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Novel machine learning-based approach used to predict hepatotoxic potential of DNA drug

New classes of therapeutic antisense oligonucleotides can have toxic effects on the liver. A novel machine learning-based approach used to predict the hepatotoxic potential of an antisense drug based on its chemical sequence is presented in Nucleic Acid Therapeutics, a peer-reviewed journal from Mary Ann Liebert, Inc. publishers.

28 Aug 2013

New polymer additives enhance ability of oral drugs to reach bloodstream

All too often, when a person takes a pill full of a potent and effective drug, the drug passes straight through the body, not reaching the organ where it is needed — a waste of money and inconvenient if it is a cold medicine, but potentially dire if it is a treatment for a serious illness.

28 Aug 2013

'Helper cells' improve survival rate of transplanted stem cells, finds study

Like volunteers handing out cups of energy drinks to marathon runners, specially engineered "helper cells" transplanted along with stem cells can dole out growth factors to increase the stem cells' endurance, at least briefly, Johns Hopkins researchers report.

28 Aug 2013

New compound offers way to treat migraine and other disorders of central nervous system

For many migraine sufferers, bright lights are a surefire way to exacerbate their headaches. And for some night-shift workers, just a stroll through a brightly lit parking lot during the morning commute home can be enough to throw off their body's daily rhythms and make daytime sleep nearly impossible. But a new molecule that selectively blocks specialized light-sensitive receptors in the eyes could help both these groups of people, without affecting normal vision.

28 Aug 2013

Novel Parkinson’S Target Uncovered

Researchers from Johns Hopkins and the National Cancer Institute (NCI) highlighted a novel mechanism underlying Parkinson's disease while simultaneously putting to rest a previously held theory regarding progression of the disorder. They also identified a compound that alleviates the disease's symptoms in mice.

27 Aug 2013

Companion diagnostics: an interview with Trevor Hawkins, SVP, Strategy, Innovation and Business Development for Siemens Healthcare Diagnostics

Companion diagnostics is critical in helping to pave the way for personalized medicine, in which the treatment is adapted and precisely tailored to the patient.

From Siemens Healthineers 27 Aug 2013

2ml deep well plate launched by Porvair Sciences

Porvair Sciences has developed the first 96-well round deep well plate that genuinely delivers 2.00 ml liquid capacity / well in an automation compatible SLAS / ANSI footprint. The revolutionary "common wall" design provides a full 2ml round well, round bottom well within a 45mm height limit, thus ensuring full compatibility with most plate handling equipment.

From Porvair Sciences Limited 27 Aug 2013

Mount Sinai scientists receive NIH grant to study clinical benefit of IGF-1 in children with PMS

Scientists at the Seaver Autism Center at the Icahn School of Medicine at Mount Sinai have received a grant from the National Institutes of Health to study Insulin-Like Growth Factor-1, a promising treatment for a subtype of autism called Phelan McDermid Syndrome.

27 Aug 2013

Neurobiologists reveal new approach to correcting visual disorders in children

By discovering the role of key neurons that mediate an important part of vision development, UC Irvine and UCLA neurobiologists have revealed a new approach to correcting visual disorders in children who suffer from early cataracts or amblyopia, also known as lazy eye.

27 Aug 2013

Oxygen-generating compound could preserve muscle tissue after severe injury

The same compound in a common household clothes detergent shows promise as a treatment to preserve muscle tissue after severe injury. Researchers at the Wake Forest Baptist Medical Center's Institute for Regenerative Medicine hope the oxygen-generating compound could one day aid in saving and repairing limbs and tissue.

27 Aug 2013

UAB study points to protein pathway that could lead to new treatments for diabetes

The same protein tells beta cells in the pancreas to stop making insulin and then to self-destruct as diabetes worsens, according to a University of Alabama at Birmingham study published online today in the journal Nature Medicine.

27 Aug 2013

Scientists receive NIH grant to study commercially-available drug for treatment of PMS

Scientists at the Seaver Autism Center at the Icahn School of Medicine at Mount Sinai have received a grant from the National Institutes of Health (NIH) to study Insulin-Like Growth Factor-1 (IGF-1), a promising treatment for a subtype of autism called Phelan McDermid Syndrome (PMS).

