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New UK-derived SARS-CoV-2 variant does not affect neutralizing antibodies efficiency, study says

A team of scientists conducted structural analysis of a newly emerged UK variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). They present evidence that suggests that while the new variant has increased infectivity it is not resistant to neutralizing antibodies.

13 Jan 2021

New technology could protect against different coronavirus variants

The SARS-CoV-2 virus that is causing the COVID-19 pandemic is just one of many different viruses in the coronavirus family.

13 Jan 2021

SARS-CoV-2 may join the ranks of mild cold-causing coronaviruses

What is the endgame for SARS-CoV-2, the virus that is causing worldwide devastation? If it becomes endemic -- circulating in the general population -- and most people are exposed in childhood, SARS-CoV-2 may join the ranks of mild cold-causing coronaviruses that currently circulate in humans, according to a model developed by Emory and Penn State scientists.

13 Jan 2021

Lactating women should discuss risks and benefits of COVID-19 vaccination, says ABM

The Academy of Breastfeeding Medicine (ABM) does not recommend cessation of breastfeeding for individuals who are vaccinated against COVID-19.

13 Jan 2021

Researchers develop novel antibody fragments against SARS coronavirus-2

An international research team led by the University of Bonn (Germany) has identified and further developed novel antibody fragments against the SARS coronavirus-2. These "nanobodies" are much smaller than the classic antibodies used to treat US President Donald Trump, for example.

13 Jan 2021

New publication describes DiosCURE’s multivalent single-chain antibodies to inactivate SARS-CoV-2

DiosCURE SE announced a publication in Science describing its core technology of multivalent single-chain antibodies with a unique molecular mode-of-action to inactivate SARS-CoV-2 virions. An international team led by scientists at the University of Bonn developed and characterized the lead candidates, which are exclusively licensed by DiosCURE.

13 Jan 2021

Biologists reveal unusual structure of coronavirus protein linked to immune evasion

A team of HIV researchers, cellular biologists, and biophysicists who banded together to support COVID-19 science determined the atomic structure of a coronavirus protein thought to help the pathogen evade and dampen response from human immune cells.

13 Jan 2021

Antibody-Fc-mediated innate immunity shapes COVID-19 severity

A short paper that appeared recently on the preprint bioRxiv server pointed to a link between specific characteristics of anti-SARS-CoV-2 antibodies associated with the severity of COVID-19.

12 Jan 2021

Intranasal vaccination effectively reduces viral shedding of SARS-CoV-2 in monkeys

A new preprint that appeared on the bioRxiv server reports that intranasal vaccination with the D614G variant of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in rhesus monkeys reduces viral shedding. This is an experiment in non-human primates (NHP), and its extrapolation to humans is unclear as yet.

12 Jan 2021

Structure of SARS-CoV-2 cytoplasmic tail uncovered

The virus's cytosolic tail also interacts with the host cell to promote its entry into the endoplasmic reticulum (ER). A new study appearing on the bioRxiv preprint server elucidates the conformation of this region of the virus, which will help understand how its form is related to its function in viral entry.

12 Jan 2021

Effect of mutations in the South African SARS-CoV-2 variant on transmission and neutralization

One such strain is the South African 501.V2 and UK B1.1.7 strains, which have been isolated from many countries and seem to spread faster than the ancestral strain. A preprint that recently appeared on the bioRxiv server reports the computational structure of this strain and the possible effect of the mutations on infectivity and neutralization.

12 Jan 2021

Researchers discover a new approach to inhibit intrahepatic cholangiocarcinoma

Reprogramming the rich connective tissue microenvironment of a liver cancer known as intrahepatic cholangiocarcinoma (ICC) inhibits its progression and resistance to standard chemotherapy in animal models, researchers from Massachusetts General Hospital have found.

12 Jan 2021

Antigenic "supersite" could improve design of COVID-19 vaccines

Researchers in the United States have defined an antigenic “supersite” within the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that could have important implications for the design of vaccines to protect against coronavirus disease 2019 (COVID-19).

12 Jan 2021

Nanobodies have potential to be developed into a treatment for COVID-19

Researchers at Karolinska Institutet in Sweden have developed, in collaboration with researchers in Germany and the U.S., new small antibodies, also known as nanobodies, which prevent the SARS-CoV-2 coronavirus from entering human cells.

12 Jan 2021

OXGENE introduces SLIM platform for discovery of antibodies against membrane proteins

OXGENE™ announces the introduction of its self-labelling integral membrane (SLIM™) protein discovery system.

12 Jan 2021

Researchers determine the atomic structure of protein that helps coronavirus to evade immune cells

12 Jan 2021

Discovery of SARS-CoV-2 neutralizing antibodies from a naïve human Ab library

Now, a new preprint research paper published on the bioRxiv server shows how closely the antibodies formed in exposed humans resemble the germline antibody molecules. This could lead to the development of novel therapeutics to counter the pandemic.

12 Jan 2021

SARS-CoV-2 exposure in England could be double reported seroprevalence

A new study that recently appeared on the preprint server medRxiv* makes use of a combined method to estimate population exposure to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), taking into account the fact that patients who recover from the infection often do not have circulating antibodies against the virus.

11 Jan 2021

The mystery of Giglio island’s resistance to COVID-19

An intriguing new study explores the mechanisms by which an Italian island called Giglio remained resistant to coronavirus disease 2019 (COVID-19) even after much exposure.

11 Jan 2021

Study supports continuing phase 3 trials of Ad26.COV2.S SARS-CoV-2 vaccine

An international team of researchers has provided further evidence to confirm the immunogenicity and efficacy of a recombinant adenovirus vaccine currently being tested in phase 3 trials for its ability to protect against infection with severe acute respiratory coronavirus 2 (SARS-CoV-2) – the agent that causes coronavirus disease 2019 (COVID-19).

11 Jan 2021

Antibodies News and Research

New UK-derived SARS-CoV-2 variant does not affect neutralizing antibodies efficiency, study says

New technology could protect against different coronavirus variants

SARS-CoV-2 may join the ranks of mild cold-causing coronaviruses

Lactating women should discuss risks and benefits of COVID-19 vaccination, says ABM

Researchers develop novel antibody fragments against SARS coronavirus-2

New publication describes DiosCURE’s multivalent single-chain antibodies to inactivate SARS-CoV-2

Biologists reveal unusual structure of coronavirus protein linked to immune evasion

Antibody-Fc-mediated innate immunity shapes COVID-19 severity

Intranasal vaccination effectively reduces viral shedding of SARS-CoV-2 in monkeys

Structure of SARS-CoV-2 cytoplasmic tail uncovered

Effect of mutations in the South African SARS-CoV-2 variant on transmission and neutralization

Researchers discover a new approach to inhibit intrahepatic cholangiocarcinoma

Antigenic "supersite" could improve design of COVID-19 vaccines

Nanobodies have potential to be developed into a treatment for COVID-19

OXGENE introduces SLIM platform for discovery of antibodies against membrane proteins

Researchers determine the atomic structure of protein that helps coronavirus to evade immune cells

Discovery of SARS-CoV-2 neutralizing antibodies from a naïve human Ab library

SARS-CoV-2 exposure in England could be double reported seroprevalence

The mystery of Giglio island’s resistance to COVID-19

Study supports continuing phase 3 trials of Ad26.COV2.S SARS-CoV-2 vaccine

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