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Study shows SARS-CoV-2 prompts NLRP3 inflammasome activation through spike-ACE2 receptor interaction

New research assesses the NLR family pyrin domain containing 3 (NLRP3) inflammasome activation in response to SARS-CoV-2 and its spike protein, and the effects of this exposure in the presence of a-synuclein protein aggregate fibrils.

17 Jan 2022

Efficacy and safety of mRNA-based SARS-CoV-2 vaccination in immuno-compromised subjects

A team of researchers assessed the immune response after administering a SARS-COV-2 vaccine in immuno-compromised subjects who are potentially at an increased risk to experience severe COVID-19 and inadequate response to SARS-CoV2 vaccination.

17 Jan 2022

Study suggests vaccinated Omicron cases are unlikely to shed infectious virus 10 days after diagnosis or symptom onset

Researchers have been investigating the Omicron epidemic in Japan and have recently released an early report on the infectious period of the disease.

17 Jan 2022

Dexamethasone shown to upregulate innate and adaptive immune responses in COVID-19 acute respiratory distress syndrome patients

In a new study, researchers used per protocol bronchoalveolar lavage fluid (BALF) samples after intubation to evaluate the transcriptomic profiles of the local pulmonary host responses during early-stage severe coronavirus disease 2019 (COVID-19) acute respiratory distress syndrome (CARDS), non-COVID-19 ARDS, and sepsis.

17 Jan 2022

Study investigates whether immune responses to BNT162b2 vaccine differ in subjects with and without prior SARS-CoV-2 infection

A new paper published in the journal JCI Insight reports on the differential levels of immunity achieved in those with and without a history of prior infection with the virus following one and two doses of the earliest vaccines to be approved for emergency use.

17 Jan 2022

Study identifies cellular receptors for alphaviruses shared across mosquitoes, humans, and animals

A new study led by researchers at Harvard Medical School has identified a set of cellular receptors for at least three related alphaviruses shared across mosquitoes, humans, and animals that host the virus.

17 Jan 2022

Pathogens turn off mitochondrial defense by hijacking a normal cellular response to stress

Mitochondria are known as energy suppliers for our cells, but they also play an important role in the defense against pathogens. They can initiate immune responses, and deprive pathogens of the nutrients they need to grow.

17 Jan 2022

Mutations in SARS-CoV-2 Omicron variant promote cell binding

Researchers in Germany, based on their recent study published in the journal ChemBioChem, have proposed that the elevated occurrence of positively charged amino acids in specific domains of the severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) Omicron variant spike protein improves viral binding to cellular negatively charged receptors aiding in enhanced infectiousness.

16 Jan 2022

Monitoring rodents for SARS-CoV-2 and other coronaviruses, Hong Kong

A new study published in the Centers for Disease Control and Prevention’s Emerging Infectious Diseases journal has hypothesized that locations with positive SARS-CoV-2 in sewage could be used as potential surveillance targets to analyze if pestiferous urban rodents shed SARS-CoV-2 into the environment.

16 Jan 2022

WHO's recommendation provides two new options for treating COVID-19

WHO has recommended two new drugs for COVID-19, providing yet more options for treating the disease. The extent to which these medicines will save lives depends on how widely available and affordable they will be.

16 Jan 2022

Omicron variant spike protein shows significantly weaker membrane fusion activity than other variants

New research suggests that the SARS-CoV-2 Omicron spike protein requires significantly higher levels of ACE2 for efficient membrane fusion, lagging behind other variants.

14 Jan 2022

Study confirms waning immunity in adolescents following two doses of mRNA COVID-19 vaccines

Researchers test the durability of antibodies produced by a vaccine-induced full-length SARS-CoV-2 spike protein and receptor-binding domain.

13 Jan 2022

Macrophages in the arteries can "sniff" out their surroundings and cause inflammation

An artery is not like a nose. Or is it? Scientists at La Jolla Institute for Immunology (LJI) have discovered that immune cells in arteries can "sniff" out their surroundings and cause inflammation.

13 Jan 2022

UC researchers to examine how stress hormones affect cell degeneration in Parkinson's patients

Stress can have a negative effect on anyone's health but presents particular challenges for people with Parkinson's disease.

13 Jan 2022

Exploring the structural basis of antibody evasion and enhanced transmission of the SARS-CoV-2 Omicron variant

In a new study, researchers used cryogenic electron microscopy (cryo-EM) analysis to capture the open and closed states of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant’s spike protein.

13 Jan 2022

Microbial characteristics of COVID-19

To better understand how the disease progresses, a recent paper in the journal Frontiers in Medicine discusses the role of the human microbiota in this condition.

13 Jan 2022

Analyzing milk produced after maternal COVID-19 diagnosis for the presence of SARS-CoV-2

A recent paper in the journal Frontiers in Immunology describes the demonstration of mucosal antibodies in breast milk that specifically target the virus.

13 Jan 2022

Role of leptin in immune modulation and pathophysiology of COVID-19

A recent review paper in the journal Frontiers in Physiology discusses the role of leptins in infection with SARS-CoV-2 that triggered the ongoing COVID-19 pandemic.

13 Jan 2022

Study finds SARS-CoV-2 infection caused significant changes in the levels of stress associated small RNAs

In this study, researchers described the effect of significant changes of small RNAs in the post-transcriptional regulatory network.

13 Jan 2022

SARS-CoV-2-specific immune responses elicited by inactivated COVID-19 vaccines

In this study, researchers identified and recruited volunteers who received inactivated COVID-19 vaccines in real-world settings.

13 Jan 2022

Receptor News and Research

Study shows SARS-CoV-2 prompts NLRP3 inflammasome activation through spike-ACE2 receptor interaction

Efficacy and safety of mRNA-based SARS-CoV-2 vaccination in immuno-compromised subjects

Study suggests vaccinated Omicron cases are unlikely to shed infectious virus 10 days after diagnosis or symptom onset

Dexamethasone shown to upregulate innate and adaptive immune responses in COVID-19 acute respiratory distress syndrome patients

Study investigates whether immune responses to BNT162b2 vaccine differ in subjects with and without prior SARS-CoV-2 infection

Study identifies cellular receptors for alphaviruses shared across mosquitoes, humans, and animals

Pathogens turn off mitochondrial defense by hijacking a normal cellular response to stress

Mutations in SARS-CoV-2 Omicron variant promote cell binding

Monitoring rodents for SARS-CoV-2 and other coronaviruses, Hong Kong

WHO's recommendation provides two new options for treating COVID-19

Omicron variant spike protein shows significantly weaker membrane fusion activity than other variants

Study confirms waning immunity in adolescents following two doses of mRNA COVID-19 vaccines

Macrophages in the arteries can "sniff" out their surroundings and cause inflammation

UC researchers to examine how stress hormones affect cell degeneration in Parkinson's patients

Exploring the structural basis of antibody evasion and enhanced transmission of the SARS-CoV-2 Omicron variant

Microbial characteristics of COVID-19

Analyzing milk produced after maternal COVID-19 diagnosis for the presence of SARS-CoV-2

Role of leptin in immune modulation and pathophysiology of COVID-19

Study finds SARS-CoV-2 infection caused significant changes in the levels of stress associated small RNAs

SARS-CoV-2-specific immune responses elicited by inactivated COVID-19 vaccines

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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