Antigen News and Research

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Dual-signaling CAR T cells show potent anti-cancer activity in animal model

The need to distinguish between normal cells and tumor cells is a feature that has been long sought for most types of cancer drugs.

8 Apr 2013

National Jewish Health researchers unravel mystery of adjuvants

Aluminum salts, or alum, have been injected into billions of people as an adjuvant to make vaccines more effective.

8 Apr 2013

Scientists say detecting single viral protein components challenging for Ebola

By screening a library of a billion llama antibodies on live Ebola viruses in the Texas Biomedical Research Institute's highest biocontainment laboratory, scientists in San Antonio have identified a potential weakness in the make-up of these deadly agents that can immediately yield a sensitive test.

6 Apr 2013

Penn Medicine scientist, trial participant detail experiences on leading edge of gene therapy

Harnessing the patient's own immune system to fight cancer through genetic modification of their own cells is rapidly emerging as a promising treatment option.

6 Apr 2013

Not all mice that come into contact with Borrelia contract Lyme disease, study finds

Like humans, mice can become infected with Borrelia. However, not all mice that come into contact with these bacteria contract the dreaded Lyme disease: Animals with a particular gene variant are immune to the bacteria, as scientists from the universities of Zurich and Lund demonstrate.

5 Apr 2013

AIM suppression could help prevent obesity-associated diseases

Obesity is linked to the widespread epidemics of diabetes and heart disease that plague society, but a lesser-known fact is that the weight can also lead to autoimmune disease.

5 Apr 2013

Antibodies neutralize mosquito-transmitted chikungunya virus, researchers reveal

Researchers have learned the precise structure of the mosquito-transmitted chikungunya virus pathogen while it is bound to antibodies, showing how the infection is likely neutralized.

3 Apr 2013

NewLink Genetics starts Phase 2 clinical study of indoximod in patients with metastatic breast cancer

NewLink Genetics Corporation, a biopharmaceutical company focused on discovering, developing and commercializing cancer therapeutics, today announced the initiation of a double-blind, randomized, placebo-controlled Phase 2 clinical study of its first IDO (indoleamine-(2,3)-dioxygenase) pathway inhibitor, indoximod, in patients with metastatic breast cancer.

2 Apr 2013

Inovio Pharmaceuticals reports release of phase II clinical trial results of ChronVac-C

Inovio Pharmaceuticals, Inc. today announced the release of preliminary clinical trial results by its collaborator ChronTech AS of their open label phase II clinical study of ChronVac-C, ChronTech's vaccine to treat hepatitis C virus infection.

2 Apr 2013

Researchers find no association between receiving too many vaccines too soon and autism

Although scientific evidence suggests that vaccines do not cause autism, approximately one-third of parents continue to express concern that they do; nearly 1 in 10 parents refuse or delay vaccinations because they believe it is safer than following the Centers for Disease Control and Prevention's schedule.

30 Mar 2013

CureVac begins CV9104 Phase 2b clinical trial in patients with castration-resistant prostate cancer

CureVac GmbH, a clinical stage biopharmaceutical company that has pioneered the development of a new class of therapies and vaccines based on messenger RNA, today announced that it has initiated a double-blind, randomized Phase 2b clinical trial of its RNActive cancer vaccine, CV9104, for the treatment of patients with castration-resistant prostate cancer.

28 Mar 2013

Penn researchers develop nanotechnology-inspired technique for diagnosing Lyme disease

Early diagnosis is critical in treating Lyme disease. However, nearly one quarter of Lyme disease patients are initially misdiagnosed because currently available serological tests have poor sensitivity and specificity during the early stages of infection.

27 Mar 2013

Recommendation against routine PSA measurement relies too heavily on randomized trial data

Do the results of recent randomized trials justify the recent U.S. recommendation against yearly measurement of prostate-specific antigen (PSA) as a screening test for prostate cancer? That's the topic of debate in a special "point/counterpoint" section in the April issue of Medical Care.

26 Mar 2013

Novel cell therapy effective in treating aggressive form of childhood leukemia

Two children with an aggressive form of childhood leukemia had a complete remission of their disease—showing no evidence of cancer cells in their bodies—after treatment with a novel cell therapy that reprogrammed their immune cells to rapidly multiply and destroy leukemia cells.

26 Mar 2013

Study of genetically modified immune cells could help improve promising treatment for melanoma

A new study of genetically modified immune cells by scientists from UCLA and the California Institute of Technology could help improve a promising treatment for melanoma, an often fatal form of skin cancer.

24 Mar 2013

By charting differing fates of individual T cells, researchers show unpredictable aspects of immune response

By charting the differing fates of individual T cells, researchers have shown that previously unpredictable aspects of the adaptive immune response can be effectively modeled.

21 Mar 2013

St. Jude Children's Research Hospital receives patent for genetically modified human immune cells for caner therapy

The United States Patent and Trademark Office today awarded St. Jude Children's Research Hospital U.S. patent number 8,399,645 for St. Jude's invention of compositions for genetically modifying human immune cells so they can destroy some of the most common forms of cancer in children and adults.

20 Mar 2013

Protein derived from Pacific cod may inhibit prostate cancer, researchers say

Researchers at the University of Maryland School of Medicine have identified a peptide, or protein, derived from Pacific cod that may inhibit prostate cancer and possibly other cancers from spreading, according to preclinical research published online in the Proceedings of the National Academy of Sciences.

20 Mar 2013

Functional outcomes after radical prostatectomy may vary between surgeons: Study

New evidence from Sweden confirms previous studies which suggest that functional outcomes after radical prostatectomy may vary between surgeons, especially in relation to continence.

20 Mar 2013

Digital rectal exam important for prostate screening, researchers say

The digital rectal exam is an important screening test that can discover prostate cancer that a prostate-specific antigen or PSA test may not, despite the higher sensitivity of the PSA test, according to Penn State College of Medicine researchers.

19 Mar 2013

Antigen News and Research

Dual-signaling CAR T cells show potent anti-cancer activity in animal model

National Jewish Health researchers unravel mystery of adjuvants

Scientists say detecting single viral protein components challenging for Ebola

Penn Medicine scientist, trial participant detail experiences on leading edge of gene therapy

Not all mice that come into contact with Borrelia contract Lyme disease, study finds

AIM suppression could help prevent obesity-associated diseases

Antibodies neutralize mosquito-transmitted chikungunya virus, researchers reveal

NewLink Genetics starts Phase 2 clinical study of indoximod in patients with metastatic breast cancer

Inovio Pharmaceuticals reports release of phase II clinical trial results of ChronVac-C

Researchers find no association between receiving too many vaccines too soon and autism

CureVac begins CV9104 Phase 2b clinical trial in patients with castration-resistant prostate cancer

Penn researchers develop nanotechnology-inspired technique for diagnosing Lyme disease

Recommendation against routine PSA measurement relies too heavily on randomized trial data

Novel cell therapy effective in treating aggressive form of childhood leukemia

Study of genetically modified immune cells could help improve promising treatment for melanoma

By charting differing fates of individual T cells, researchers show unpredictable aspects of immune response

St. Jude Children's Research Hospital receives patent for genetically modified human immune cells for caner therapy

Protein derived from Pacific cod may inhibit prostate cancer, researchers say

Functional outcomes after radical prostatectomy may vary between surgeons: Study

Digital rectal exam important for prostate screening, researchers say

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