Antibodies News and Research

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RIG-1 agonist shows potent antiviral efficacy against SARS-CoV-2 infection

A team of scientists from the United States has recently revealed the antiviral efficacy of stem-loop RNA 14, a RIG-1 agonist, in controlling severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in mice. The compound reduces the risk of severe coronavirus disease 2019 (COVID-19) by inhibiting viral replication in the lower respiratory tract. The study is currently available on the bioRxiv* preprint server.

18 Jun 2021

Combination of interferon-α and nafamostat inhibits SARS-CoV-2 in vivo

A new study, released as a preprint on bioRxiv* server, shows that a combination of the biological interferon-α and the small molecule nafamostat are effective against SARS-CoV-2 infection in vitro, as well as in vivo.

18 Jun 2021

COVID-19 outbreak in Mauritius dominated by new SARS-CoV-2 variant B.1.1.318

Underlining the key role of genomic surveillance in keeping tabs on the spread of SARS-CoV-2, a new medRxiv* preprint shows how a new variant called B.1.1.318 rose to dominance in the small island country of Mauritius, in the Indian Ocean.

18 Jun 2021

Could horse-derived antibody therapy be effective against SARS-CoV-2 variants of concern?

A new study, released as a preprint on the bioRxiv* server, reveals the high neutralizing efficacy of hyperimmune horse serum against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This could prove, if validated, to be a more affordable yet potent therapeutic in reducing the morbidity and mortality caused by this virus.

18 Jun 2021

First insights into human prion disease could help tackle neurodegenerative diseases

Surface features of human prions have been identified for the first time, which may provide key information into treatments of neurodegenerative diseases.

18 Jun 2021

Texas Biomed scientists receive $1 million NIH funding for Ebola research

Scientists have a general idea of how viruses invade and spread in the body, but the precise mechanisms are actually not well understood, especially when it comes to Ebola virus.

18 Jun 2021

Previous SARS-CoV-2 infection, vaccines provide protection against gamma variant, study finds

In early January 2021, travelers returning to Tokyo, Japan, from Amazonas, Brazil, were screened for COVID-19 at the airport. A few days later, the National Institute of Infectious Disease of Japan announced that the travelers had returned with a new variant of the SARS-CoV-2 virus.

18 Jun 2021

Study examines SARS-CoV-2 replication in cells using super-resolution microscopy

Despite tremendous efforts by the global scientific community to curb the spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), by developing more efficient testing protocols, therapies, and vaccines at a rapid pace, relatively little is known about the dynamics of SARS-CoV-2 replication within cells.

18 Jun 2021

Convalescent plasma can improve chances of survival among blood cancer patients with COVID-19

A large, retrospective, multicenter study involving Washington University School of Medicine in St. Louis indicates that convalescent plasma from recovered COVID-19 patients can dramatically improve likelihood of survival among blood cancer patients hospitalized with the virus.

18 Jun 2021

Combination of anti-HER2 breast cancer therapy and checkpoint inhibitor provides no benefit

Adding an immune checkpoint inhibitor to anti-HER2 treatment in breast cancer does not improve pathological complete response (pCR), according to the primary analysis of the IMpassion050 trial presented today during the ESMO Virtual Plenary.

18 Jun 2021

The SARS-CoV-2 virus and its vaccines pose unique challenges

Iranian researchers recently provided a review of the attempts made to develop safe SARS-CoV-2 vaccines. The researchers outlined potential challenges and concerns, including disease enhancement, virus mutation, and public acceptability. Their work is published in the journal Immunological Investigations.

18 Jun 2021

Study finds new clues to explain how Alzheimer’s disease spreads in the brain

Case Western Reserve University researchers studying prions - misfolded proteins that cause lethal incurable diseases - have identified for the first time surface features of human prions responsible for their replication in the brain.

18 Jun 2021

Indian WHO study examines COVID-19 susceptibility in children versus adults

Now, a group of researchers from India have explored this concept due to the lack of solid evidence and have undertaken a community and population-based serosurveillance study for the coronavirus infection under the World Health Organisation (WHO) Unity umbrella. In this study, participants older than two years old were compared to older adults in terms of seropositivity.

