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Researchers identify a novel bacterial protein that can keep human cells healthy

Researchers at the University of São Paulo (USP) in Brazil, partnering with colleagues in Australia, have identified a novel bacterial protein that can keep human cells healthy even when the cells have a heavy bacterial burden.

9 Nov 2023

COVID Moonshot Consortium makes major breakthrough in antiviral drug discovery

The work of the COVID Moonshot Consortium is being published in the prestigious journal Science on 10 November, revealing their discovery of a potent SARS-CoV-2 antiviral lead compound.

9 Nov 2023

Bio Farma's Bio-TCV typhoid conjugate vaccine licensed in Indonesia following marketing approval

The International Vaccine Institute (IVI), an international organization with a mission to discover, develop, and deliver safe, effective, and affordable vaccines for global health, and Bio Farma, a biotechnology company based in West Java, Indonesia, announced today that Bio Farma's Bio-TCV typhoid conjugate vaccine (TCV) was licensed in Indonesia following marketing approval from Badan Pengawas Obat dan Makanan (BPOM), the national regulatory authority.

9 Nov 2023

Scientists discover kidney-friendly antifungal that evades resistance

In this investigation, researchers produced powerful antifungals of the polyene class without nephrotoxicity.

9 Nov 2023

Charting the future of IBD treatment: From immune modulators to microRNA therapies

In a recent study published in the journal eGastroenterology, researchers delved into the latest therapeutic strategies for managing inflammatory bowel disease (IBD), including ulcerative colitis and Crohn's disease. The paper discusses emerging treatments ranging from immune-modulating drugs and biologics to novel approaches like microRNA upregulators and stem cell therapies, highlighting the need for precision medicine in IBD care.

8 Nov 2023

Cannabis use alters DNA methylation, with implications beyond smoking effects

A large-scale meta-analysis in Molecular Psychiatry reveals that lifetime cannabis use is associated with DNA methylation changes in peripheral blood, which could have implications for understanding the long-term health effects of cannabis consumption.

8 Nov 2023

Patients with advanced HER2-positive breast cancer live longer if treated with pyrotinib, trial shows

Patients with HER2-positive breast cancer that has started to spread to other parts of the body survive for longer if they are treated with a new drug called pyrotinib, according to results from the longest follow-up of the PHOEBE randomized clinical trial in China.

8 Nov 2023

Study unravels molecular basis of chronic pain transition

Researchers from the Center for Translational Immunology at University Medical Center Utrecht (the Netherlands) have identified that a transient inflammatory pain causes mitochondrial and redox changes in sensory neurons that persist beyond pain resolution.

8 Nov 2023

Inhibitory interneurons play a crucial role in fear memory expression and recall

Memory, a fundamental tool for our survival, is closely linked with how we encode, recall, and respond to external stimuli.

8 Nov 2023

Study sheds new light on the variety of cellular causes of rheumatoid arthritis

Rheumatoid arthritis (RA) is an autoimmune disease characterized by inflammation that leads to pain, joint damage, and disability, which affects approximately 18 million people worldwide.

8 Nov 2023

Scientists unravel the mystery of how cells keep glutathione levels in check

If a delivery person leaves a package on your front step without pinging you, you likely won't know it's there.

8 Nov 2023

UC Riverside scientists slow progression of Huntington's disease in flies and worms

Huntington's disease causes involuntary movements and dementia, has no cure, and is fatal. For the first time, UC Riverside scientists have shown they can slow its progression in flies and worms, opening the door to human treatments.

8 Nov 2023

Diabetes breakthrough: Scientists uncover novel route to stimulate beta cell growth

Researchers at Weill Cornell Medicine have uncovered a novel route to stimulate the growth of healthy insulin-producing pancreatic beta cells in a preclinical model of diabetes.

8 Nov 2023

Simultaneous inhibition of two proteins may be a new strategy for tackling triple-negative breast cancer

Researchers at the Centre for Genomic Regulation and Vall d'Hebron Institute of Oncology have shown that the simultaneous inhibition of two different proteins may represent a new strategy for tackling triple-negative breast cancer, the most aggressive and drug-resistant form of breast cancer.

8 Nov 2023

New prodrug approach enhances drug delivery to brain cells

A new study from the University of Eastern Finland shows that the delivery of drugs into the brain, and especially into glial cells, can be enhanced with prodrugs that temporarily incorporate thyroxine or a thyroxine-like molecule.

8 Nov 2023

Temperature plays crucial role in virus DNA release and infection

Researchers at Lund University, together with colleagues at the NIST Synchrotron Facility in the USA, have mapped on an atomic level what happens in a virus particle when the temperature is raised.

8 Nov 2023

New drug shows exciting promise for the treatment of ALS

In science, a simple but thorough observation can kick-start the most surprising findings. Researchers at the Hollings Cancer Center at the Medical University of South Carolina noticed that mice lacking a protein of interest in cancer research were showing visible signs of abnormal motor functions as they aged, including loss of coordination and strength.

8 Nov 2023

The effect of vegetarian diets on sports performance

The effects of vegetarian and omnivorous diets on athletic performance.

8 Nov 2023

Pharmacogenomics holds promise for personalized dementia therapies

Pharmacogenomics-based studies in the research for personalized therapeutics for dementia

8 Nov 2023

Immune imprinting: The crux of waning COVID-19 booster effectiveness against new variants

The study in Nature Microbiology reviews the concept of immune imprinting and its influence on antibody responses to SARS-CoV-2, highlighting challenges for COVID-19 booster vaccination efficacy against emerging variants. Researchers suggest that understanding immune imprinting is crucial for developing vaccines that elicit broad and lasting immune protection.

7 Nov 2023

Protein C News and Research

Researchers identify a novel bacterial protein that can keep human cells healthy

COVID Moonshot Consortium makes major breakthrough in antiviral drug discovery

Bio Farma's Bio-TCV typhoid conjugate vaccine licensed in Indonesia following marketing approval

Scientists discover kidney-friendly antifungal that evades resistance

Charting the future of IBD treatment: From immune modulators to microRNA therapies

Cannabis use alters DNA methylation, with implications beyond smoking effects

Patients with advanced HER2-positive breast cancer live longer if treated with pyrotinib, trial shows

Study unravels molecular basis of chronic pain transition

Inhibitory interneurons play a crucial role in fear memory expression and recall

Study sheds new light on the variety of cellular causes of rheumatoid arthritis

Scientists unravel the mystery of how cells keep glutathione levels in check

UC Riverside scientists slow progression of Huntington's disease in flies and worms

Diabetes breakthrough: Scientists uncover novel route to stimulate beta cell growth

Simultaneous inhibition of two proteins may be a new strategy for tackling triple-negative breast cancer

New prodrug approach enhances drug delivery to brain cells

Temperature plays crucial role in virus DNA release and infection

New drug shows exciting promise for the treatment of ALS

The effect of vegetarian diets on sports performance

Pharmacogenomics holds promise for personalized dementia therapies

Immune imprinting: The crux of waning COVID-19 booster effectiveness against new variants

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

Advancing Intracellular Delivery with LumiPore®

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