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Closed Loop Medicine and Pharmanovia commence OptiZest study for their first precision medicine combination therapeutic

Closed Loop Medicine Ltd, a leading TechBio company developing combination prescription drug plus software therapy products that deliver personalized dose optimization, and Pharmanovia, a global pharmaceutical company that commercializes novel medicines and revitalizes, extends and expands the lifecycle of established medicines, today announced the initiation of their OptiZest study, ID: NCT06372470, and first patient recruitment.

From Closed Loop Medicine 16 May 2024

COVID-19 linked to rise in autoimmune lung disease, study finds

A study in eBioMedicine identifies shared immunopathology between SARS-CoV-2 infection and MDA5 autoimmunity, highlighting a surge in MDA5+ cases and interstitial lung disease during the COVID-19 pandemic.

15 May 2024

Menthol-derived molecules: promising candidates for anti-inflammatory and anti-obesity therapy

Modified derivatives of natural products have led to significant therapeutic advances and commercial success in recent times.

15 May 2024

RoboCA3T: A novel robot-inspired computer-assisted adaptive autism therapy

A new study published in the Journal of Computer Assisted Learning introduces a novel Robot-Inspired Computer-Assisted Adaptive Autism Therapy (RoboCA3T) that leverages the natural affinity of children with autism spectrum disorder towards technology and robots.

15 May 2024

Lack of inner voice makes it more difficult to perform verbal memory tasks

The vast majority of people have an ongoing conversation with themselves, an inner voice, that plays an important role in their daily lives.

15 May 2024

New PET imaging biomarker Gal-1 predicts tumor responses to immunotherapy

The protein galectin-1 (Gal-1) has been identified as a new PET imaging biomarker for immune checkpoint blockade (ICB) therapy, allowing physicians to predict the tumor responses before beginning treatment.

15 May 2024

Study proposes a novel therapeutic avenue for tackling EHF-induced cholangiocarcinogenesis

This study is led by Dr. Yiming Luo (Hepatic Surgery Centre, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology) and Professor. Huifang Liang (Hepatic Surgery Centre, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology).

14 May 2024

Researchers find beneficial effects of a novel drug in the management of myocardial infarction

Researchers from the Cardiac Regeneration and Heart Failure Research Group (ICREC) at the Germans Trias i Pujol Research Institute (IGTP) and the Heart Institute of the Germans Trias Hospital(iCor) have found beneficial effects of the novel drug Sacubitril/Valsartan in the management of myocardial infarction (MI).

14 May 2024

Vitrification technique leads to successful birth after ovarian tissue cryopreservation

A woman's egg reserve is finite. Gonad-damaging therapies, such as certain chemotherapies, can therefore lead to infertility. One of the options for preserving fertility is the cryopreservation of ovarian tissue.

14 May 2024

Investigational drug shows promise in increasing oxygen uptake for patients with heart condition

People with a common heart condition were able to use significantly more oxygen while exercising after taking an investigational drug in an international clinical trial, according to a study published today in the New England Journal of Medicine.

14 May 2024

New joint guideline highlights importance of coordinated care for peripheral artery disease

Timely diagnosis and proper management of peripheral artery disease (PAD), including coordinated care from a multispecialty team, are essential to help prevent amputation and other cardiovascular complications and to allow patients with PAD to live longer lives with better physical function and improved quality of life, according to a new joint guideline published today in the American Heart Association's flagship, peer-reviewed journal Circulation and simultaneously in the Journal of the American College of Cardiology.

14 May 2024

Understanding body dysmorphia through WhatsApp profiles of individuals with obesity

New research being presented at the European Congress on Obesity (ECO) in Venice, Italy (12-15 May) has found that many people who are living with obesity conceal their body in their WhatsApp profile pictures.

