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Fat-rich 'western diet' fuels cardiovascular disease, type 2 diabetes and obesity

A major risk factor for cardiovascular disease, type 2 diabetes and other health- and life-threatening conditions, obesity is epidemic in the United States and other developed nations where it's fueled in large part by excessive consumption of a fat-rich "Western diet."

30 Sep 2011

Free radical peroyxnitrite linked to failure of cytotoxic T-cells to eliminate tumors

Researchers at the Moffitt Cancer Center in Tampa, Fla., and colleagues have found that tumor cell resistance to a specific cancer immunotherapy designed to kill cancer cells can be blamed on a mechanism that involves the production of a free radical peroxynitrite (PNT) that causes resistance to therapeutic cancer-killing cells.

30 Sep 2011

Estradiol plays an important role in several metabolic diseases

Hormone researchers at the University of Houston (UH) have their sights set on providing long-term treatment options for diabetes, obesity and cardiovascular diseases by better understanding estradiol, the most potent naturally occurring estrogen.

30 Sep 2011

UCLA scientists create mouse model for autism

UCLA scientists have created a mouse model for autism that opens a window into the biological mechanisms that underlie the disease and offers a promising way to test new treatment approaches.

30 Sep 2011

ALK gene discovered by St. Jude scientists associated with FDA approved adult cancer drug

A drug recently approved by the U.S. Food and Drug Administration for treatment of an adult cancer targets a malfunctioning gene discovered more than a decade earlier at St. Jude Children's Research Hospital. The story highlights how scientific findings from St. Jude can be translated into therapies and tests that in addition to helping children, also help adults.

30 Sep 2011

Kimmel Cancer Center at Jefferson celebrates two decades of caring and collaboration to beat cancer

From October forward, the Kimmel Cancer Center at Jefferson (KCC), a National Cancer Institute-designated cancer center, is celebrating 20 years of service to the community and the groundbreaking cancer research from the scientists and physicians who've provided an invaluable contribution to medical science and healthcare.

30 Sep 2011

Researchers develop HTGTS to map translocatome in the genome

Researchers at Children's Hospital Boston and the Immune Disease Institute (IDI) have created a method for mapping "hot spots" in the genome where chromosomes are most likely to break and recombine, knowledge that helps define the rules that govern when and where breaks occur.

30 Sep 2011

Galectin posts new corporate video on galectin-inhibiting therapeutics to treat fibrosis and cancer

Galectin Therapeutics Inc. today announced that it posted a new corporate presentation video to its website, www.galectintherapeutics.com, that highlights the Company's leadership position in developing galectin-inhibiting therapeutics to treat fibrosis and cancer.

30 Sep 2011

Researchers discover 'superfast' muscles in mammals for the first time

As nocturnal animals, bats rely echolocation to navigate and hunt prey. By bouncing sound waves off objects, including the bugs that are their main diet, bats can produce an accurate representation of their environment in total darkness. Now, researchers at the University of Southern Denmark and the University of Pennsylvania have shown that this amazing ability is enabled by a physical trait never before seen in mammals: so-called "superfast" muscles.

30 Sep 2011

Three Georgia Tech projects to receive NSF's EFRI grants

The National Science Foundation (NSF) has awarded $6 million to fund three projects involving researchers from the Georgia Institute of Technology. Each four-year, $2 million grant was awarded through the NSF's Division of Emerging Frontiers in Research and Innovation.

30 Sep 2011

Patients with chronic hepatitis C less likely to take medications over time

Patients being treated for chronic hepatitis C become less likely to take their medications over time, according to a new study from the Perelman School of Medicine at the University of Pennsylvania.

30 Sep 2011

Immunotherapeutics for treatment of metastatic melanoma

A new cancer research program at Loyola University Chicago Stritch School of Medicine will develop therapies designed to turn patients' own immune systems into potent weapons against cancer.

30 Sep 2011

Researchers determine structure of RIG-I protein linked with viral infections

Researchers at Rutgers and UMDNJ-Robert Wood Johnson Medical School have determined the structure of a protein that is the first line of defense in fighting viral infections including influenza, hepatitis C, West Nile, rabies, and measles.

30 Sep 2011

Array announces results from selumetinib Phase 2 combination study on KRAS-mutant NSCLC

Array BioPharma Inc. today announced results from a randomized Phase 2 placebo-controlled study conducted by AstraZeneca comparing the efficacy of selumetinib in combination with docetaxel with docetaxel alone in the second-line treatment of 87 patients prospectively selected with KRAS-mutant, locally advanced or metastatic non-small cell lung cancer.

30 Sep 2011

Two UTA scientists win 2011 PECASE award for innovative research

Two scientists from The University of Texas at Austin are among the 2011 recipients of Presidential Early Career Awards for Scientists and Engineers (PECASE), the highest honor bestowed by the United States government on science and engineering professionals in the early stages of their independent research careers.

30 Sep 2011

Homobrassinolide may increase appetite, muscle mass and physical performance

New research in The FASEB Journal suggests that rats fed homobrassinolide, found in the mustard plant, produced an anabolic effect, and increased appetite and muscle mass, as well as the number and size of muscle fibers.

30 Sep 2011

Jails are holding increasing numbers of mentally ill

The Atlanta Journal-Constitution reports that in Georgia more mentally ill people are locked away than are treated in state psychiatric hospitals. In other state news about mental health, Florida seeks to recoup $4 million from company that managed Medicaid mental health services, and Milwaukee considers bolstering services.

30 Sep 2011

GWAS uncovers new genes associated with type 1 diabetes

The largest-ever analysis of genetic data related to type 1 diabetes has uncovered new genes associated with the common metabolic disease, which affects 200 million people worldwide. The findings add to knowledge of gene networks involved in the origin of this complex disorder, in which patients depend on frequent insulin injections to control their blood sugar levels.

30 Sep 2011

New technique helps identify how RNA molecules control gene expression

A new technique developed by researchers at the Stanford University School of Medicine allows researchers to identify the exact DNA sequences and locations bound by regulatory RNAs. This information is necessary to understand how the recently identified RNA molecules control the expression of neighboring and distant genes.

30 Sep 2011

PTK6 protein may play a different role in colon and breast cancer

A protein that regulates cell differentiation in normal tissue may play a different role in colon and breast cancer, activating proliferation of damaged cells, according to researchers at the University of Illinois at Chicago College of Medicine.

30 Sep 2011