26 Aug 2013

Researchers identify compound that eases symptoms of Parkinson's disease

Researchers at Johns Hopkins and elsewhere have brought new clarity to the picture of what goes awry in the brain during Parkinson's disease and identified a compound that eases the disease's symptoms in mice.

26 Aug 2013

UCLA-led study points to simple solution that could save Medicare dollars for patients

As everyone knows, medications are expensive, and even with insurance coverage, patients' out-of-pocket drug costs can be quite hefty. This holds true for individuals with Medicare Part D, also known as the prescription drug benefit, which subsidizes the cost of medications for about 28 million Medicare beneficiaries.

23 Aug 2013

Takeda Launches New Subsidiary In Peru

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22 Aug 2013

MicuRx Pharmaceuticals raises $25 million in Series B financing

MicuRx Pharmaceuticals, Inc., a privately-held biopharmaceutical company developing next-generation antibiotics, today announced it raised $25 million in Series B financing. Led by BVCF, a private equity and growth fund specializing in the life sciences industry, the round also includes existing investors Morningside Group and Devon Park Bioventures.

22 Aug 2013

Research suggests restricting calories may improve success of cancer treatment

New research suggests that restricting calories for a defined period of time may improve the success of cancer treatment, offering valuable new data on how caloric intake may play a role in programmed cancer cell death and efficacy of targeted cancer therapies. Study results were published online today in Blood, the Journal of the American Society of Hematology (ASH).

22 Aug 2013

Oncopeptides launches phase II study to determine efficacy of melflufen in treatement of multiple myeloma

Oncopeptides AB, a company working to enhance oncology therapies, today announced that the first patient has been dosed as part of a Phase II study in multiple myeloma patients with its drug candidate melflufen (previously called J1).

21 Aug 2013

Children with high BPA levels have higher odds of obesity and abnormal waist circumference

Children who have higher levels of Bisphenol A (BPA), a chemical previously used in many products for kids, like baby bottle and plastic toys, had a higher odds of obesity and adverse levels of body fat, according to a new study from University of Michigan researchers.

20 Aug 2013

STAAR Surgical receives regulatory approval for its Visian ICL with CentraFLOW technology in India

STAAR Surgical Company, a leading developer, manufacturer and marketer of implantable lenses and delivery systems for the eye, today announced that it has received regulatory approval to market its Visian Implantable Collamer Lens (ICL) with CentraFLOW technology from the CDSCO in India.

19 Aug 2013

Compound News and Research

Novel machine learning-based approach used to predict hepatotoxic potential of DNA drug

New polymer additives enhance ability of oral drugs to reach bloodstream

'Helper cells' improve survival rate of transplanted stem cells, finds study

New compound offers way to treat migraine and other disorders of central nervous system

Novel Parkinson’S Target Uncovered

Companion diagnostics: an interview with Trevor Hawkins, SVP, Strategy, Innovation and Business Development for Siemens Healthcare Diagnostics

2ml deep well plate launched by Porvair Sciences

Mount Sinai scientists receive NIH grant to study clinical benefit of IGF-1 in children with PMS

Neurobiologists reveal new approach to correcting visual disorders in children

Oxygen-generating compound could preserve muscle tissue after severe injury

UAB study points to protein pathway that could lead to new treatments for diabetes

Scientists receive NIH grant to study commercially-available drug for treatment of PMS

Researchers identify compound that eases symptoms of Parkinson's disease

UCLA-led study points to simple solution that could save Medicare dollars for patients

Takeda Launches New Subsidiary In Peru

MicuRx Pharmaceuticals raises $25 million in Series B financing

Research suggests restricting calories may improve success of cancer treatment

Oncopeptides launches phase II study to determine efficacy of melflufen in treatement of multiple myeloma

Children with high BPA levels have higher odds of obesity and abnormal waist circumference

STAAR Surgical receives regulatory approval for its Visian ICL with CentraFLOW technology in India

Enhancing confidence in chemical ionization spectrometry data eBook

Improving healthcare sustainability through carbon data

A New Approach to Preventing Bladder Cancer Recurrence

Bringing real-time analytics to downstream bioprocess monitoring

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