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Researchers demonstrate that iPS stem cells may be used for gene therapy

This research, published on Oct. 12 on the Nature review website, provides evidence of a major concept could pave the way for the future use of these stem cells to treat humans, through perspective gene therapies.

14 Oct 2011

Scientists characterize and isolate potential stem cells to treat MS, myelin disorders

Scientists have improved upon their own previous world-best efforts to pluck out just the right stem cells to address the brain problem at the core of multiple sclerosis and a large number of rare, fatal children's diseases.

14 Oct 2011

ESCs express genes linked with early germ cell specification

Ordinarily, embryonic stem cells exist only a day or two as they begin the formation of the embryo itself. Then they are gone. In the laboratory dish, however, they act more like perpetual stem cells - renewing themselves and exhibiting the ability to form cells of almost any type, a status called totipotency.

14 Oct 2011

Study: Green vegetables boost immune function

Researchers reporting online in the journal Cell, a Cell Press publication, on October 13th have found another good reason to eat your green vegetables, although it may or may not win any arguments with kids at the dinner table.

14 Oct 2011

Nature publishes Sangamo's gene correction strategy for A1AT deficiency

Sangamo BioSciences, Inc. (Nasdaq: SGMO) announced the publication of a preclinical study demonstrating highly specific, functional correction of the alpha 1-antitrypsin (A1AT) gene defect in patient-derived induced pluripotent stem cells (iPSCs) using zinc finger nucleases.

14 Oct 2011

Survey analyses management of patients suffering from EGFRI toxicities

A recent survey of nurses from seven European countries, published in the peer-reviewed journal ecancermedicalscience, has analysed the management of patients suffering from toxicities due to treatment with epidermal growth factor receptor inhibitors.

14 Oct 2011

New dual drug combinations in development for various cancers

A rarely used—and as yet largely unproven—approach to drug development has emerged as a significant tool in the effort to create high-impact new cancer drugs.

14 Oct 2011

Merck announces results from ISENTRESS Phase III combination study on HIV-1

Merck, known as MSD outside the United States and Canada, today announced results of new exploratory pre-specified analyses from the ongoing STARTMRK Phase III study of its integrase inhibitor ISENTRESS (raltegravir) Tablets in combination therapy compared to efavirenz in combination therapy in previously untreated adult HIV-1-infected patients.

14 Oct 2011

BCL11A protein might serve as potential target for sickle cell disease

Flipping a single molecular switch can reverse illness in a model of sickle cell disease, according to a study by researchers at Children's Hospital Boston and Dana-Farber Cancer Institute. When turned off, the switch, a protein called BCL11A, allows the body to manufacture red blood cells with an alternate form of hemoglobin unaffected by the mutation that causes the disease.

14 Oct 2011

Scientisits uncover evidence of powerful new cancer genetic networks

In findings with major implications for the genetics of cancer and human health, researchers at Beth Israel Deaconess Medical Center (BIDMC) and two other science teams in New York City and Rome have uncovered evidence of powerful new genetic networks and showed how it may work to drive cancer and normal development.

14 Oct 2011

Manhattan Scientifics' nano-electromagnetic sensing technology can detect MRD in leukemia

Manhattan Scientifics announced today that the National Cancer Institute (NCI) has funded a grant for its Senior Scientific, LLC unit, for the use of its proprietary, highly precise magnetic cancer cell measurement in leukemia research for determining the progress of cancer treatment.

14 Oct 2011

New insight into how emphysema and COPD develop

By studying mice exposed to tobacco smoke for a period of months, researchers have new insight into how emphysema and chronic obstructive pulmonary disease (COPD) develop.

14 Oct 2011

Cord blood stem cells can repair cardiac muscle after heart attack

At least 20 million people survive heart attacks and strokes every year, according to World Health Organisation estimates, but many have poor life expectancy and require continual costly clinical care. The use of patient's own stem cells may repair heart attacks, although their benefit may be limited due to scarce availability and ageing. The researchers have found heart muscle-like cells grown using stem cells from human umbilical cord blood could help repair heart muscle cells damaged by a heart attack.

14 Oct 2011

Mathematical optimization models to improve radiation therapy for cancer

Engineering researchers at the University of Arkansas have developed mathematical optimization models that will make radiation treatment plans safer and more efficient than conventional plans.

From Elekta 14 Oct 2011

Insight into how powerful anti-HIV antibody grabs hold of the virus

Researchers at The Scripps Research Institute have uncovered the surprising details of how a powerful anti-HIV antibody grabs hold of the virus. The findings, published in Science Express on October 13, 2011, highlight a major vulnerability of HIV and suggest a new target for vaccine development.

14 Oct 2011

Potential new protein target for sickle cell disease

National Institutes of Health-funded scientists have corrected sickle cell disease in adult laboratory mice by activating production of a special blood component normally produced before, but not after, birth.

14 Oct 2011

Researchers control itch without dulling morphine's pain-killing effects

Itching is one of the most prevalent side effects of powerful, pain-killing drugs like morphine, oxycodone and other opioids. The opiate-associated itch is so common that even women who get epidurals for labor pain often complain of itching. For many years, scientists have scratched their own heads about why drugs that so effectively suppress pain also induce itch.

14 Oct 2011

Stopping necroptosis in keratinocytes prevents skin inflammation

The outer layer of the skin, called the epidermis, forms a critical physical and immunological wall that serves as the body's first line of defense against potentially harmful microorganisms. Most of the epidermis consists of cells called keratinocytes that build a mechanical barrier but also perform immune functions.

14 Oct 2011

Study: miR-34b gene associated with aggressive form of melanoma

A certain microRNA gene, miR-34b, could be a useful biomarker in early diagnosis of the most lethal forms of melanoma, according to new research published by KGI Professor Animesh Ray and his research collaborators.

14 Oct 2011

Limited decision-making ability of individual cells is bolstered in masses

Researchers from Johns Hopkins have quantified the number of possible decisions that an individual cell can make after receiving a cue from its environment, and surprisingly, it's only two.

14 Oct 2011