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Small molecule drug can attenuate the triggers of neuroinflammation, preclinical study shows

Neuroinflammation can worsen outcomes in stroke, traumatic brain injury, or spinal cord injury, as well as accelerate neurodegenerative diseases like ALS, Parkinson's, or Alzheimer's. This suggests that limiting neuroinflammation may represent a promising new approach to treat neurological diseases and neuropathic pain that are driven by neuroinflammation.

24 Sep 2021

Immune cells in the brain join together to break down toxic proteins more quickly

To break down toxic proteins more quickly, immune cells in the brain can join together to form networks when needed. This is shown by a joint study of the University of Bonn, the German Center for Neurodegenerative Diseases, and the Institut François Jacob in France.

23 Sep 2021

NIH researchers develop a detailed cellular map of chronic MS lesions

Chronic lesions with inflamed rims, or "smoldering" plaques, in the brains of people with multiple sclerosis (MS) have been linked to more aggressive and disabling forms of the disease.

10 Sep 2021

Green tea extract and cocoa-supplemented diets improve survival rate of aging mice

Aging-US published "Beneficial effects of dietary supplementation with green tea catechins and cocoa flavanols on aging-related regressive changes in the mouse neuromuscular system" which reported that green tea extract (GTE) and cocoa-supplemented diets significantly improved the survival rate of mice.

1 Sep 2021

Research highlights the importance of meninges for brain development and pathology

A new study, led by researchers at the University of Gothenburg, have generated the first comprehensive transcriptional atlas of neonatal mouse meningeal leukocytes, under normal conditions and after perinatal brain injury.

31 Aug 2021

Novel coating technology increases lifespan and stability of implantable devices

Various human implantable medical devices have been developed in recent years, and they are being used in clinical filed. These devices include brain–machine interfaces, in which a chip is implanted into the brain to enable humans to move machines using only their thoughts, and deep brain stimulators for treating Parkinson's disease and other brain diseases.

31 Aug 2021

3D-printed tumors potentially next step in personalized medicine

Scientists at Tel Aviv University have successfully printed an entire active and viable brain tumor using a three-dimensional or 3D printer for the first time.

20 Aug 2021

Scientists identify the main components driving amyloid beta-associated synapse degeneration

Healthy adult brains are endowed with a vast number of synapses, structures that relay signals across nerve cells to enable communications, information processing and storage throughout the nervous system.

18 Aug 2021

Researchers create the first 3D-bioprinted model of active glioblastoma tumor

A scientific achievement for researchers at Tel Aviv University: printing an entire active and viable glioblastoma tumor using a 3D printer.

18 Aug 2021

Skin cells could provide better understanding of molecular mechanisms of frontotemporal dementia

A new study from the University of Eastern Finland suggests that skin fibroblasts from frontotemporal dementia patients may be useful in investigating underlying disease mechanisms as well as in biomarker and drug research.

12 Aug 2021

Beige fat cells mediate subcutaneous fat's brain protection from dementia

Beige is considered a calming paint color, and scientists have new evidence that beige fat has a similar impact on the brain, bringing down the inflammation associated with the more common white fat and providing protection from dementia.

10 Aug 2021

Study finds altered brain gene expression patterns in people with opioid use disorder

The epidemic of opioid abuse affects millions of people worldwide, but researchers know surprisingly little about the molecular changes caused by opioids in the human brain.

10 Aug 2021

Previously unknown brain repair process could be harnessed to treat seizures and epilepsy

University of Virginia School of Medicine researchers have discovered a previously unknown repair process in the brain that they hope could be harnessed and enhanced to treat seizure-related brain injuries.

23 Jul 2021

Researchers identify immune protein linked to rare neurodegenerative disease

UT Southwestern researchers have identified an immune protein tied to the rare neurodegenerative condition known as Niemann-Pick disease type C.

21 Jul 2021

How SARS-CoV-2 infects the brain

While there is no official explanation on how SARS-CoV-2 travels to the brain, a new review published in the journal Fluids and Barriers of the CNS concluded that there is insufficient evidence on COVID-induced neurological problems coming from a direct invasion of SARS-CoV-2 into the brain.

20 Jul 2021

Component derived from turmeric essential oil exhibits neuroprotective effects

Researchers from Kumamoto University, Japan have found that a component derived from turmeric essential oil, aromatic turmerone (ar-turmerone), and its derivatives act directly on dopaminergic nerves to create a neuroprotective effect on tissue cultures of a Parkinson's disease model.

14 Jul 2021

Study identifies specialized immune cells that sculpt inhibitory neurons to regulate brain wiring

From the bark of a puppy to the patter of rain against the window, our brains receive countless signals every second. Most of the time, we tune out inconsequential cues--the buzz of a fly, the soft rustle of leaves in the tree--and pay attention to important ones--the sound of a car horn, a bang on the door.

7 Jul 2021

High levels of protein linked with heart health could protect against Alzheimer's-like brain damage

By the time people with Alzheimer's disease start exhibiting difficulty remembering and thinking, the disease has been developing in their brains for two decades or more, and their brain tissue already has sustained damage. As the disease progresses, the damage accumulates, and their symptoms worsen.

21 Jun 2021

Study creates a new model of Alzheimer's disease progression

Alzheimer's disease is the most common form of dementia and is characterized by neurodegeneration in regions of the brain involved in memory and learning. Amyloid beta and tau are two toxic proteins that build up in disease and cause eventual neuronal death, but little is known about how other cells in the brain react during disease progression.

14 Jun 2021

Researchers identify genomic cellular map associated with hippocampal sclerosis

A multidisciplinary team led by researchers from the Spanish Research Council identifies the genomic cellular map associated with hippocampal sclerosis, a major histopathological condition of temporal lobe epilepsy.

8 Jun 2021