Mouse Model News and Research

RSS

Short peptides show promise in blocking breast cancer metastasis

A surgeon can excise breast cancer from the body, but even the most skilled scalpel may not be able to remove every cell - especially when the cells have spread from the original disease site elsewhere in the body.

13 Jun 2025

Yellow pigment linked to protection against severe malaria

New research suggests that a pigment that causes yellowing of the skin, or jaundice, may help protect people from the most severe consequences of malaria.

13 Jun 2025

Chronic hyponatremia causes anxiety-like behaviors by disrupting brain chemistry

Hyponatremia, or low blood sodium concentration, is typically viewed as a symptomless condition-until recently.

12 Jun 2025

Exercise targets specific brain cells to protect against Alzheimer’s

Using advanced single-nuclei RNA sequencing (snRNA-seq) and a widely used preclinical model for Alzheimer's disease, researchers from Mass General Brigham and collaborators at SUNY Upstate Medical University have identified specific brain cell types that responded most to exercise.

12 Jun 2025

New 3D model reveals hidden role of stem cells in sense of smell

Using a newly devised, three-dimensional model to study the regeneration of nerve tissue in the nose, researchers at Tufts University School of Medicine and the Graduate School of Biomedical Sciences (GSBS) and colleagues have discovered that one type of stem cell thought to be dormant may play a more significant role in preserving the sense of smell than originally believed.

11 Jun 2025

Manganese-coordinated lipid nanoparticles boost VZV vaccine-induced T cell responses

Announcing a new article publication for Zoonoses journal. Because varicella zoster virus (VZV) infections are continually increasing, vaccine efficacy must be enhanced.

10 Jun 2025

Study reveals the genetic underpinnings of a rare and aggressive ovarian cancer

A new study explains the genetic underpinnings of a rare and aggressive form of ovarian cancer – and offers a potential pathway for new treatments.

9 Jun 2025

Study reveals mechanisms behind antibiotic-related immune disruptions in infants

In 2017, scientists at Cincinnati Children's revealed that using antibiotics to protect newborns from dangerous infections often comes with a long-term consequence-a permanently underdeveloped immune system that can make children prone to poor outcomes from future lung infections.

9 Jun 2025

Study aims to demystify the immune toxicity triggered by osimertinib-ICI co-treatment

Non-small cell lung cancer (NSCLC) accounts for the majority of lung cancer cases and remains a leading cause of cancer mortality worldwide.

6 Jun 2025

SIRT6 identified as a critical safeguard of spinal disc health

Low back pain is the most prevalent musculoskeletal condition worldwide and is closely tied to the progressive degeneration of intervertebral discs.

5 Jun 2025

Switching to a low fat diet slows pancreatic precancer development in mice

Pancreatic cancer is one of the deadliest forms of cancer, killing 87% of patients within five years. Previous studies have shown that obesity can increase pancreatic cancer risk by around 50%.

4 Jun 2025

New mouse model sheds light on smell loss and neural regeneration

A new study suggests that stem cells thought to be dormant may offer clues to why our sense of smell declines or is lost.

3 Jun 2025

Pitt researchers challenge a decades-old assumption about brain plasticity

A new study from Pitt researchers challenges a decades-old assumption in neuroscience by showing that the brain uses distinct transmission sites - not a shared site - to achieve different types of plasticity.

3 Jun 2025

New combination treatment offers hope for immune checkpoint blockade resistant skin cancers

A study has revealed why some patients don't respond to immune checkpoint blockade (ICB) therapy for solid cancer tumors and identifies a new combination treatment.

2 Jun 2025

Obesity associated with anxiety and cognitive impairment in mice

With rates of obesity and anxiety both on the rise-especially among younger Americans-new research suggests that the two conditions may be connected through interactions between the gut and the brain.

1 Jun 2025

New mouse model sheds light on molecular triggers of aortic dissection

Due to the sudden rupture of the aortic wall, aortic dissection is a life-threatening condition that requires immediate medical attention, as it can lead to vascular collapse.

29 May 2025

Intestinal bacteria and their metabolites contribute directly to vascular aging

The aging of the innermost cell layer of blood vessels leads to cardiovascular diseases. Researchers at UZH have now shown for the first time that intestinal bacteria and their metabolites contribute directly to vascular aging.

28 May 2025

Fact: You could be inhaling nearly 70,000 plastic particles annually, here's what it means for your health

Airborne microplastics and nanoplastics are increasingly detected in urban environments, with evidence linking inhalation exposure to inflammation, cardiovascular risks, and other health concerns. Researchers highlight urgent needs for improved detection, targeted mitigation strategies, and coordinated global policies to address this emerging threat.