Bone Marrow News and Research

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Bone Marrow is the soft, sponge-like tissue in the center of most bones. It produces white blood cells, red blood cells, and platelets.

Why stem cells divide and develop less vigorously as we age

A comprehensive study from Canada’s Robarts Research Institute has pinpointed two genes that shed significant light on why stem cells divide and develop less vigorously as we age.

2 May 2005

New drug may help treat certain forms of leukemia

A new experimental drug may be effective against a certain form of leukemia resistant to current treatments, research at UT Southwestern Medical Center shows.

2 May 2005

Giving children access to drug clinical trials is crucial, clofarabine approval shows

The accelerated approval of the drug clofarabine to treat relapsed or refractory pediatric acute lymphoblastic leukemia (ALL) demonstrates the importance of offering children rapid access to new treatments through clinical trials, according to investigators at St. Jude Children's Research Hospital. Refractory or relapsed ALL is a disease that resists treatment.

2 May 2005

Pattern of gene expression predicts multiple drug resistance, treatment failure in pediatric leukemia

The discovery of a specific pattern of gene expression linked to multiple-drug resistance of leukemic cells is giving researchers crucial information into why standard therapies fail to cure some children with acute lymphoblastic leukemia (ALL). This finding, from investigators at St. Jude Children’s Research Hospital, could lead to development of drugs that would overcome that resistance.

24 Apr 2005

Increasing benefit seen in novel drug AMN107, that treats Gleevec resistance

An investigational drug is producing powerful responses in patients resistant to Gleevec, the targeted therapy that helps most people diagnosed with chronic myeloid leukemia (CML), an international research team headed by investigators at The University of Texas M. D. Anderson Cancer Center is reporting.

23 Apr 2005

Patient with rare liver condition second ever to survive liver transplant after pregnancy

For Billi Tierney, 30, National Donate Life Month in April has a profound meaning. The first-time mother of Sycamore, Ill., was awaiting anxiously the arrival of her first baby. But she never thought that complications from her pregnancy were going to lead to a week in coma and the urgent need for a liver transplant. Tierney suffered from acute liver fatty of pregnancy, a rare, but serious condition of pregnancy in which there is an excessive accumulation of fat in the liver or liver cells.

23 Apr 2005

Stem cells from adults may cause cancer

Stem cells, often lauded as future cures for numerous diseases, are immature "master" cells that can be programmed to become many kinds of tissue, but experts have known for a long time that stem cells harvested from embryos can turn cancerous and have been linked to leukaemias and breast cancer.

23 Apr 2005

Enzyme that helps trigger the development of leukemia

Scientists at the University of North Carolina at Chapel Hill have identified an enzyme that helps trigger the development of leukemia, a cancer of blood cells.

21 Apr 2005

Gene expression pattern predicts multiple drug resistance

St. Jude Children's Research Hospital discovery of genetic links to multi-drug resistance gives clinicians new insight into the cause of treatment failure and suggests targets for novel anti-leukemic drugs

19 Apr 2005

Method of gene therapy accurately corrects mutations in disease-causing genes

Harnessing the strength of a natural process that repairs damage to the human genome, a researcher from UT Southwestern Medical Center has helped establish a method of gene therapy that can accurately and permanently correct mutations in disease-causing genes.

5 Apr 2005

Method of gene therapy that can accurately and permanently correct mutations in disease-causing genes

4 Apr 2005

Mesoblast moves towards adult stem cell human trials

Exciting Australian adult stem cell company, Mesoblast Limited, today announced that it is set to begin the first human clinical trials using its specialist adult stem cells for orthopaedic and cardiovascular diseases.

30 Mar 2005

Adult stem cells could be used to treat deaf patients in the future

Researchers at Indiana University School of Medicine are several steps closer to the day when a profoundly deaf patient's own bone marrow cells could be used to let him or her hear the world.

28 Mar 2005

Process for disposal of dying neutrophils actively linked to neutrophil production

New research identifies a critical inhibitory step that is a key component of the feedback circuit regulating the balance between neutrophil production and destruction.

23 Mar 2005

How does the body keep the number of neutrophils produced constant in the blood?

Every day, the human body manufactures and destroys about 100 billion neutrophils- the most common type of white blood cell and one of the most highly-produced cells. Neutrophils live about eight hours, are bacteria-eaters and are a key component of the immune system. Without them, the body can be subject to life-threatening infection.

23 Mar 2005

Discovery that sheds new light upon the growth and development of human natural killer (NK) cells

Scientists here have made a major discovery that sheds new light upon the growth and development of human natural killer (NK) cells, powerful but somewhat mysterious components of the body’s immune system that are the first line of defense against cancer and infectious diseases.

23 Mar 2005

Research to improve bone marrow transplant outcomes

The National Marrow Donor Program (NMDP) and its affiliate, the Center for International Blood and Marrow Transplant Research (CIMBTR), are supporting clinical trials to determine the best unrelated marrow and blood cell transplant procedures for patients and donors.

21 Mar 2005

Cancer survival comes at its own price

Patients who hear the dreaded words "you have cancer" invariably look forward to the day the doctor tells them "you're cured." But University of Florida researchers say survival often comes at its own price -- the mind may need mending even after the body heals.

16 Mar 2005

Brewing up potential anti-cancer drugs from green tea

Drinking green tea has a protective effect against some forms of cancer but drinking large amounts can increase the risk of birth defects such as spina bifida – according to previous epidemiological studies.

15 Mar 2005

High-dose radiation and bone marrow transfer treatments on glaucoma-susceptible mice completely blocked development of glaucoma

In a discovery that could point to new treatments for a wide range of neurodegenerative diseases, Jackson Laboratory researchers have found that high-dose radiation and bone marrow transfer treatments on glaucoma-susceptible mice completely blocked the development of glaucoma, by preventing neurodegeneration.

14 Mar 2005

Bone Marrow News and Research

Further Reading

Why stem cells divide and develop less vigorously as we age

New drug may help treat certain forms of leukemia

Giving children access to drug clinical trials is crucial, clofarabine approval shows

Pattern of gene expression predicts multiple drug resistance, treatment failure in pediatric leukemia

Increasing benefit seen in novel drug AMN107, that treats Gleevec resistance

Patient with rare liver condition second ever to survive liver transplant after pregnancy

Stem cells from adults may cause cancer

Enzyme that helps trigger the development of leukemia

Gene expression pattern predicts multiple drug resistance

Method of gene therapy accurately corrects mutations in disease-causing genes

Method of gene therapy that can accurately and permanently correct mutations in disease-causing genes

Mesoblast moves towards adult stem cell human trials

Adult stem cells could be used to treat deaf patients in the future

Process for disposal of dying neutrophils actively linked to neutrophil production

How does the body keep the number of neutrophils produced constant in the blood?

Discovery that sheds new light upon the growth and development of human natural killer (NK) cells

Research to improve bone marrow transplant outcomes

Cancer survival comes at its own price

Brewing up potential anti-cancer drugs from green tea

High-dose radiation and bone marrow transfer treatments on glaucoma-susceptible mice completely blocked development of glaucoma

Discover how SciY empowers scientists

Why use light scattering to analyze proteins and viral vectors?

Changing the landscape of R&D to build clinical success from the ground up

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