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Study highlights poor clinical utility of germline testing in cancer patients of African ancestry

New research in the March 2023 issue of JNCCN - Journal of the National Comprehensive Cancer Network highlights how the lack of genomic research for people with African ancestry, particularly those from the Sub-Saharan region, is hampering efforts to reduce disparities for people with cancer.

10 Mar 2023

Astrocytes play a key role in motor learning

From steering a car to swinging a tennis racket, we learn to execute all kinds of skilled movements during our lives.

10 Mar 2023

Scientists discover how tendons and salivary glands develop in the jaw

A USC-led team of scientists has made a drool-worthy discovery about how tendons and salivary glands develop in the jaw.

10 Mar 2023

Important backup mechanism of human immune cells elucidated

The enzyme TBK1 is an important component of the innate immune system that plays a critical role in the defense against viruses.

10 Mar 2023

Scientists identify the cause of leukemia in people with trisomy 21

People with a third copy of chromosome 21, known as trisomy 21, are at high risk of developing Acute Myeloid Leukaemia (AML), an aggressive form of blood cancer.

10 Mar 2023

Novel triple assortments of swine influenza virus detected in pigs by active surveillance analysis in China

Researchers discuss the results of an active surveillance analysis for the swine influenza virus.

10 Mar 2023

New discoveries made regarding autism onset in mouse models

Although autism is a common neurodevelopmental disorder, the multiple factors behind its onset are still not fully understood.

10 Mar 2023

UVA scientists identify a detox approach to delay aging

University of Virginia scientists have identified a promising approach to delay aging by detoxifying the body of glycerol and glyceraldehyde, harmful by-products of fat that naturally accumulate over time.

9 Mar 2023

New class of oral drugs can inhibit a diverse range of pathogenic SARS-CoV-2 strains

The constant evolution of new COVID-19 variants makes it critical for clinicians to have multiple therapies in their arsenal for treating drug-resistant infections.

9 Mar 2023

Scientists design a model to track hippocampal synaptic plasticity

Scientific evidence shows how the cognitive decline in Alzheimer's disease (AD) is caused by the buildup of amyloid beta proteins, which promote synaptic malfunction.

9 Mar 2023

Individuals with autosomal and X-linked recessive deficiency of IRAK-4 and MyD88 are more susceptible to developing hypoxemic COVID-19 pneumonia

Researchers identified that individuals with a deficiency of myeloid differentiation primary response 88 (MyD88) and interleukin-1 receptor-associated kinase 4 (IRAK-4) due to an autosomal recessive condition were highly susceptible to developing hypoxemic coronavirus disease 2019 (COVID-19) pneumonia when infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

9 Mar 2023

Nasal administration of a fully human anti-CD3 monoclonal antibody modulates T cell inflammatory responses in COVID-19

Researchers assessed the impact of an anti-CD3 monoclonal antibody called Foralumab in COVID-19 treatment.

9 Mar 2023

Scientists discover how excess oxygen changes a handful of proteins in the cells

When it comes to oxygen, you can have too much of a good thing. Breathing air that contains higher levels of oxygen than the usual 21 percent found in Earth's atmosphere can cause organ damage, seizures, and even death in people and animals, particularly if it's in excess of the body's oxygen needs.

8 Mar 2023

Pilot trial tests nasal monoclonal antibody treatment for COVID-19

A pilot trial by investigators from Brigham and Women's Hospital, a founding member of the Mass General Brigham healthcare system, tested the nasal administration of the drug Foralumab, an anti-CD3 monoclonal antibody.

8 Mar 2023

Detection and targeting of splicing deregulation reveal a potential strategy for pAML therapy

Pediatric acute myeloid leukemia or pAML is a childhood blood cancer, one that has proved confounding to clinicians and researchers, with a high relapse rate and relatively few identified genetic mutations (compared to the adult version) that might explain its cause.

8 Mar 2023

Cedars-Sinai study reveals new insights into the effects of hormonal treatment for transgender men

New insights into the effects of a hormonal treatment for transgender men, discovered by Cedars-Sinai investigators, could have implications for the treatment of breast cancer.

8 Mar 2023

Mutant mice models created for studying bipolar disorder

Bipolar disorder (BD) is a debilitating condition characterized by alternating states of depression (known as depressive episodes) and abnormal excitement or irritability (known as manic episodes).

7 Mar 2023

Common scientific method to analyze DNA in early human embryos fails to accurately reflect gene edits

A commonly used scientific method to analyze a tiny amount of DNA in early human embryos fails to accurately reflect gene edits, according to new research led by scientists at Oregon Health & Science University.

7 Mar 2023

The effect of strawberry, blueberry, and strawberry-blueberry blend decoction-based functional beverages on obesity-related metabolic alterations

Researchers evaluated whether polyphenol-rich strawberry and blueberry decoction-based functional beverages could prevent obesity or related metabolic alterations in high-fat and high-fructose diet-fed rats.

7 Mar 2023

Researchers investigate the potential effect of folic acid supplementation on DNA mutation rates

It is well established that folic acid supplementation can significantly reduce the risk of birth defects, including neural tube defects like spina bifida, the most common birth defect of the central nervous system and the second most common of all structural birth defects.

6 Mar 2023

Genes News and Research

Study highlights poor clinical utility of germline testing in cancer patients of African ancestry

Astrocytes play a key role in motor learning

Scientists discover how tendons and salivary glands develop in the jaw

Important backup mechanism of human immune cells elucidated

Scientists identify the cause of leukemia in people with trisomy 21

Novel triple assortments of swine influenza virus detected in pigs by active surveillance analysis in China

New discoveries made regarding autism onset in mouse models

UVA scientists identify a detox approach to delay aging

New class of oral drugs can inhibit a diverse range of pathogenic SARS-CoV-2 strains

Scientists design a model to track hippocampal synaptic plasticity

Individuals with autosomal and X-linked recessive deficiency of IRAK-4 and MyD88 are more susceptible to developing hypoxemic COVID-19 pneumonia

Nasal administration of a fully human anti-CD3 monoclonal antibody modulates T cell inflammatory responses in COVID-19

Scientists discover how excess oxygen changes a handful of proteins in the cells

Pilot trial tests nasal monoclonal antibody treatment for COVID-19

Detection and targeting of splicing deregulation reveal a potential strategy for pAML therapy

Cedars-Sinai study reveals new insights into the effects of hormonal treatment for transgender men

Mutant mice models created for studying bipolar disorder

Common scientific method to analyze DNA in early human embryos fails to accurately reflect gene edits

The effect of strawberry, blueberry, and strawberry-blueberry blend decoction-based functional beverages on obesity-related metabolic alterations

Researchers investigate the potential effect of folic acid supplementation on DNA mutation rates

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