17 Jun 2021

Regeneron mAb cocktail benefits hospitalized patients with no natural SARS-CoV-2 antibody response

Researchers reporting on findings from the Randomized Evaluation of COVID-19 Therapy (RECOVERY) trial in the UK are recommending that any therapeutic use of REGEN-COV may be best restricted to individuals without detectable antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

17 Jun 2021

New insight into SARS-CoV-2 mRNA vaccine breakthrough infections

In the current study, vaccine breakthrough infections were noted in 24 people who had previously received COVID-19 vaccines.

17 Jun 2021

Novel ferritin nanoparticle vaccine candidate effective against SARS-CoV-2 variants in preclinical trials

A team of scientists from the United States has recently evaluated the efficacy of a ferritin nanoparticle-formulated, SARS-CoV-2 spike-based vaccine against newly emerged Variants of Concern (VOCs).

17 Jun 2021

Mouse-adapted SARS-CoV-2 and simian adenovirus vector advance COVID-19 vaccine research

A new preprint recently released on the bioRxiv* server describes the immunogenicity and protective potential of a novel adenovirus SARS-CoV-2 vaccine candidate against a form of the virus adapted to cause severe disease in mice. The findings show that this provides a useful mouse model for the study of new vaccines, in addition to demonstrating the protective efficacy of the current rhesus adenovirus vaccine candidate RhAd52.

17 Jun 2021

Not all experts are ready to vaccinate kids against Covid

Lucien Wiggins, 12, arrived at Tufts Children's Hospital by ambulance June 7 with chest pains, dizziness and high levels of a protein in his blood that indicated inflammation of his heart. The symptoms had begun a day earlier, the morning after his second vaccination with the Pfizer-BioNTech mRNA shot.

17 Jun 2021

Aberdeen researchers develop antibody tests to detect new Covid-19 variants

Antibody tests that can detect whether people have been exposed to new variants of Covid-19 have been developed by the University of Aberdeen, in collaboration with biotechnology group Vertebrate Antibodies Ltd and NHS Grampian.

17 Jun 2021

Global blood centers join hands to develop more efficient, accurate blood typing technology

Blood centers from around the world have united to form an international collaboration with academic research institutions and a leading genomic array company, Thermo Fisher Scientific, to deliver a technology which promises to make the future of blood transfusion therapy more efficient, cost-effective, accurate, standardized, and safer.

17 Jun 2021

Antibodies News and Research

RIG-1 agonist shows potent antiviral efficacy against SARS-CoV-2 infection

Combination of interferon-α and nafamostat inhibits SARS-CoV-2 in vivo

COVID-19 outbreak in Mauritius dominated by new SARS-CoV-2 variant B.1.1.318

Could horse-derived antibody therapy be effective against SARS-CoV-2 variants of concern?

First insights into human prion disease could help tackle neurodegenerative diseases

Texas Biomed scientists receive $1 million NIH funding for Ebola research

Previous SARS-CoV-2 infection, vaccines provide protection against gamma variant, study finds

Study examines SARS-CoV-2 replication in cells using super-resolution microscopy

Convalescent plasma can improve chances of survival among blood cancer patients with COVID-19

Combination of anti-HER2 breast cancer therapy and checkpoint inhibitor provides no benefit

The SARS-CoV-2 virus and its vaccines pose unique challenges

Study finds new clues to explain how Alzheimer’s disease spreads in the brain

Indian WHO study examines COVID-19 susceptibility in children versus adults

Regeneron mAb cocktail benefits hospitalized patients with no natural SARS-CoV-2 antibody response

New insight into SARS-CoV-2 mRNA vaccine breakthrough infections

Novel ferritin nanoparticle vaccine candidate effective against SARS-CoV-2 variants in preclinical trials

Mouse-adapted SARS-CoV-2 and simian adenovirus vector advance COVID-19 vaccine research

Not all experts are ready to vaccinate kids against Covid

Aberdeen researchers develop antibody tests to detect new Covid-19 variants

Global blood centers join hands to develop more efficient, accurate blood typing technology

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