14 May 2024

Exploring how intense ultrasound can release biological indicators of disease

Ultrasound imaging offers a valuable and noninvasive way to find and monitor cancerous tumors. However, much of the most crucial information about a cancer, such as specific cell types and mutations, cannot be learned from imaging and requires invasive and damaging biopsies.

14 May 2024

What is the ‘immune self,’ and how can this concept benefit immunological research?

A perspective review discusses the concept of the 'immune self' and how adaptive immune responses are influenced by self-similarity. The study emphasizes advances and challenges in defining self-similarity and its impact on immunological research.

13 May 2024

Diet and gut microbiota: how what you eat shapes your gut health

A systematic review published in Gut Microbes found that diet patterns, nutrients, bioactive compounds, and food additives influence gut microbiota. However, the associations were dominated by routinely analyzed nutrients rather than microbiota-relevant nutrients

13 May 2024

Experimental gene therapy shows promise for treating herpes infections

Researchers at Fred Hutch Cancer Center have found in pre-clinical studies that an experimental gene therapy for genital and oral herpes removed 90% or more of the infection and suppressed how much virus can be released from an infected individual, which suggests that the therapy would also reduce the spread of the virus.

13 May 2024

Research explores the effects of nuclear magnetic resonance on internal clock of cells

A research collaboration between the Faculty of Biochemistry and Molecular Medicine at the University of Oulu, Finland, the University of Innsbruck, Austria, and Florida Tech, USA, explored the effects of nuclear magnetic resonance on the internal clock of cells at different times of day and under oxygen deprivation.

13 May 2024

Researchers discover how gut microbes influence social behavior in mice

For people with autism, constipation, diarrhea, and abdominal pain often go along with the social struggles and repetitive behaviors that define the condition.

13 May 2024

Aficamten shows promise in enhancing exercise capacity in patients with hypertrophic cardiomyopathy

Even though mortality and hospitalization rates have improved, the quality of life for those living with hypertrophic cardiomyopathy (HCM) can be compromised with limiting symptoms such as exertional dyspnoea and decreased exercise capacity.

13 May 2024

Semaglutide improves heart failure symptoms and reduces loop diuretic dose

Semaglutide reduces the need for loop diuretic use and dose, and has positive effects on symptoms, physical limitations, and body weight in patients with heart failure with preserved ejection fraction (HFpEF) regardless of diuretic use, according to late breaking research presented today at Heart Failure 2024, a scientific congress of the European Society of Cardiology.

13 May 2024

Therapy News and Research

Closed Loop Medicine and Pharmanovia commence OptiZest study for their first precision medicine combination therapeutic

COVID-19 linked to rise in autoimmune lung disease, study finds

Menthol-derived molecules: promising candidates for anti-inflammatory and anti-obesity therapy

RoboCA3T: A novel robot-inspired computer-assisted adaptive autism therapy

Lack of inner voice makes it more difficult to perform verbal memory tasks

New PET imaging biomarker Gal-1 predicts tumor responses to immunotherapy

Study proposes a novel therapeutic avenue for tackling EHF-induced cholangiocarcinogenesis

Researchers find beneficial effects of a novel drug in the management of myocardial infarction

Vitrification technique leads to successful birth after ovarian tissue cryopreservation

Investigational drug shows promise in increasing oxygen uptake for patients with heart condition

New joint guideline highlights importance of coordinated care for peripheral artery disease

Understanding body dysmorphia through WhatsApp profiles of individuals with obesity

Exploring how intense ultrasound can release biological indicators of disease

What is the ‘immune self,’ and how can this concept benefit immunological research?

Diet and gut microbiota: how what you eat shapes your gut health

Experimental gene therapy shows promise for treating herpes infections

Research explores the effects of nuclear magnetic resonance on internal clock of cells

Researchers discover how gut microbes influence social behavior in mice

Aficamten shows promise in enhancing exercise capacity in patients with hypertrophic cardiomyopathy

Semaglutide improves heart failure symptoms and reduces loop diuretic dose

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