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Secondary Speckle Sensing Microscopy may rapidly and accurately diagnose malaria

Correctly and quickly diagnosing malaria is essential for effective and life-saving treatment. But rapid detection, particularly in remote areas, is not always possible because current methods are time-consuming and require precise instrumentation and highly skilled microscopic analysis. Now, a promising new optical imaging system, described in a paper published today in the Optical Society's (OSA) open-access journal Biomedical Optics Express, may make the diagnosis of this deadly disease much easier, faster, and more accurate.

19 Apr 2012

First specific antidote for cocaine toxicity

Scientists at The Scripps Research Institute have shown that an injectable solution can protect mice from an otherwise lethal overdose of cocaine. The findings could lead to human clinical trials of a treatment designed to reverse the effects of cocaine in case of emergency. Cocaine is involved in more than 400,000 emergency-room visits and about 5,000 overdose deaths each year in the United States.

19 Apr 2012

GSK, Epizyme and Constellation to develop next generation of epigenetic drugs for cancer

Scientific insights that expand on the teachings of Mendel, Watson and Crick, and underpinnings of the Human Genome Project are moving drug companies along the path to development of new medicines based on deeper insights into how factors other than the genetic code influence health and disease. That's the topic of the cover story in the current edition of Chemical & Engineering News (C&EN), the weekly newsmagazine of the American Chemical Society (ACS), the world's largest scientific society.

19 Apr 2012

North American scientists to explore genetic markers for autism

A medical researcher at the University of Alberta is working with scientists from across North America to find out if there are genetic markers for autism. More than 15 scientists will examine DNA samples from children with autism and their infant siblings to see if the siblings are at high risk.

19 Apr 2012

Results from Presidio’s PPI-668 Phase 1a-1b trial on chronic HCV

Presidio Pharmaceuticals, Inc. announced results today from a Phase 1a-1b clinical trial of PPI-668, a potent, pan-genotypic HCV NS5A inhibitor being developed for the treatment of patients with chronic hepatitis C.

19 Apr 2012

Poll: 80% of American voters favor national school nutrition standards

Eighty percent of American voters favor national standards that would limit calories, fat, and sodium in snack and - la carte foods sold in U.S. schools and encourage the consumption of fruits, vegetables and low-fat dairy items, according to a new poll commissioned by the Kids' Safe & Healthful Foods Project, a joint project of The Pew Charitable Trusts and the Robert Wood Johnson Foundation.

19 Apr 2012

Positive results from CrystalGenomics’ CG100649 Phase 2b OA study

CrystalGenomics, Inc., a biopharmaceutical company headquartered in Korea, has just announced positive results from the Phase 2b osteoarthritis (OA) study of the CG100649, CrystalGenomics' next-generation NSAID candidate.

19 Apr 2012

New genetic signature may predict NSCLC patients at risk of relapse

A new genetic signature identified by Spanish researchers may provide doctors with robust and objective information about which patients with early stage lung cancer are at low or high risk of relapse following surgery, investigators report at the 3rd European Lung Cancer Conference in Geneva. Their work also opens new avenues for immunotherapy for lung cancer.

19 Apr 2012

Oral bacteria may cause problems in arthritis patients

The culprit behind a failed hip or knee replacements might be found in the mouth. DNA testing of bacteria from the fluid that lubricates hip and knee joints had bacteria with the same DNA as the plaque from patients with gum disease and in need of a joint replacement.

19 Apr 2012

CAM may have several positive effects on people with type 2 diabetes

A new joint study by Group Health Research Institute and Bastyr University Research Institute found that type 2 diabetes patients who received naturopathic care (as an adjunct to conventional care) had lower blood-sugar levels, better eating and exercise habits, improved moods, and a stronger sense of control over their condition than did patients receiving only conventional care.

19 Apr 2012

Study explains why some people develop kidney stones and others do not

Kidney stones strike an estimated 1 million Americans each year, and those who have experienced the excruciating pain say it is among the worst known to man (or woman).

19 Apr 2012

Bayer receives FDA clearance for new blood glucose monitoring system

Bayer HealthCare today announced that the U.S. Food and Drug Administration (FDA) has cleared its CONTOUR Next EZ, a new blood glucose monitoring (BGM) system for use in the United States.

19 Apr 2012

Blood test to diagnose depression in adolescents

Researchers have developed a blood test that can diagnose depression in teens, a step they hope will lead to a better way to identify the disorder in young people. At present diagnosing depression depends entirely on a patient's willingness to report symptoms. For teens, the diagnosis is particularly challenging, given the natural emotional ups and downs of adolescence.

18 Apr 2012

Testosterone may help heart failure patients: Study

The researchers used testosterone patches and injections that improved the breathing and exercise abilities of people with heart failure, a chronic inability of the heart to pump enough blood to the rest of the body. Although most of the study participants were men, the researchers said the results would likely apply to women as well, through much smaller doses of testosterone.

18 Apr 2012

New PBC tool for prioritizing laboratory-based CD-4 cell count testing

One of the major problems that has slowed progress toward universal access to life-saving antiretroviral therapy (ART) to treat AIDS in developing nations has been limited availability of laboratories and trained medical staff to conduct blood tests of immune system CD-4 T-cell levels that indicate when to start ART.

18 Apr 2012

Large study examines diagnostic yield of colonoscopy to investigate melena

A new study from researchers in Oregon reports that the diagnostic yield of colonoscopy to investigate melena after a nondiagnostic upper endoscopy is lower, 4.8 percent, than previously reported. The rate of therapeutic intervention in this population is very low; therefore, patients with melena and a nondiagnostic upper endoscopy who are stable and without evidence of ongoing bleeding may be able to safely undergo elective colonoscopy.

18 Apr 2012

Kaposi's sarcoma-associated herpesvirus senses and reacts to host cell's impending death

A research team led by Children's National Medical Center has identified a trigger that causes latent Kaposi's sarcoma-associated herpesvirus (KSHV) to rapidly replicate itself. KSHV causes Kaposi's sarcoma, primary effusion lymphoma, and other cancers that commonly affect immunocompromised patients, including those with AIDS.

18 Apr 2012

A guide to catch and treat hypertension early in children

High blood pressure in children and adolescents is a growing health problem that is often overlooked by physicians, according to a University of Michigan Health System article published in American Family Physician that offers doctors a guide to catching and treating hypertension early.

18 Apr 2012

Engineered particles tied to penetratin discover, deliver ligands for mitochondria, ribosomes

Scientists who developed a technology for identifying and targeting unique protein receptor ZIP Codes on the cellular surface have found a way to penetrate the outer membrane and deliver engineered particles - called iPhage - to organelles inside the cell.

18 Apr 2012

Study sheds light on why ageing makes us more susceptible to gum disease

New research from Queen Mary, University of London in collaboration with research groups in the USA sheds light on why gum disease can become more common with old age.

18 Apr 2012