Antibiotic News and Research

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Antibiotics are drugs used to treat infections caused by bacteria and other microorganisms.

Linezolid proves effective in treating drug-resistant TB

When tested in patients hospitalized with extensively drug-resistant tuberculosis (XDR-TB) unresponsive to previous treatment, linezolid, an antibiotic used to treat severe bacterial infections, proved largely effective when added to the patients' ongoing TB treatment regimen.

19 Oct 2012

Positive results from PROLOR's Rpeg preclinical toxicology study

PROLOR Biotech, Inc. today announced positive results from a preclinical toxicology study designed to assess the safety and tolerability of PROLOR's proprietary long-acting reversible-pegylation technology.

17 Oct 2012

Antibiotic injections are associated with lower risk of infection in cataract surgery

Intracameral antibiotic injections were associated with a 22-fold reduction in the risk of postoperative infection following cataract surgery when compared with the standard post-operative treatment of antibiotic eyedrops, according to a Kaiser Permanente study.

16 Oct 2012

Researchers develop two ultra-rapid tests for diagnosis of antibiotic resistance

With their excellent sensitivity and specificity, the use of these extremely efficient tests on a world-wide scale would allow us to adapt antibiotic treatments to the individual's needs and to be more successful in controlling antibiotic resistance, particularly in hospitals.

15 Oct 2012

Inhaled corticosteroids increase Staphylococcus pneumoniae infection risk

Regular use of inhaled corticosteroids by asthmatic children increases their risk for oropharyngeal colonization with Staphylococcus pneumoniae almost fourfold, research suggests.

10 Oct 2012

Mayo researchers discover new therapy for patients with neuromyelitis optica

Mayo Clinic researchers have identified a new therapy for patients with neuromyelitis optica that appears to stop inflammation of the eye nerves and spinal cord. NMO is a debilitating central nervous system disorder that is often misdiagnosed as multiple sclerosis (MS).

10 Oct 2012

IspH protein accepts two completely different classes of molecules as partners

The iron-sulfur protein IspH plays a central role in the terpene metabolism of several pathogens. The mechanism of the reaction provides an approach for developing new antibiotics, particularly against malaria and tuberculosis. While researching this enzyme, biochemists at the Technische Universitat Munchen discovered a previously unknown reaction: IspH accepts two completely different classes of molecules as partners.

10 Oct 2012

Women more likely to develop UTI after pelvic-floor surgery

Women who have a positive urine culture test on the day of surgery for a pelvic-floor disorder are more likely to have a urinary tract infection (UTI) in the first six weeks after the procedure.

9 Oct 2012

FDA task force to examine solutions to improve, speed antibiotic research

"One of the most urgent global public health problems is the increasing capability of bacteria to resist antibiotic drugs," a Washington Post editorial states.

8 Oct 2012

Merck receives non-exclusive license to use Delphi StabyExpress technology

Delphi Genetics SA has announced today a broad licensing agreement with a subsidiary of Merck & Co., Inc., known as MSD outside the United States and Canada, for the use of the StabyExpress technology, which allows high yield, cost effective protein expression without the use of antibiotics.

8 Oct 2012

Positive results from Cempra's IV solithromycin Phase 1 study

Cempra, Inc., a clinical-stage pharmaceutical company focused on developing antibiotics to meet critical medical needs in the treatment of bacterial infectious diseases, today announced results of its Phase 1 study of intravenous (IV) solithromycin in healthy subjects. The study demonstrated that IV solithromycin was well tolerated, showed a favorable pharmacokinetic profile (PK) and achieved relevant plasma concentrations.

8 Oct 2012

Researchers discover smallest and fastest-known RNA switches

A University of Michigan biophysical chemist and his colleagues have discovered the smallest and fastest-known molecular switches made of RNA, the chemical cousin of DNA. The researchers say these rare, fleeting structures are prime targets for the development of new antiviral and antibiotic drugs.

8 Oct 2012

Progress toward preventing initial and recurrent episodes of C. diff infection

Surgeons are making progress toward preventing initial and recurrent episodes of clostridium difficile colitis (C. difficile or C. diff), a vicious bacterial infection that is estimated to affect about 336,000 people each year, typically patients on antibiotics.

6 Oct 2012

Diabecline wins Drug Store News Best New Product award

Diabecline first aid antibiotic, offered by pharmaCline, has been named the winner of the Drug Store News Best New Product award.

5 Oct 2012

Antibiotic proved to be Achilles’ heel for some

US clinicians have identified patients at particular risk for Achilles injury while using quinolones.

4 Oct 2012

Penn researchers to begin Microbion's BisEDT gel Phase 2 trials in post-surgical orthopedic infections

A team of researchers led by Samir Mehta, MD, chief of the Orthopaedic Trauma & Fracture Service at the Perelman School of Medicine at the University of Pennsylvania, has received a $2.5 million grant from the Congressionally Directed Medical Research Program (CDMRP), provided through the U.S. Department of Defense (DoD), to begin Phase 2 human trials of a study that examines the effective treatment of post-surgical orthopedic infections using Microbion Corporation's topical BisEDT drug.

4 Oct 2012

LpxC-1 can effectively treat antibiotic-resistant infections

A new type of antibiotic can effectively treat an antibiotic-resistant infection by disarming instead of killing the bacteria that cause it. Researchers report their findings in the October 2 issue of mBio-, the online open-access journal of the American Society for Microbiology.

3 Oct 2012

‘Hygiene hypothesis’ updated to ‘Old Friends’ hypothesis

A new scientific report out today from the International Scientific Forum on Home Hygiene (IFH) dismantles the myth that the epidemic rise in allergies in recent years has happened because we’re living in sterile homes and overdoing hygiene.

3 Oct 2012

Regional, seasonal variation in US antibiotic use highlights persisting issue

US study results reveal “substantial” quarterly and regional variation in outpatient antibiotic use among older adults, indicating the possible need for targeted programs to reduce unnecessary prescriptions.

1 Oct 2012

Researchers track spread of human invasive non-Typhoidal Salmonella in sub-Saharan Africa

A new study out today (Sunday 30 September) reveals that the emergence and spread of a rapidly evolving invasive intestinal disease, that has a significant mortality rate (up to 45%) in infected people in sub-Saharan Africa, seems to have been potentiated by the HIV epidemic in Africa.

1 Oct 2012