Kidney News and Research

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Johns Hopkins scientists find new compound that may prevent reperfusion injury

In a strategic search, Johns Hopkins scientists created and screened a library of 45,000 new compounds containing chemical elements of widely used immune system suppressants, and say they found one that may prevent reperfusion injury, a tissue-damaging and common complication of surgery, heart attack and stroke.

21 Feb 2019

New screening method could catch organ rejection much earlier without a biopsy needle

Too often, it's only after a transplanted organ has sustained serious damage that a biopsy reveals the organ is in rejection. A new screening method using sensor particles and a urine test could catch rejection much earlier, more comprehensively, and without a biopsy needle.

20 Feb 2019

Study suggests new treatment strategy for deadly brain cancer

In a study of mice and human brain tumors researchers at the University of the Michigan, Ann Arbor, searched for new treatments by exploring the reasons why some patients with gliomas live remarkably longer than others.

19 Feb 2019

Common acid reflux drugs tied to elevated risk for kidney disease

Proton pump inhibitors, which include well-known brand names Prilosec, Nexium and Prevacid, are among the most commonly prescribed medications in the world. Approximately 10 percent of adults in the United States take these drugs for frequent heartburn, acid reflux and gastroesophageal reflux disease.

19 Feb 2019

First molecular test predicts treatment response for kidney cancer

Immunotherapy drugs such as PD-L1 checkpoint inhibitors represent the front-line treatment for kidney cancer. But immunotherapy is expensive, benefits only a subset of patients and is futile in the majority of patients.

19 Feb 2019

Unique gene therapy approach paves new way to tackle rare, inherited diseases

Nonsense mutations are single-letter errors in the genetic code that prematurely halt the production of critical proteins. These unfinished proteins are unable to function normally, and nonsense mutations cause 10-15 percent of all inherited genetic diseases, including Duchenne muscular dystrophy, spinal muscular atrophy, cystic fibrosis and polycystic kidney disease.

19 Feb 2019

Multinational initiative to study familial primary distal renal tubular acidosis

In addition to regulating the body's fluid balance, by excreting greater or smaller amounts of urine, the kidneys also maintain the proper balance of electrolytes (salts) and the pH (an acid-base equilibrium) within our body.

19 Feb 2019

Drug combinations could become first-line treatment for metastatic kidney cancer

A combination of two drugs - one of them an immunotherapy agent - could become a new standard, first-line treatment for patients with metastatic kidney cancer, says an investigator from Dana-Farber Cancer Institute, reporting results from a phase 3 clinical trial.

18 Feb 2019

Conformance of genetic characteristics found to be crucial for longer preservation of kidney graft

The conformance of genetic characteristics is essential for the long-term function after kidney transplantation. This is the central result of a recent study in the top journal “The Lancet” with more than 500 patients after kidney transplantation, conducted by a global consortium led by Rainer Oberbauer and his colleagues Roman Reindl-Schwaighofer and Andreas Heinzel from the Division of Nephrology and Dialysis at MedUni Vienna.

15 Feb 2019

Large-scale clinical trial begins to study liver transplantation between people with HIV

The first large-scale clinical trial to study liver transplantation between people with HIV has begun at clinical centers across the United States. The HOPE in Action Multicenter Liver Study will determine the safety of this practice by evaluating liver recipients for potential transplant-related and HIV-related complications following surgery.

15 Feb 2019

$4.1 million funding for heart research on Valentine's Day

Valentine's Day is a time to celebrate love and romance, but the holiday has also become an opportunity to promote heart health, a tradition that continues as Clemson University bioengineers announce the launch of two separate research projects.

14 Feb 2019

Physiological age is a better predictor of survival than chronological age, shows study

It's often said: It's not how old you are, it's how old you feel. New research shows that physiological age is a better predictor of survival than chronological age. The study is published today in the European Journal of Preventive Cardiology, a journal of the European Society of Cardiology.

14 Feb 2019

Recurring UTIs may mask symptoms of bladder or kidney cancer

Women with bladder or kidney cancer may lose out on a prompt diagnosis if they are already being regularly treated for recurring urinary tract infections (UTIs), according to new research presented at Cancer Research UK's Early Diagnosis Conference in Birmingham today (Wednesday).

13 Feb 2019

Researchers develop powerful new approach to improve maturation of miniature kidneys

In recent years, researchers have created mini-organs known as organoids in the culture dish that contain many of the cell types and complex microarchitectures found in human organs, such as the kidney, liver, intestine, and even the brain.

13 Feb 2019

New mouse model replicates development and progression of Type I diabetes

Researchers at The University of Toledo have found a new way to replicate in lab mice the development and progression of Type I diabetes, a breakthrough that has the potential to reshape how the chronic disease is studied.

13 Feb 2019

Researchers examine link between OSA and inflammation, organ damage

Voyagers no longer embark in search of the storied Fountain of Youth, but the quest for longevity is still very much alive for researchers.

12 Feb 2019

Researchers discover new therapeutic target for rare, aggressive pediatric cancers

Researchers at The University of Texas MD Anderson Cancer Center have discovered that malignant rhabdoid tumors, a rare pediatric cancer without effective treatments, may be sensitive to drugs that block the cancer cell's ability to dispose of misfolded proteins.

12 Feb 2019

Study findings hold promise for children with DMD

Prednisone, the current standard of care used to treat kids with Duchenne muscular dystrophy (DMD), reduces chronic inflammation but has harsh side effects.

11 Feb 2019

Individualized diets more effective in controlling blood glucose levels, study finds

An individualized diet based on a person's genetics, microbiome and lifestyle is more effective in controlling blood glucose (sugar) levels than one that considers only nutritional composition of food, Mayo Clinic researchers have confirmed.

11 Feb 2019

Therapy derived from parasitic worms helps protect against one of chemotherapy's side effects

A therapy derived from the eggs of parasitic worms helps to protect against one of chemotherapy's debilitating side effects by significantly downregulating major proinflammatory pathways and reducing inflammation, indicates the first transcriptome-wide profiling of the bladder during ifosfamide-induced hemorrhagic cystitis.

8 Feb 2019

Kidney News and Research

Johns Hopkins scientists find new compound that may prevent reperfusion injury

New screening method could catch organ rejection much earlier without a biopsy needle

Study suggests new treatment strategy for deadly brain cancer

Common acid reflux drugs tied to elevated risk for kidney disease

First molecular test predicts treatment response for kidney cancer

Unique gene therapy approach paves new way to tackle rare, inherited diseases

Multinational initiative to study familial primary distal renal tubular acidosis

Drug combinations could become first-line treatment for metastatic kidney cancer

Conformance of genetic characteristics found to be crucial for longer preservation of kidney graft

Large-scale clinical trial begins to study liver transplantation between people with HIV

$4.1 million funding for heart research on Valentine's Day

Physiological age is a better predictor of survival than chronological age, shows study

Recurring UTIs may mask symptoms of bladder or kidney cancer

Researchers develop powerful new approach to improve maturation of miniature kidneys

New mouse model replicates development and progression of Type I diabetes

Researchers examine link between OSA and inflammation, organ damage

Researchers discover new therapeutic target for rare, aggressive pediatric cancers

Study findings hold promise for children with DMD

Individualized diets more effective in controlling blood glucose levels, study finds

Therapy derived from parasitic worms helps protect against one of chemotherapy's side effects

Free guide - Everything about renal proximal tubule cells eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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