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New use for a cell toxin found to inhibit survival proteins in cancer cells

A chemically-modified version of a mitochondrial toxin long used to control species of invasive fish in lakes has been found to selectively inhibit two "survival proteins" in cancer cells.

11 Jul 2007

No benefit from HRT for older women

New evidence confirms that hormone replacement therapy (HRT) should not be prescribed to older women who are many years past the menopause. The treatment will not help prevent chronic conditions such as heart disease in these women.

11 Jul 2007

Baxter presents findings from the ADAPT study

Baxter Healthcare Corporation has announced the presentation of findings from the ADAPT (Analysis of Data from ADVATE Prospective Trials) study program database showing a statistically significant relationship between the duration of time spent with factor VIII blood levels below one international unit per deciliter (1 IU/dL, one percent of normal factor VIII level) and an increase in the annual bleed rate in people with hemophilia A.

11 Jul 2007

Genetically engineered herpes simplex virus keeps arteries free-flowing

A genetically engineered herpes simplex virus, primarily known for causing cold sores, may help keep arteries "free-flowing" in the weeks following angioplasty or stent placement for patients, according to research published early in the online edition of PNAS (Proceedings of the National Academy of Sciences of the United States of America).

11 Jul 2007

Kaposi sarcoma tumors arise independently from multiple cells

Kaposi sarcoma is unique among cancers because most tumors grow from a small number of different cells, whereas nearly all other cancers arise from a single cell, according to a study published online July 10 in the Journal of the National Cancer Institute.

11 Jul 2007

Myomo receives FDA approval to market e100 NeuroRobotic System

Myomo, Inc. has announced that the company received U.S. Food and Drug Administration (FDA) 510(k) clearance to market the Myomo e100 NeuroRobotic System. Myomo's first product is a wearable, portable therapeutic modality designed to allow patients to self initiate and control movement of partially paralyzed limbs using their own biological signals.

11 Jul 2007

Court rules in favor of Massachusetts Eye and Ear Infirmary

The Massachusetts Eye and Ear Infirmary (MEEI) has announced that the United States District Court for the District of Massachusetts, Judge William G. Young, following a Nov. 6, 2006 jury decision, ruled in favor of MEEI on claims of unjust enrichment and unfair trade practices against QLT Inc.

11 Jul 2007

Incretin-based therapy offers alternative option for treating type 2 diabetes

A review of previous studies indicates that use of a class of medications known as “incretin-based therapy”, which act via certain pathways that affect glucose metabolism may provide modest effectiveness and favorable weight change outcomes for the treatment of type 2 diabetes and may represent an alternative to other hypoglycemic therapies.

11 Jul 2007

Catalyst Pharmaceutical Partners starts U.S. phase II trial of CPP-109 in patients with cocaine dependence

Catalyst Pharmaceutical Partners, Inc. a specialty pharmaceutical company that acquires or in-licenses, develops and commercializes prescription drugs for the treatment of drug addiction, today announced that it has initiated its randomized, double-blind, placebo-controlled U.S. Phase II clinical trial of CPP-109 in patients with cocaine dependence.

11 Jul 2007

Hydroxychloroquine may reduce risk of diabetes in patients with rheumatoid arthritis

Preliminary research suggests that use of the anti-malarial drug hydroxychloroquine may help reduce the risk of the development of diabetes in patients with rheumatoid arthritis, according to a study in the July 11 issue of JAMA .

11 Jul 2007

Discovery of gallstone gene

Scientists at the University of Bonn, together with colleagues from Romania, have discovered a gene variant that significantly increases the risk of developing gallstones (Hepatology No. 46, 11 July 2007, DOI 10.1002/hep.21847).

11 Jul 2007

Uncooked fish linked with liver cancer in Asia

An age old preference for eating uncooked fish dishes like koi-pla puts people in SE Asia at risk of ingesting trematodes that can cause a type of liver cancer called cholangiocarcinoma (cancer of the bile ducts), say researchers in this week's PLoS Medicine.

10 Jul 2007

No compelling evidence that meditation has therapeutic value

While it's not likely to do you any harm, there is also no compelling evidence that meditation has therapeutic value, says a new report from the University of Alberta.

10 Jul 2007

Scientists take exciting approach for attacking cancers

A new study identifies a combination therapy that may sensitize human cancer cells to a promising treatment currently being used in clinical trials.

10 Jul 2007

National study to treat addiction to prescription pain medications

Researchers funded by the National Institute on Drug Abuse (NIDA), part of the National Institutes of Health, launched the first large-scale national study evaluating a treatment for addiction to prescription opioid analgesics (i.e., painkillers) such as Vicodin and OxyContin.

10 Jul 2007

MacroGenics investigational new drug for West Nile vrus monoclonal antibody is active

MacroGenics has announced that the company's investigational new drug (IND) application to the U.S. Food and Drug Administration for its monoclonal antibody targeted to West Nile Virus is now active.

10 Jul 2007

Breast cancers to be more aggressive in African-American women

A study of more than 2,200 women at the Kimmel Cancer Center at Jefferson in Philadelphia shows that African American women have more advanced breast cancer at the time of diagnosis than Caucasian women.

10 Jul 2007

ERG gene's activity points to more lethal subtype of acute myeloid leukemia

A new study shows that the activity of a particular gene can identify people who have a more lethal form of acute myeloid leukemia, singling out those patients who should receive more intense therapy.

10 Jul 2007

Tips to help baby boomers exercise without injury

Sure, you remember the way you could stretch a single into a double, smash an unstoppable serve over the net or fast-break for an easy two points.

10 Jul 2007

Gene therapy offers promising approach to tackle pancreatic cancer

A molecularly engineered therapy selectively embeds a gene in pancreatic cancer that shrinks or eradicates tumors, inhibits metastasis, and prolongs survival with virtually no toxicity, researchers from The University of Texas M. D. Anderson Cancer Center report in the July 9 edition of Cancer Cell.

10 Jul 2007