B Cell News and Research

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NO could improve recovery of critically ill patients in intensive care

The latest results from an expedition to Mount Everest that looked at the body's response to low oxygen levels suggest that drugs or procedures that promote the body's production of a chemical compound called nitric oxide (NO) could improve the recovery of critically ill patients in intensive care.

7 Oct 2011

Neutrophils inhibit restenosis in patients with atherosclerosis after stent implantation

A research team led by LMU's Professor Christian Weber has now shown that a specific cell type called neutrophils, and molecules that they secrete, inhibit this life-threatening complication - which is observed in up to one-third of all stent implantations.

7 Oct 2011

Hysterectomy increases brain iron levels in both men and women

The human body has a love-hate relationship with iron. Just the right amount is needed for proper cell function, yet too much is associated with brain diseases like Alzheimer's and Parkinson's.

7 Oct 2011

Scientists discover how cells detect tissue damage and modify their repair properties

Scientists have discovered how cells detect tissue damage and modify their repair properties accordingly. The findings, published in the journal Developmental Cell, could open up new opportunities for improving tissue repair in patients following illness or surgery.

7 Oct 2011

Virginia Bioinformatics Institute releases upgraded ENISI software

Researchers with the Virginia Bioinformatics Institute at Virginia Tech have released an upgrade to the institute's ENteric Immunity SImulator (ENISI) software, which models immune responses to beneficial and harmful bacteria that enter the gastrointestinal tract of mice, pigs, and humans.

7 Oct 2011

Study shows Sox2 expression in many adult stem cells

Investigators at the Massachusetts General Hospital (MGH) Center for Regenerative Medicine and the Harvard Stem Cell Institute (HSCI) have found that Sox2 - one of the transcription factors used in the conversion of adult stem cells into induced pluripotent stem cells (iPSCs) - is expressed in many adult tissues where it had not been previously observed.

7 Oct 2011

Thriving stem cells created by cloning technique

In a breakthrough that has been debated and awaited for long, scientists have finally derived colonies of embryonic stem cells from human embryos created using cloning technology.

6 Oct 2011

X-BODY, TRL enter collaboration to identify therapeutic target epitopes

X-BODY, Inc., a developer of monoclonal antibody therapeutics, today announced a partnership with Tanabe Research Laboratories U.S.A., Inc. (TRL). The companies will collaborate to identify therapeutic target epitopes and develop monospecific and/or bispecific antibodies to the identified therapeutic targets.

4 Oct 2011

Virus DNA uncoated with aid of host cell

They have been around since the dawn of time and are a model of evolutionary success: viruses. Viruses are extremely adaptable but they have a problem: They cannot reproduce, so they smuggle their genes into suitable host cells. In the case of some viruses, the viral DNA has to enter the cell nucleus to reproduce. This has been known for almost 50 years.

4 Oct 2011

Researchers gain insight on how roundworm's brain operates as it moves

Using new optical equipment, a team of 11 researchers put roundworms into a world of virtual reality, monitored both their behavior and brain activity and gained unexpected information on how the organism's brain operates as it moves.

4 Oct 2011

CRT, Cancer Research UK establish group of scientists with expertise in lipid metabolism

Cancer Research Technology, Cancer Research UK's commercial arm, has established a group of scientists with expertise in lipid metabolism - getting energy from fats and making building blocks for cell growth - to develop targets for potential new cancer drugs.

4 Oct 2011

Clinical study: Higher radiation dose does not improve overall survival for NSCLC

A higher dose of radiation (74 Gy) does not improve overall survival for non-small cell lung cancer that has spread to the lymph nodes, compared to the standard radiation dose (60 Gy), according to an interim analysis of a late-breaking randomized study presented at the plenary session, October 3, 2011, at the 53rdAnnual Meeting of the American Society for Radiation Oncology.

4 Oct 2011

Lipomannan on TB bacterium's outer cell surface can block TNF production

The bacterium that causes tuberculosis has a unique molecule on its outer cell surface that blocks a key part of the body's defense. New research suggests this represents a novel mechanism in the microbe's evolving efforts to remain hidden from the human immune system.

