Reactive Oxygen Species (ROS) News and Research

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Noval neuroimaging technique enables detailed insights into mitochondria

Reactive oxygen species are important intracellular signaling molecules, but their mode of action is complex: In low concentrations they regulate key aspects of cellular function and behavior, while at high concentrations they can cause "oxidative stress", which damages organelles, membranes and DNA.

25 Apr 2014

Scientists receive federal grant to track how multi-walled carbon nanotubes interact with human cells

Scientists at The University of Texas at Dallas have received a federal grant to investigate how tiny carbon structures used in the manufacture of many everyday products might affect human health.

22 Apr 2014

Highly advanced imaging method helps to monitor rapid changes in glutathione redox potentials in live cells

In the April issue of Experimental Biology and Medicine a multidisciplinary research team led by Drs. Rex Gaskins and Paul Kenis in the Institute of Genomic Biology (IGB) on the campus of the University of Illinois Urbana-Champaign describe their recent work on subcellular redox homeostasis.

21 Apr 2014

Angelica sinensis polysaccharides alleviate neuronal cell injury caused by oxidative stress

According to traditional Chinese medicine, the roles of Angelica sinensis correlate with tonifying the blood and promoting its circulation. Recent studies have shown that extracts of Angelica sinensis have antioxidative and neuroprotective effects.

10 Apr 2014

New approach could lead to devising alternative tools for cancer therapy

Inducing biological tissue damage with an atmospheric pressure plasma source could open the door to many applications in medicine

26 Mar 2014

Study provides insight into the mechanisms underlying diabetic peripheral neuropathy

Iron overload can lead to cytotoxicity, and it is a risk factor for diabetic peripheral neuropathy. However, the underlying mechanism remains unclear.

13 Mar 2014

Research reveals 2 key mechanisms of oxidative stress regulation

Regulation of oxidative stress is critical to cell survival. New preclinical research from Roswell Park Cancer Institute (RPCI) has revealed two key mechanisms by which oxidative stress is regulated in normal and cancerous cells.

7 Mar 2014

New theory on the causation of type 2 diabetes

At 85, Nobel laureate James D. Watson, the co-discoverer of the double-helix structure of DNA, continues to advance intriguing scientific ideas. His latest, a hypothesis on the causation of type 2 diabetes, is to appear 7 pm Thursday US time in the online pages of The Lancet, the prestigious British medical journal.

4 Mar 2014

New research reveals potential link between alcohol consumption and breast cancer

New research looking at the biological process involved in breast cancer development has strengthened the argument for a potential link between alcohol consumption and the disease.

From The University of Manchester 12 Feb 2014

Researchers examine link between alcohol consumption and breast cancer development

New research looking at the biological process involved in breast cancer development has strengthened the argument for a potential link between alcohol consumption and the disease.

From The University of Manchester 11 Feb 2014

Early onset of dietary treatment may slow down progression of Alzheimer's disease

New research findings indicate that an early onset of dietary treatment may slow down the progression of Alzheimer's disease. The study was conducted on mice, and the results will be published in the February issue of Journal of Nutritional Biochemistry. Researchers from the University of Eastern Finland played a key role in the study, which was carried out as part of the LiPiDiDiet project funded by the European Union.

24 Jan 2014

Early onset of dietary treatment may slow down progression of Alzheimer's, says research

24 Jan 2014

Study shows direct link between metabolism in brain cells and ability to signal information

A new study by scientists at McGill University and the University of Zurich shows a direct link between metabolism in brain cells and their ability to signal information. The research may explain why the seizures of many epilepsy patients can be controlled by a specially formulated diet.

16 Jan 2014

Study uncovers how enzymes could be used to identify predisposition to ROS-related diseases

A UT Arlington chemist doing National Science Foundation-funded research on enzymes that regulate human biology has uncovered characteristics that could be used to identify predisposition to conditions such as heart disease, diabetic ulcers and some types of cancer.

6 Jan 2014

Cardiotoxicity of doxorubicin is mediated through mitochondrial iron accumulation

Doxorubicin is a widely used as a component of chemotherapy regimes; however, the use of doxorubicin is associated with severe cardiotoxicity. It is unclear exactly how doxorubicin promotes cardiotoxicity, but it has been proposed that doxorubicin-associated cardiomyopathy develops as the result of reactive oxygen species (ROS) production and iron accumulation.

2 Jan 2014

Researchers evaluate mangafodipir for relief of oxaliplatin-associated neuropathies

An unfortunate side effect of the platinum-chemotherapy drug oxaliplatin is the development of neurotoxicity, which can adversely affect a patient's quality of life; therefore, the benefit of oxaliplatin-based therapy must be balanced with prevention of neuropathies. Currently, there are no therapeutic interventions available to relieve oxaliplatin-associated neurological symptoms, which are thought to be a result of reactive oxygen species-associated damage.

22 Dec 2013

Decreasing levels of reactive oxygen species can break cycle of unhealing wounds

Chronic wounds affect an estimated 6.5 million Americans at an annual cost of about $25 billion. Further, foot blisters and other diabetic ulcers or sores account for the vast majority of foot and leg amputations in the United States today.

18 Dec 2013

Ligand announces data from preclinical studies on small-molecule oral G-CSF receptor agonist

Ligand Pharmaceuticals Incorporated announced that data from preclinical studies on its granulocyte colony stimulating factor (G-CSF) receptor agonist program were featured in a poster presentation today at the 55th Annual Meeting of the American Society of Hematology in New Orleans.

9 Dec 2013

NIH scientists film early concussion damage and describe brain's response to injury

There is more than meets the eye following even a mild traumatic brain injury. While the brain may appear to be intact, new findings reported in Nature suggest that the brain's protective coverings may feel the brunt of the impact.