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Mepolizumab has no hint of added benefit in eosinophilic asthma

The monoclonal antibody mepolizumab has been approved since the end of 2015 for the treatment of adults with severe refractory eosinophilic asthma. The German Institute for Quality and Efficiency in Health Care now examined in an early benefit assessment whether the drug offers an added benefit for patients in comparison with the appropriate comparator therapy.

3 May 2016

New oral cancer drugs getting more expensive over time, study shows

New cancer drugs taken in pill form have become dramatically more expensive in their first year on the market compared with drugs launched 15 years ago, a University of North Carolina at Chapel Hill study has found. The findings call into question the sustainability of a system that sets high prices at market entry in addition to rapidly increasing those prices over time.

30 Apr 2016

Outbreak of tropical parasitic infection observed for first time in the Arctic

An outbreak of an intestinal parasite common in the tropics, known as Cryptosporidium, has been identified for the first time in the Arctic. The discovery was made in Nunavik, Quebec, by a team from the Research Institute of the McGill University Health Centre, in collaboration with the Nunavik Department of Public Health, Institut National de Santé Publique du Québec and Health Canada. The discovery, which was documented in the journal PLoS Neglected Tropical Diseases, could have long-term implications for the health of children in Nunavik and Nunavut's communities.

29 Apr 2016

One-dose of dexamethasone can improve outcomes of asthmatic patients in ER

Adults with asthma who were treated with one-dose dexamethasone in the emergency department had only slightly higher relapse than patients who were treated with a 5-day course of prednisone.

28 Apr 2016

Mozambique women who use modern contraceptives more likely to undergo HIV testing

Women in sub-Saharan Africa who use modern contraceptives are more likely to be tested for HIV than those who do not, according to a study published April 25, 2016 in the open-access journal PLOS ONE by Katherine Center from the University of Arizona and colleagues.

27 Apr 2016

RA patients more likely to experience hearing loss

RA is the commonest autoimmune arthritis affecting 1% of the general population. Despite its main articular manifestations, RA caninvolveextra-articular organs including the auditory system.

25 Apr 2016

WHO outlines steps to close immunization gap across countries during World Immunization Week 2016

During World Immunization Week 2016, held 24-30 April, the World Health Organization highlights recent gains in immunization coverage, and outlines further steps countries can take to “Close the Immunization Gap” and meet global vaccination targets by 2020.

21 Apr 2016

New diagnostic approach may help physicians more efficiently screen for dementia

A tiered diagnostic approach that incorporates clinical, imaging and laboratory data may help physicians more efficiently screen for neurodegenerative disorders such as dementia, according to the consensus of a multi-disciplinary panel of experts.

From Quest Diagnostics 21 Apr 2016

Adding CYP24A1 inhibitors may improve antitumor activity of vitamin D

Roswell Park Cancer Institute research on the most potent form of vitamin D, commonly called calcitriol, offers new insights into approaches that may enhance the antitumor activity of this much-studied human hormone.

20 Apr 2016

Specific oral microbiome linked to pancreatic cancer risk

The presence of certain bacteria in the mouth may reveal increased risk for pancreatic cancer and enable earlier, more precise treatment. This is the main finding of a study led by researchers at NYU Langone Medical Center and its Laura and Isaac Perlmutter Cancer Center to be presented April 19 in New Orleans at the annual meeting of the American Association for Cancer Research.

20 Apr 2016

Nivolumab drug shows survival benefit in phase III trial of patients with head and neck cancer

The immunotherapy drug nivolumab has become the first to show a survival benefit in head and neck cancer, after a major international trial found that it was more effective than standard chemotherapy.

20 Apr 2016

Researchers focus on novel target to treat bacterial infection

Bacterial infection takes hold in the body when a pathogenic microorganism delivers toxins to healthy cells. One way bacteria accomplish this is by releasing vesicles, which act as tiny envelopes transporting toxins and other virulence factors to host cells. These toxins allow the bacteria to "make themselves at home" in cells.

19 Apr 2016

ZIKA virus can be transmitted sexually, confirms Inserm study

A study by researchers from Inserm, the Paris Public Hospitals (Bichat Hospital, AP-HP), Aix-Marseille University, and the National Reference Centre for Arboviruses confirms that the ZIKA virus can be transmitted sexually. Their analyses have shown 100% genetic correlation between the form of the virus present in a man who contracted the virus in Brazil and that of a woman who had never travelled in the epidemic area, but who had sexual relations with him. These results are published in The New England Journal of medicine.

