group introduces the newest addition to the CAPIOX Oxygenator portfolio – the CAPIOX FX Advance Oxygenator. The CAPIOX FX Advance replaces the current CAPIOX FX15 and FX25 line of oxygenators manufactured in Elkton, Maryland.

17 Feb 2016

Membrane News and Research

New microfluidic biosensor can identify white blood cells quickly for AIDS diagnosis

Researchers uncover antitumoral nature of maslinic acid in colon cancer cells

CWRU researcher to customize tobacco mosaic virus to treat human cancers

New, regenerative medicine approach developed to remove congenital cataracts in infants

MGH researchers identify how Shigella injects proteins into target host cells

Novel nanoparticle technology can decipher protein structures and help access drug targets

Absence of PEMT enzyme leads to development of fatty liver disease and tumours in thin patients

Researchers uncover new pathway for mitochondrial cell death

Study provides critical insight into Warburg effect

Researchers reveal link between mitochondrial dysfunction and Fuchs' Endothelial Corneal Dystrophy

Researchers aim to develop gentler treatment that 'tricks' cancer cells

Study provides insights into cellular mechanisms that may contribute to new osteoarthritis treatments

Depression may be a systemic disease, say researchers

Added benefit of aflibercept not proven in myopic choroidal neovascularisation

Polyunsaturated lipids can alter binding rate of two receptors involved in Parkinson's and Alzheimer's

Cryo-electron microscopy helps analyze infection mechanisms of coronaviruses in detail

Scientists reveal how the brain processes information with lightning speed

Researchers find way to inhibit enzyme responsible for Alzheimer's disease

UEA research paves way for new wave of drugs to kill superbugs

Terumo CV Group introduces new addition to CAPIOX Oxygenator portfolio

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