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Inheriting two genetic mutations that can individually cause epilepsy may cancel each other

Inheriting two genetic mutations that can individually cause epilepsy might actually be "seizure-protective," said Baylor College of Medicine researchers in a report that appears online in the journal Nature Neuroscience.

5 Nov 2007

Endosonography-guided biliary drainage is useful in cases with failed endoscopic biliary stenting

The role of endosonography (ES) in digestive diseases is expanding gradually from diagnostic applications to therapeutic ones. The feasibility of ES-guided cholangiopancreatography was first reported by Harada et al. (pancreatography) and Wiersema et al. (cholangiography) in 1995 and 1996, respectively.

5 Nov 2007

Does neural cell adhesion molecule-180 predict survival in colorectal cancer?

When a person learns they are suffering from cancer, the first question in their mind is always: "How much time do I have?" Unfortunately, this is a question to which the researchers have long been seeking an absolute answer.

5 Nov 2007

Carnegie Mellon researchers to develop new stem cell-based drug delivery therapy

Carnegie Mellon University's Stefan F. Zappe is using adult neural stem cells to develop a new stem cell-based drug delivery therapy that may ultimately help treat a variety of inherited genetic disorders like Hunter syndrome.

5 Nov 2007

Hairpin peptide mimetics show promise as new drugs to fight HIV

When a host cell is infected with HIV, the virus brings its own genetic material into the host cell. This cell then replicates, reads the viral RNA, and uses it as a blueprint to produce more viral proteins.

5 Nov 2007

Antibody might help starve cancerous tumors

An antibody might offer a safe and effective complement to anti-cancer therapies designed to starve malignant tumors by pruning the blood vessels that feed them, researchers report in the November 2 issue of the journal Cell, a publication of Cell Press.

2 Nov 2007

SENP1 protein may provide a basis for future targeted cancer therapies

Researchers at the University of Texas M. D. Anderson Cancer Center have found a protein that enables cellular survival during periods of low oxygen, or hypoxia, which also is key for development of many kinds of cancer.

2 Nov 2007

Studies attribute recent increase in multiple myeloma survival to novel therapies

Multiple myeloma is one of the most common and devastating bone marrow cancers in the U.S., but survival rates have risen dramatically over the past decade.

2 Nov 2007

Regulation of TATA-less promoters

In their upcoming G&D paper, Dr. Robert Tjian (UC Berkeley) and colleagues reveal how histone gene expression is differentially regulated during Drosophila development.

2 Nov 2007

Non-invasive radio waves heat up nanotubes to destroy cancer

Cancer cells treated with carbon nanotubes can be destroyed by non-invasive radio waves that heat up the nanotubes while sparing untreated tissue, a research team led by scientists at The University of Texas M. D. Anderson Cancer Center and Rice University has shown in preclinical experiments.

2 Nov 2007

Enzyme sphingosine kinase 2 show to be potential new target to fight cancer

Researchers at the Virginia Commonwealth University Massey Cancer Center have identified the enzyme sphingosine kinase 2 as a possible new therapeutic target to improve the efficacy of chemotherapy for colon and breast cancer.

2 Nov 2007

Discovery of master switch that regulates blood pressure

A team of Oregon Health & Science University researchers studying a rare form of hypertension has identified the mechanism by which they believe a protein complex in the kidney operates as a master switch that regulates blood pressure, a finding that has broad implications for the treatment of more common forms of hypertension.

2 Nov 2007

Discovery of novel mechanism to predict survival in older women with early stage lung cancer

A novel mechanism to predict survival in older women with early stage lung cancer has been uncoverecd by researchers at UCLA's Jonsson Comprehensive Cancer Center, a discovery that may have significant implications for new treatment approaches.

2 Nov 2007

Researchers find stem cells in degenerating spinal discs, potential for repair

Orthopedic researchers at Jefferson Medical College have for the first time found stem cells in the intervertebral discs of the human spine, suggesting that such cells might someday be used to help repair degenerating discs and remedy lower back and neck pain.

2 Nov 2007

Immune cell age plays role in retinal damage in age-related macular degeneration

Studying a mouse model of age-related macular degeneration, the leading cause of blindness in older Americans, scientists at Washington University School of Medicine in St. Louis have found age is key in determining whether damaging blood vessels will form beneath the retina and contribute to vision loss.

2 Nov 2007