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Hyperactivated brain cells following social trauma impair social reward and promote social avoidance

Past social trauma is encoded by a population of stress/threat-responsive brain cells that become hyperactivated during subsequent interaction with non-threatening social targets. As a consequence, previously rewarding social targets are now perceived as social threats, which promotes generalized social avoidance and impaired social reward processing that can contribute to psychiatric disorders, according to a study conducted by researchers at the Brain and Body Research Center at Mount Sinai and published November 30 in Nature.

30 Nov 2022

Research findings may offer a new potential therapeutic target for Alzheimer’s disease

A new study links a gene concentrated in the brain's cleanup cells, known as microglia, to the inflammation that has increasingly emerged as a key mechanism contributing to Alzheimer's disease.

30 Nov 2022

Terminally ill patients across the West Midlands still living in fear of early death from Covid-19

People with terminal illness across the West Midlands are still living in fear of catching Covid-19 and dying early according to research.

29 Nov 2022

An unexplained injury discovered after eye surgery. What should happen next?

When Jerry Bilinski, a 67-year-old retired social worker, scheduled cataract surgery with Carolina Eye Associates near his home in Fayetteville, North Carolina, he expected no drama, just a future with better vision.

29 Nov 2022

Low-dose CT screening improves survival rate of lung cancer patients

Diagnosing early-stage lung cancer with low-dose computed tomography (CT) screening drastically improves the survival rate of cancer patients over a 20-year period, according to a large-scale international study being presented by Mount Sinai researchers at the annual meeting of the Radiological Society of North America.

22 Nov 2022

Acupuncture significantly improves lower back or pelvic pain during pregnancy

Acupuncture can significantly relieve the lower back and/or pelvic pain frequently experienced by women during their pregnancy, suggests a pooled data analysis of the available evidence, published in the open access journal BMJ Open.

22 Nov 2022

Key Alzheimer’s gene alters the way cholesterol moves around the brain, research finds

A gene recognized as the strongest risk factor for Alzheimer's disease (AD) alters the way cholesterol moves around the brain and as we age, this altered movement likely contributes to loss of learning and memory, a team of researchers from the Icahn School of Medicine at Mount Sinai and the Massachusetts Institute of Technology reports.

16 Nov 2022

Researchers identify 35 genes that are highly expressed in patients with long-term Lyme disease

Researchers at the Icahn School of Medicine at Mount Sinai in New York have identified 35 genes that are particularly highly expressed in people with long-term Lyme disease.

15 Nov 2022

Scientists validate safe surgical access to the central core of human cochlea

An international team of scientists and surgeons, including researchers from the University of Sheffield, has, for the first time, validated safe surgical access to the central core of the human cochlea.

10 Nov 2022

Study helps understand the basis of sex differences in SARS-CoV-2 infection

Significant immunological differences between young men and women were shown to mediate sex differences in the responses to the virus that causes COVID-19, according to a collaborative study of nearly 3,000 young, healthy members of the U.S. Marine Corps.

8 Nov 2022

Researchers identify therapies for multiple myeloma patients whose cancer relapses after CAR-T

Mount Sinai and Memorial Sloan Kettering Cancer Center (MSK) researchers have identified therapies that can help patients with the blood cancer multiple myeloma who try an immunotherapy known as CAR-T only to find their cancer coming back afterwards.

4 Nov 2022

Novel nasal cleansing system increases comfort and compliance in sleep apnea patients using CPAP

A novel nasal cleansing system (NasoClenzTM, Silicon Valley Innovations, Sunnyvale, CA) reduced bacterial colonization while increasing comfort and compliance in patients that use continuous positive airway pressure (CPAP) to treat sleep apnea, according to results of a clinical evaluation recently presented at the American College of Surgeons Clinical Congress.

3 Nov 2022

Sophisticated tool helps measure exposure levels to PFAS

A novel metric that estimates our "burden," or cumulative exposure, to a family of thousands of synthetic chemicals that we encounter in everyday life with potentially adverse health impacts, has been created by a team of researchers at Mount Sinai.

2 Nov 2022

Study provides more nuanced insights into RNA modifications by A-to-I editing during brain development

Mount Sinai researchers have cataloged thousands of sites in the brain where RNA is modified throughout the human lifespan in a process known as adenosine-to-inosine (A-to-I) editing, offering important new avenues for understanding the cellular and molecular mechanisms of brain development and how they factor into both health and disease.

1 Nov 2022

BCRF renews funding to support the development of novel therapeutics for triple-negative breast cancer

The Breast Cancer Research Foundation (BCRF) has renewed its funding to Elisa Port, MD, and Hanna Irie, MD, PhD, to study new therapeutic approaches that target aggressive triple-negative breast cancer.

31 Oct 2022

New hearing screening system for newborns uses a smartphone and low-cost earbuds

Newborns across the United States are screened to check for hearing loss. This test is important because it helps families better understand their child's health, but it's often not accessible to children in other countries because the screening device is expensive.

31 Oct 2022

New probe design offers promises for many imaging applications in biological and biomedical research

Microendoscopes are the cornerstone of modern medical diagnostics - they allow us to see what we could not even describe two decades ago.

28 Oct 2022

Study finds persistent disparities in access to prenatal care among pregnant people

Immigrant pregnant people faced persistent inequities in obtaining timely prenatal care as compared with native-born pregnant people in the United States over an eight-year period, a factor that could be contributing to longstanding health disadvantages, according to an analysis published in JAMA Network Open on October 28.

28 Oct 2022

New approach to immunotherapy provokes a robust anti-tumor immune response in preclinical models

A new approach to cancer immunotherapy that uses one type of immune cell to kill another - rather than directly attacking the cancer - provokes a robust anti-tumor immune response that shrinks ovarian, lung, and pancreatic tumors in preclinical disease models, according to researchers at the Icahn School of Medicine at Mount Sinai in New York.

25 Oct 2022

Emergence delirium does not affect children's behavior three months after surgery

Emergence delirium - a confused state during recovery from anesthesia that may include disorientation, hallucination, restlessness and purposeless hyperactivity - does not affect a child's behavior three months after surgery, according to research being presented at the ANESTHESIOLOGY® 2022 annual meeting.

24 Oct 2022