Immunodeficiency News and Research

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Immunodeficiency (or immune deficiency) is a state in which the immune system's ability to fight infectious disease is compromised or entirely absent.

SARS-CoV-2 ORF8 protein binds to dendritic cells and induces a hyper-inflammatory cytokine storm

In a recent study posted to the bioRxiv* pre-print server, researchers examined how the interaction of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) open reading frame 8 (ORF8) protein with host dendritic cells (DCs) induced cytokine storm.

8 Jun 2022

Monkeypox virus transmission via sexual contact

A new study discusses the transmission of monkeypox through sexual contact.

6 Jun 2022

Details of SARS-CoV-2 seroprevalence surveys supported by the US CDC

Researchers reviewed and analyzed data from SARS-CoV-2 serosurveys supported by the United States Centers for Disease Prevention and Control in the low- and middle-income countries.

6 Jun 2022

Trial of peptide-centered SARS-CoV-2 T-cell activator in B-cell deficient individuals

A recent phase 1/2 study under review at the Nature Portfolio journal and posted to the Research Square* preprint server demonstrated that a peptide-centered severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) T-cell activator, CoVac-1, was efficient in B-cell deficient people.

6 Jun 2022

Common experiences of stigma in people living with Long Covid

The vast majority of individuals, both with and without a long COVID diagnosis, have experienced some form of stigma.

1 Jun 2022

HIV research enables knowledge transfer for improved COVID-19 response

Global virology and immunology networks that were originally developed for HIV vaccine research were rapidly adapted to study COVID-19.

31 May 2022

Sarbecovirus open reading frame 7a suppresses major histocompatibility complex-I antigen presentation

Researchers demonstrated the sarbecovirus open reading frame 7a (ORF7a)-induced hindrance of the antigen presentation by the major histocompatibility complex class I (MHC-I) in hosts.

30 May 2022

Mapping the Types and Traits of Immune Cells

In this interview, News-Medical speaks to two researchers each discussing their respective studies that have contributed to the Human Cell Atlas; Dr. Chenqu Suo and Dr. Cecilia Domínguez Conde from the Wellcome Sanger Institute.

30 May 2022

A polymer-nanoparticle hydrogel to subcutaneously deliver broadly neutralizing antibodies against SARS-CoV-2

Researchers compared the polymer-nanoparticle hydrogel system and standard routes of delivery of broadly neutralizing antibodies against SARS-CoV-2 in a mouse model.

27 May 2022

After SARS-CoV-2 infection, anti-chemokine antibodies correlate with better outcomes

A recent study posted to the bioRxiv* preprint server illustrated that specific chemokine antibodies aid in recognizing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) convalescent individuals with a desirable disease course.

26 May 2022

The effectiveness of sotrovimab vs. molnupiravir in preventing severe COVID-19 outcomes in non-hospitalized high-risk COVID-19 adult patients

Researchers compared the efficacy of sotrovimab and molnupiravir in preventing severe COVID-19 outcomes among non-hospitalized and high-risk COVID-19 patients across England.

25 May 2022

Hamster contact exposure challenge model assesses protection conferred by SARS-CoV-2 vaccination or prior infection against reinfection

Researchers assessed the neutralization efficacy of a saRNA vaccine targeting SARS-CoV-2 S protein against reinfection among hamsters with prior vaccination or infection.

24 May 2022

Novel genetic test enables earlier, more accurate diagnosis of primary immunodeficiency disorders

Primary immunodeficiency disorders (PID) can result in chronic and sometimes life-threatening infections. More than 450 PIDs have been described, but timely and accurate diagnoses remain a challenge.

23 May 2022

Study suggests that recall of B cell memory may depend on relative locations of prime and boost immunization

A new study investigated whether a specific population of local Bmem cells in the proximal LNs produce secondary GC responses that are different from those at distal sites and if the location in humoral immunity is relevant only to nonlymphoid tissues.

23 May 2022

Immunodeficiency News and Research

Further Reading

SARS-CoV-2 ORF8 protein binds to dendritic cells and induces a hyper-inflammatory cytokine storm

Monkeypox virus transmission via sexual contact

Details of SARS-CoV-2 seroprevalence surveys supported by the US CDC

Trial of peptide-centered SARS-CoV-2 T-cell activator in B-cell deficient individuals

Common experiences of stigma in people living with Long Covid

HIV research enables knowledge transfer for improved COVID-19 response

Sarbecovirus open reading frame 7a suppresses major histocompatibility complex-I antigen presentation

Mapping the Types and Traits of Immune Cells

A polymer-nanoparticle hydrogel to subcutaneously deliver broadly neutralizing antibodies against SARS-CoV-2

After SARS-CoV-2 infection, anti-chemokine antibodies correlate with better outcomes

The effectiveness of sotrovimab vs. molnupiravir in preventing severe COVID-19 outcomes in non-hospitalized high-risk COVID-19 adult patients

Hamster contact exposure challenge model assesses protection conferred by SARS-CoV-2 vaccination or prior infection against reinfection

Novel genetic test enables earlier, more accurate diagnosis of primary immunodeficiency disorders

Study suggests that recall of B cell memory may depend on relative locations of prime and boost immunization

Investigation of long-COVID in children with immunodeficiency

Real-world vaccine effectiveness of mRNA-1273 and BNT1262b2 in immunocompromised adults

Exploring cross-neutralizing anti-SARS-CoV-2 antibody responses among the general population

New study reveals the genetic mechanism behind severe staphylococcal infections

Combined COVID-19 vaccination regimen found to induce more potent anti-SARS-CoV-2 antibodies

Case report: human breast milk from vaccinated woman clears persistent SARS-CoV-2 infection

Event guide: 4th Extra-Hepatic Lipid-Based Nanoparticles Delivery Summit eBook

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

The impact of vibration on microscopy

How Omics Technologies Are Transforming Biological Research and Drug Discovery

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