18 Apr 2016

Report highlights parlous state of British children's teeth

The Local Government Association has today published a report that states that around 100 children and teenagers a day are being admitted to hospital for surgery to remove rotten teeth.

18 Apr 2016

New oral blood thinners can decrease stroke risk in atrial fibrillation patients without frequent monitoring

A new generation of blood thinners can reduce the risk of stroke in patients with atrial fibrillation, without requiring frequent monitoring and dietary restrictions.

16 Apr 2016

Heavy marijuana use may lead to lower dopamine release in the brain

In a recent study, researchers found evidence of a compromised dopamine system in heavy users of marijuana. Lower dopamine release was found in the striatum - a region of the brain that is involved in working memory, impulsive behavior, and attention. Previous studies have shown that addiction to other drugs of abuse, such as cocaine and heroin, have similar effects on dopamine release, but such evidence for cannabis was missing until now.

16 Apr 2016

RedHill Biopharma initiates phase II study of BEKINDA for irritable bowel syndrome

RedHill Biopharma Ltd. (NASDAQ; RDHL) (TASE: RDHL) (“RedHill” or the “Company”), a biopharmaceutical company primarily focused on development and commercialization of late clinical-stage, proprietary, orally-administered, small molecule drugs for inflammatory and gastrointestinal diseases, including cancer, today announced that it has initiated a randomized, double-blind, 2-arm parallel group Phase II clinical study in the U.S. evaluating the safety and efficacy of BEKINDA™ 12 mg in patients with diarrhea-predominant irritable bowel syndrome (IBS-D).

13 Apr 2016

Novel antibiotics to overcome antibacterial resistance

Small and innovative pharmaceutical companies, with products in early stages of development, presented some of their novel approaches and antimicrobial therapies under development during a dedicated session at the annual congress (ECCMID) of the European Society of Clinical Microbiology and Infectious Diseases(ESCMID) in Amsterdam.

13 Apr 2016

New plant-derived oral drug can prevent progression of multiple sclerosis

An international research team has demonstrated that a new plant-derived drug can block the progression of multiple sclerosis (MS).

12 Apr 2016

Pooled analysis from seven clinical studies demonstrates consistent efficacy for ceftazidime-avibactam in the treatment of multi-drug resistant gram-negative bacteria

AstraZeneca has presented positive data demonstrating the efficacy of the investigational antibiotic, ceftazidime-avibactam (CAZ-AVI), in treating patients with ceftazidime-resistant Gram-negative infections, which are increasingly resistant to most available antibiotics, often precipitating the need for clinicians to reach for agents previously reserved for last-line use.

12 Apr 2016

Oral News and Research

Mepolizumab has no hint of added benefit in eosinophilic asthma

New oral cancer drugs getting more expensive over time, study shows

Outbreak of tropical parasitic infection observed for first time in the Arctic

One-dose of dexamethasone can improve outcomes of asthmatic patients in ER

Mozambique women who use modern contraceptives more likely to undergo HIV testing

RA patients more likely to experience hearing loss

WHO outlines steps to close immunization gap across countries during World Immunization Week 2016

New diagnostic approach may help physicians more efficiently screen for dementia

Adding CYP24A1 inhibitors may improve antitumor activity of vitamin D

Specific oral microbiome linked to pancreatic cancer risk

Nivolumab drug shows survival benefit in phase III trial of patients with head and neck cancer

Researchers focus on novel target to treat bacterial infection

ZIKA virus can be transmitted sexually, confirms Inserm study

Report highlights parlous state of British children's teeth

New oral blood thinners can decrease stroke risk in atrial fibrillation patients without frequent monitoring

Heavy marijuana use may lead to lower dopamine release in the brain

RedHill Biopharma initiates phase II study of BEKINDA for irritable bowel syndrome

Novel antibiotics to overcome antibacterial resistance

New plant-derived oral drug can prevent progression of multiple sclerosis

Pooled analysis from seven clinical studies demonstrates consistent efficacy for ceftazidime-avibactam in the treatment of multi-drug resistant gram-negative bacteria

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