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Hyperinflammation triggers long COVID headaches

Researchers characterize the immunological and metabolic alterations involved in chronic headache onset during post-acute sequelae of COVID-19.

13 Mar 2023

How does temperature affect host responses to SARS-CoV-2 and IAV infection in human nasal epithelial cells?

A new preprint examines the response to these pathogens in the nose, which is the primary portal of entry for both.

13 Mar 2023

SARS-CoV-2 replication persists for weeks in lungs after symptom onset in severe COVID-19

Researchers observe persistent SARS-CoV-2 replication in severe COVID-19 patient lungs.

13 Mar 2023

Important backup mechanism of human immune cells elucidated

The enzyme TBK1 is an important component of the innate immune system that plays a critical role in the defense against viruses.

10 Mar 2023

Investigating the impact of COVID-19 vaccinations in immunocompromised adult patients

In a recent study posted to the medRxiv* preprint server, researchers assessed the impact of third and fourth coronavirus disease 2019 (COVID-19) vaccination doses on immunity against COVID-19 among immunocompromised adult patients.

9 Mar 2023

Individuals with autosomal and X-linked recessive deficiency of IRAK-4 and MyD88 are more susceptible to developing hypoxemic COVID-19 pneumonia

Researchers identified that individuals with a deficiency of myeloid differentiation primary response 88 (MyD88) and interleukin-1 receptor-associated kinase 4 (IRAK-4) due to an autosomal recessive condition were highly susceptible to developing hypoxemic coronavirus disease 2019 (COVID-19) pneumonia when infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

9 Mar 2023

Nasal administration of a fully human anti-CD3 monoclonal antibody modulates T cell inflammatory responses in COVID-19

Researchers assessed the impact of an anti-CD3 monoclonal antibody called Foralumab in COVID-19 treatment.

9 Mar 2023

C-reactive protein has a beneficial function in systemic lupus erythematosus

The biological function of the C-reactive protein, CRP, has long been unknown. Researchers at Linköping University in Sweden now show that this protein has a beneficial function in systemic lupus erythematosus, SLE, an inflammatory disease.

9 Mar 2023

Connection between mitochondrial metabolite and activation of inflammatory response revealed

A new study shows for the first time a connection between a mitochondrial metabolite and the activation of an inflammatory response.

8 Mar 2023

Interferon autoantibodies not implicated in long-COVID

Researchers assess the proportion of interferon autoantibodies in long COVID patients.

6 Mar 2023

Naked mRNA delivered using needle-free PYRO injection presents a safe and effective potential vaccination method

Researchers examined the vaccination effects and local antigen expression efficiency of a needle-free vaccination technique involving pyro-drive liquid jet injection (PYRO) to deliver the naked messenger ribonucleic acid (mRNA) to the skin.

3 Mar 2023

Multi-organ scRNA-seq reveals targeting pro- or anti-inflammatory regulators may be exploited for personalized treatment of immune diseases

Researchers performed multi-organ single-cell RNA sequencing of collagen-induced arthritis murine model to evaluate immune-mediated inflammatory disease alterations by characterizing the genome, organizing the organome, and prioritizing pathways in the multi-organ data.

3 Mar 2023

Study identifies renalase as a novel independent predictor of COVID-19-related mortality

Researchers assessed the role of renalase as an independent predictor of COVID-19-related mortality.

2 Mar 2023

What is the role of B cells in breast cancer pathology?

In a recent study published in Cancers, researchers comprehensively summarized all available information about B cells in the context of breast cancer.

1 Mar 2023

An overview of the anti-inflammatory effects of nuts

Researchers summarize existing literature on the effects of consuming nuts on biomarkers of inflammation and oxidative stress.

28 Feb 2023

Clec9A-RBD immunization could trigger robust and sustained systemic and mucosal immune responses against rapidly evolving SARS-CoV-2 variants

Researchers assessed the impact of a single-dose dendritic cell vaccine candidate on immune responses against SARS-CoV-2.

23 Feb 2023

RBD-NTD-subunit protein vaccine provides a promising booster vaccination strategy capable of protecting against known SARS-CoV-2 variants

Researchers assessed the impact of SARS-CoV-2 spike NTD incorporation into the RBD protein vaccine.

22 Feb 2023

Dietary polyphenols may play a role in regulating inflammatory immune responses

PCB2DG, a polyphenol with anti-inflammatory properties, works by targeting and directly interacting with the major glutamine transporter protein, alanine serine cysteine transporter 2 (ASCT2), to inhibit the uptake of glutamine, an important amino acid found in the blood.

22 Feb 2023

Researchers report the circulation of a novel MERS-like coronavirus in Malayan pangolins

Researchers reported the circulation of a novel MERS-like coronavirus among Malayan pangolins, Manis javanica HKU4-associated CoV (MjHKU4r-CoV).

21 Feb 2023

Study indicates that macrophages that reside in the lymph nodes contribute to the initial Zika virus spread

Researchers mapped Zika virus infections in the lymph nodes to determine how the Zika virus enters from different points in the skin and disseminates through the body.

20 Feb 2023

Interferon News and Research

Hyperinflammation triggers long COVID headaches

How does temperature affect host responses to SARS-CoV-2 and IAV infection in human nasal epithelial cells?

SARS-CoV-2 replication persists for weeks in lungs after symptom onset in severe COVID-19

Important backup mechanism of human immune cells elucidated

Investigating the impact of COVID-19 vaccinations in immunocompromised adult patients

Individuals with autosomal and X-linked recessive deficiency of IRAK-4 and MyD88 are more susceptible to developing hypoxemic COVID-19 pneumonia

Nasal administration of a fully human anti-CD3 monoclonal antibody modulates T cell inflammatory responses in COVID-19

C-reactive protein has a beneficial function in systemic lupus erythematosus

Connection between mitochondrial metabolite and activation of inflammatory response revealed

Interferon autoantibodies not implicated in long-COVID

Naked mRNA delivered using needle-free PYRO injection presents a safe and effective potential vaccination method

Multi-organ scRNA-seq reveals targeting pro- or anti-inflammatory regulators may be exploited for personalized treatment of immune diseases

Study identifies renalase as a novel independent predictor of COVID-19-related mortality

What is the role of B cells in breast cancer pathology?

An overview of the anti-inflammatory effects of nuts

Clec9A-RBD immunization could trigger robust and sustained systemic and mucosal immune responses against rapidly evolving SARS-CoV-2 variants

RBD-NTD-subunit protein vaccine provides a promising booster vaccination strategy capable of protecting against known SARS-CoV-2 variants

Dietary polyphenols may play a role in regulating inflammatory immune responses

Researchers report the circulation of a novel MERS-like coronavirus in Malayan pangolins

Study indicates that macrophages that reside in the lymph nodes contribute to the initial Zika virus spread

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