Ex Vivo News and Research

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Scientists develop 3-D organoid to unravel immune response during infection

What if you could design an adaptable, biomaterials-based model of an organ to track its immune response to any number of maladies, including cancer, transplant rejection and the Zika virus? The lab of Ankur Singh, assistant professor in the Sibley School of Mechanical and Aerospace Engineering, has asked - and begun to answer - that very question.

6 Jan 2017

Scientists developing magnetic stem cells to fight cancer

Scientists from the Tomsk Polytechnic University's Laboratory of Novel Dosage are developing a technology to control mesenchymal stem cells of patients.

29 Dec 2016

Sphere Medical launches next generation Proxima for bedside blood gas and glucose analysis

Sphere Medical, an innovative company in critical care monitoring and diagnostics equipment, has launched its next generation CE-marked Proxima system.

17 Dec 2016

New research shows chitosan bioplastics may help seal tissue tears or other injuries

Chitosan, a biomaterial derived from the chitin shells of crustaceans and insects, has already been developed by scientists at Harvard's Wyss Institute for Biologically Inspired Engineering into an environmentally-friendly and fully biodegradable substitute for plastic.

29 Nov 2016

New technique could increase availability of donor lungs by increasing preservation time

Extending transplant time could reduce geographical limitations on donors and recipients and allow more time for organ assessment and repair

21 Nov 2016

Preserving donor lungs for longer time may provide greater flexibility during transplants

A new method which doubles the usual time donor lungs can remain outside the body can benefit patients, staff and allow retrieval of donor lungs across greater geographical areas, says a study published in The Lancet Respiratory Medicine.

17 Nov 2016

Scientists create comprehensive rat brain atlas to guide surgical procedures

Boris Odintsov, senior research scientist at the Biomedical Imaging Center at the Beckman Institute for Advanced Science and Technology at the University of Illinois in Urbana-Champaign, and Thomas Brozoski, research professor at the Southern Illinois University School of Medicine in Springfield, have created a comprehensive, interactive rat brain atlas.

21 Oct 2016

Optical and PET/CT activity-based probes could help in non-invasive imaging of atherosclerotic plaques

Researchers at Stanford University have demonstrated for the first time the use of a dual optical and PET/CT activity-based probe to detect atherosclerotic plaques. The study is published in the October issue of the Journal of Nuclear Medicine.

20 Oct 2016

MILabs launches EXIRAD-3D quantitative autoradiography for fast imaging of tissue samples

EXIRAD-3D, MILabs’ new micron-resolution Single Photon Emission Computed Tomography (SPECT) technology, dedicated for imaging ex-vivo tissue samples is being launched by MILabs at the EANM congress in Barcelona.

17 Oct 2016

Overcoming gene silencing barriers to target neurological conditions: an interview with Dr Errol de Souza

Many gene mutations that cause neurological disorders have been identified. For example, in a rare neurological disorder such as Huntington’s disease, an autosomal dominant mutation through expansion of CAG (cytosine-adenine-guanine) triplet repeats in the gene coding for the Huntingtin protein results in abnormal protein production.

1 Aug 2016

Researchers develop first placenta-on-a-chip to model interface between mother and fetus

Researchers at the University of Pennsylvania have developed the first placenta-on-a-chip that can fully model the transport of nutrients across the placental barrier.

26 Jul 2016

Study shows how genetic variants control immune cell response to pathogens

A study that is first in its kind and published in Nature Medicine today has looked at how far genetic factors control the immune cell response to pathogens in healthy individuals.

4 Jul 2016

Gene editing technology helps excise segment of HIV-1 DNA from genomes of living animals

Using gene editing technology, researchers at the Lewis Katz School of Medicine at Temple University have, for the first time, successfully excised a segment of HIV-1 DNA - the virus responsible for AIDS - from the genomes of living animals.

20 May 2016

New bio-mimicry method allows scientists to track cells in vivo using MRI during preclinical, clinical trials

Researchers led by Carnegie Mellon University Professor of Biological Sciences Chien Ho have developed a new method for preparing mesenchymal stem cells (MSCs) that not only leads to the production of more native stem cells, but also labels them with a FDA approved iron-oxide nanoparticle (Ferumoxytol).

18 May 2016

Scientists prove effectiveness of gene editing system in eliminating HIV from DNA of CD4+ T-cells

In 2014, a team of researchers in the Lewis Katz School of Medicine at Temple University became the first to successfully eliminate the HIV-1 virus from cultured human cells.

12 May 2016

Exercise may promote cardiovascular health in chronically stressed individuals

Constant stress is associated with signs of poor blood vessel health and increased risk of cardiovascular disease. New research presented today at the Experimental Biology 2016 meeting in San Diego finds that aerobic exercise kept the blood vessels of stressed rats working normally.

6 Apr 2016

Researchers explore rapid changes in oxygen levels as aggravating factors in lung failure

Mechanical ventilation can contribute to lung damage by inducing rapid changes in oxygen levels. Researchers at the Medical University of Vienna are now conducting studies for the first time into the significance of these changes as aggravating factors in lung failure.

5 Apr 2016

Researchers demonstrate novel method for imaging engineered nanoparticles in tissues

As a testament to Governor Andrew Cuomo’s leadership in developing an unparalleled research and development ecosystem in New York State, Sara Brenner, MD, MPH and her colleagues at SUNY Polytechnic Institute (SUNY Poly), the George Washington School of Medicine and Health Sciences, and Stony Brook University have demonstrated a novel method for the rapid visualization and identification of engineered nanoparticles in tissues.

28 Mar 2016

Transient contractions could be new target for therapeutic intervention in urinary bladder dysfunction

Researchers at the University of Vermont College of Medicine have made a discovery that helps explain how we know when to empty our bladders and may lead to new therapeutic interventions for bladder dysfunction.