Immunodeficiency News and Research

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Immunodeficiency (or immune deficiency) is a state in which the immune system's ability to fight infectious disease is compromised or entirely absent.

Algal metabolites as novel drugs against viruses

A new review article published in the Journal of Biotechnology has provided information on various nutraceutical metabolites extracted from algae.

29 Mar 2022

Breast milk components show potent in vitro SARS-CoV-2 inhibition

Human breastmilk contains substances that can inhibit infection by SARS-CoV-2 and its variants, as well as prevent its replication.

24 Mar 2022

CD63-expressing extracellular vesicles neutralize SARS-CoV-2 variants of concern

Researchers evaluate antiviral effects of CD63 tetraspanin extracellular vesicles against SARS-CoV-2 and HIV-1.

22 Mar 2022

The importance of the endosomal pathway for SARS-CoV-2 entry

Researchers demonstrated that combined inhibition of cell-surface-based and endosomal pathways completely blocked SARS-CoV-2 entry into mammalian cells.

21 Mar 2022

Presence of zoonotic pathogens in wildlife market for human consumption in Laos

Researchers from different countries examined various animal species from wildlife trade sites to detect the presence of zoonotic pathogens in Laos, South East Asia.

18 Mar 2022

SARS-CoV-2 burden and transmission in one rural and one urban community in South Africa

Researchers conducted a prospective household cohort study of COVID-19, influenza, and respiratory syncytial virus community burden, viral interaction, and transmission dynamics, called PHIRST-C study in South Africa.

18 Mar 2022

Study finds high rates of cancer among men living with HIV

Researchers with Case Western Reserve University have found that there are nearly twice as many men with cancer among men living with HIV (MLWH) compared to men who do not have the human immunodeficiency virus.

17 Mar 2022

Novel fusion inhibitor blocks SARS-CoV-2 spike-mediated cell-cell fusion

Researchers constructed a novel fusion inhibitor−based recombinant protein, referred to as 5−Helix, to block SARS-CoV-2 spike-mediated cell-cell fusion.

17 Mar 2022

The immunogenicity of homologous and heterologous boosters in adults who received inactivated COVID-19 vaccine six months prior

Researchers compared the efficacy of booster doses of heterologous intramuscular and aerosolized adenovirus-vectored vaccine, a recombinant protein-based ZF2001 vaccine, and homologous CoronaVac vaccines.

17 Mar 2022

Bioactive small molecules enhance CRISPR/Cas9 loss-of-function editing in human cells

Researchers demonstrate enhanced loss-of-function editing of CRISPR/Cas9 in human cells.

14 Mar 2022

Study reveals new insights on how immune system cells respond to disease-causing pathogens

In laboratory experiments involving a class of mutations in people with a rare collection of immune system disorders, Johns Hopkins Medicine researchers say they have uncovered new details about how immune system cells respond to disease-causing bacteria, fungi and viruses such as SARS-CoV-2.

8 Mar 2022

Relationship between immunological responses in the acute phase of SARS-CoV-2 infection and long-term cognitive deficits

A recent study reported that monocytosis during the acute phase of coronavirus disease 2019 could forecast anosognosia in long COVID.

8 Mar 2022

Potential of a SARS-CoV-2 immunoPET approach to study COVID-19 dynamics in total body in rhesus macaques

In a recent study an immunoPET technique that the authors were using to analyze SIV was adapted to evaluate the spatiotemporal dynamics of SARS-CoV-2 infection in a rhesus macaque model.

2 Mar 2022

Understanding the evolutionary mutational patterns of chronic SARS-CoV-2 infection

In a new study, researchers elucidated the factors driving adaptive evolution in chronic SARS-CoV-2 infections.

2 Mar 2022

Peptide-based vaccine fails to protect mice against SARS-CoV-2 despite T cell response

A recent study observed that peptide-based vaccination against SARS-CoV-2 failed to protect mice against COVID-19, albeit eliciting T cell responses.

28 Feb 2022

A regional corner of Africa found to be a hotspot for highly infectious diseases

A regional corner of Africa is a hotspot for cases of HIV, tuberculosis and malaria, prompting researchers to call for targeted health support rather than a national response.

25 Feb 2022

Immunomolecular detection method to rapidly and accurately detect complete SARS-CoV-2 virions

Researchers developed a hybrid assay incorporating immunological antibody-based viral spike protein capture with molecular nucleic acid amplification by qRT-PCR.

24 Feb 2022

Neanderthal gene makes people susceptible to COVID-19, but protects against HIV

A study recently published in the top-tier journal Proceedings of the National Academy of Sciences of the United States of America (PNAS) shows how a specific gene flow from Neandertals can act as a double-edged sword by increasing the risk for the development of severe coronavirus disease 2019 (COVID-19), and at the same time decreasing the risk for the infection with the human immunodeficiency virus (HIV).

23 Feb 2022

Climate change is sickening, literally!

A news study highlights the change in disease spread with climate change across the globe.

21 Feb 2022

Emergence of new HIV variant underscores importance of monitoring virus mutations

A new study published in the journal Science reported the presence of a subtype-B variant of HIV-1 with remarkably high virulence, circulating in the Netherlands during the past two decades.

20 Feb 2022

Immunodeficiency News and Research

Further Reading

Algal metabolites as novel drugs against viruses

Breast milk components show potent in vitro SARS-CoV-2 inhibition

CD63-expressing extracellular vesicles neutralize SARS-CoV-2 variants of concern

The importance of the endosomal pathway for SARS-CoV-2 entry

Presence of zoonotic pathogens in wildlife market for human consumption in Laos

SARS-CoV-2 burden and transmission in one rural and one urban community in South Africa

Study finds high rates of cancer among men living with HIV

Novel fusion inhibitor blocks SARS-CoV-2 spike-mediated cell-cell fusion

The immunogenicity of homologous and heterologous boosters in adults who received inactivated COVID-19 vaccine six months prior

Bioactive small molecules enhance CRISPR/Cas9 loss-of-function editing in human cells

Study reveals new insights on how immune system cells respond to disease-causing pathogens

Relationship between immunological responses in the acute phase of SARS-CoV-2 infection and long-term cognitive deficits

Potential of a SARS-CoV-2 immunoPET approach to study COVID-19 dynamics in total body in rhesus macaques

Understanding the evolutionary mutational patterns of chronic SARS-CoV-2 infection

Peptide-based vaccine fails to protect mice against SARS-CoV-2 despite T cell response

A regional corner of Africa found to be a hotspot for highly infectious diseases

Immunomolecular detection method to rapidly and accurately detect complete SARS-CoV-2 virions

Neanderthal gene makes people susceptible to COVID-19, but protects against HIV

Climate change is sickening, literally!

Emergence of new HIV variant underscores importance of monitoring virus mutations

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