4 Oct 2011

Researchers discover cell differentiation mechanism

Researchers from the Haematopoietic Differentiation and Stem Cell Biology group at the Centre for Genomic Regulation (CRG), have described one of the mechanisms by which a cell (from the skin, for example) can be converted into another which is completely different.

4 Oct 2011

Three Penn labs receive NIH grant to speed translation of medical research into patient care

Three labs from the University of Pennsylvania have received $12.5 million from the National Institutes of Health (NIH) as part of its $143.8 million national grant program to challenge the scientific status quo with innovative ideas that have the potential to speed the translation of medical research into improved health for the American public.

4 Oct 2011

Lung immune cells orchestrate the body's repair response following flu infection

There's more than one way to mop up after a flu infection. Now, researchers from the Perelman School of Medicine at the University of Pennsylvania report in Nature Immunology that a previously unrecognized population of lung immune cells orchestrate the body's repair response following flu infection.

4 Oct 2011

Virtual 18F-FDG PET/CT bronchoscopy may accurately detect NSCLC metastases

For patients with non-small cell lung cancer (NSCLC) the accurate determination of the lymph node status before therapy is critical to develop an individualized treatment plan. Research from the October issue of the Journal of Nuclear Medicine highlights a new way for this information to be collected -- a virtual fly-through three-dimensional 18F-FDG PET/computed tomography (FDG-PET/CT) bronchoscopy that has high diagnostic accuracy for the detection of regional lymph node metastases.

4 Oct 2011

UCLA neuro-physicists discover optimal brain rhythm for changing synaptic strength

The brain learns through changes in the strength of its synapses -- the connections between neurons -- in response to stimuli. Now, in a discovery that challenges conventional wisdom on the brain mechanisms of learning, UCLA neuro-physicists have found there is an optimal brain "rhythm," or frequency, for changing synaptic strength. And further, like stations on a radio dial, each synapse is tuned to a different optimal frequency for learning.

4 Oct 2011

Microscopy with helium ions may greatly enhance both surface and sub-cellular imaging

The ability to obtain an accurate three-dimensional image of an intact cell is critical for unraveling the mysteries of cellular structure and function. However, for many years, tiny structures buried deep inside cells have been practically invisible to scientists due to a lack of microscopic techniques that achieve adequate resolution at the cell surface and through the entire depth of the cell.

4 Oct 2011

CSHL publishes 'The Mammary Gland as an Experimental Model' book

Studies of mammary gland biology are essential in the fight against breast cancer. Moreover, the mammary gland represents an excellent model system for investigation of physiological and pathological processes that occur throughout the body.

4 Oct 2011

B Cell News and Research

NO could improve recovery of critically ill patients in intensive care

Neutrophils inhibit restenosis in patients with atherosclerosis after stent implantation

Hysterectomy increases brain iron levels in both men and women

Scientists discover how cells detect tissue damage and modify their repair properties

Virginia Bioinformatics Institute releases upgraded ENISI software

Study shows Sox2 expression in many adult stem cells

Thriving stem cells created by cloning technique

X-BODY, TRL enter collaboration to identify therapeutic target epitopes

Virus DNA uncoated with aid of host cell

Researchers gain insight on how roundworm's brain operates as it moves

CRT, Cancer Research UK establish group of scientists with expertise in lipid metabolism

Clinical study: Higher radiation dose does not improve overall survival for NSCLC

Lipomannan on TB bacterium's outer cell surface can block TNF production

Researchers discover cell differentiation mechanism

Three Penn labs receive NIH grant to speed translation of medical research into patient care

Lung immune cells orchestrate the body's repair response following flu infection

Virtual 18F-FDG PET/CT bronchoscopy may accurately detect NSCLC metastases

UCLA neuro-physicists discover optimal brain rhythm for changing synaptic strength

Microscopy with helium ions may greatly enhance both surface and sub-cellular imaging

CSHL publishes 'The Mammary Gland as an Experimental Model' book

Using single B cell screening to boost antibody discovery eBook

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

Advancing Intracellular Delivery with LumiPore®

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