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New molecules discovered that block cancer cells from modifying cell DNA

Researchers have discovered new small molecules that may prevent prostate cancer cells from turning off normal genes in a process that transforms normal cells into cancer cells. This significant discovery in the field of epigenetics has immediate implications in the development of new diagnostic tests and cancer medications.

12 Oct 2007

Gene SIRT1 could lead to new cholesterol strategies

MIT researchers have discovered a link between a gene believed to promote long lifespan and a pathway that flushes cholesterol from the body. The finding could help researchers create drugs that lower the risk of diseases associated with high cholesterol, including atherosclerosis (clogged arteries) and Alzheimer's disease.

12 Oct 2007

A tumor-blocking protein may be key in developing deadly form of pancreatic cancer

A tumor-blocking protein previously implicated in prostate and breast cancer development may also be behind the most aggressive type of pancreatic cancer. Researchers at the Kimmel Cancer Center at Jefferson in Philadelphia have discovered that the protein pp32 – which normally applies the brakes on a cancer-causing gene – is missing in an aggressive form of pancreatic cancer.

12 Oct 2007

Genome update defines landscape of breast and colon cancers

One year after completing the first large-scale report sequencing breast and colon cancer genes, Johns Hopkins Kimmel Cancer Center scientists have studied the vast majority of protein-coding genes which now suggest a landscape dominated by genes that each are mutated in relatively few cancers.

12 Oct 2007

Anticlotting drug found to be safe in sickle cell patients

An intravenous "blood thinner" widely used in patients with acute coronary syndromes and during coronary artery stent placement appears to be safe in patients with sickle cell disease and may have beneficial anti-inflammatory effects, a small study at the University of North Carolina at Chapel Hill School of Medicine has found.

12 Oct 2007

A fresh perspective to the study of cell activity

In process that is shrouded in mystery, rod-shaped bacteria reproduce by splitting themselves in two. By applying advanced mathematics to laboratory data, a team led by Johns Hopkins researchers has solved a small but important part of this reproductive puzzle.

12 Oct 2007

Cancer researchers investigate free radicals

The University of Leicester has been selected as the hub of a worldwide network of researchers to investigate one of the causes of cancer.

11 Oct 2007

Scientists answer century-old developmental question

Embryologists at UCL (University College London) have helped solve an evolutionary riddle that has been puzzling scientists for over a century.

11 Oct 2007

Research shows how stem cells decide to become either skeletal or smooth muscle

Researchers have discovered a key protein that controls how stem cells "choose" to become either skeletal muscle cells that move limbs, or smooth muscle cells that support blood vessels, according to a study published in the Proceedings of the National Academy of Sciences (PNAS).

11 Oct 2007

New understanding of stem cell aging

The Stowers Institute's Xie Lab has published recent findings that reveal some of the factors underlying the aging of stem cells.

11 Oct 2007

Researchers reveal repressor protein blocks neural stem cell development

A protein known to repress gene transcription at the molecular level in a variety of processes also blocks embryonic neural stem cells from differentiating into neurons, according to a study by University of California, San Diego and Howard Hughes Medical Institute (HHMI) researchers published online October 10 in Nature.

10 Oct 2007

Study unravels some of the mystery surrounding the devastating 1918 pandemic

Often called the most devastating epidemic in the recorded history of the world, the 1918 influenza virus pandemic was responsible for more than 40 million deaths across the globe.

10 Oct 2007

Rare bone marrow transplant procedure as University of California, San Diego Medical Center

Patients living with Myasthenia Gravis (MG) may breathe easier thanks to a rare bone marrow transplant procedure performed at The Bone Marrow Transplant Program at University of California, San Diego Medical Center, the only program in the western United States that has attempted this procedure.

10 Oct 2007

Obese people six times more likely to develop oesophageal cancer

Rates of oesophageal cancer have been rising rapidly, and in some countries, they have risen faster than those of every other major cancer, say the authors.

10 Oct 2007

Better understanding of environmental influences on the aging process of stem cells

A stem cells' immediate neighborhood, a specialized environment also known as the stem cell niche, provides crucial support needed for stem cell maintenance.

10 Oct 2007

Mouse mammary tumor virus might be involved in causing human breast cancer

Mouse mammary tumor virus (MMTV) - which causes mammary cancer in mice - can replicate and spread in human cells, research published this week shows.

10 Oct 2007

Feline virus, antiviral drug studied to understand drug resistance

Researchers at Ohio State will spend the next two years testing their theories about just how an AIDS-like virus in cats is able to resist the powerful medicines that are thrown against it.

10 Oct 2007

Bacteria reveal targets of immune responses quick and direct identification of antigens

The Epstein-Barr virus (EBV) is a widespread herpes virus that infects more than 90 per cent of the worldwide human population.

10 Oct 2007

Adult stem cells lack key pluripotency regulator

The protein Oct4 plays a major role in embryonic stem cells, acting as a master regulator of the genes that keep the cells in an undifferentiated state.

10 Oct 2007

Network approach finds potential breast cancer susceptibility gene

Like a crossword-puzzle solver who uses the letters in some answers to figure out others, researchers at Dana-Farber Cancer Institute and an international group of collaborators have used data on genes involved in inherited forms of breast cancer to identify a gene linked to non-hereditary cases of the disease.

10 Oct 2007