Immunodeficiency News and Research

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Immunodeficiency (or immune deficiency) is a state in which the immune system's ability to fight infectious disease is compromised or entirely absent.

The effect of unsuppressed HIV on T-cell response to COVID-19

A new study evaluates the impact of HIV infection on SARS-CoV-2 T-cell responses during the first and second waves of COVID-19 in South Africa.

10 Apr 2022

Improved seroprevalence and antibody response after third COVID-19 vaccination

Researchers evaluated the immunogenicity of a third COVID-19 vaccination in antibody deficient subjects.

8 Apr 2022

Key protein could be a novel target for treatment of patients with B cell signaling deficiencies

The rules to the kids' game "red light, green light" are easy to follow: red always means stop, and green always means go. But now, researchers from Japan have found that a key protein involved in B cell signaling acts as both a red light to signaling in healthy cells and a green light to signaling in immune-deficient cells.

4 Apr 2022

SARS-CoV-2 prevalence during the initial period of SARS-CoV-2 Omicron variant emergence in Finland

A recent study presented the rapid spike in COVID-19 seroprevalence during the emergence of the Omicron variant in Finland.

4 Apr 2022

Acute respiratory distress syndrome may increase death risk among young COVID-19 patients

A new study estimated the risk and prevalence of acute respiratory distress syndrome in hospitalized young adults with SARS-CoV-2 infection.

4 Apr 2022

mRNA-1273 and BNT162b2 COVID-19 vaccines induce slightly different immune responses

In a recent study published in the journal Science, researchers observed differential effector functions of antibodies elicited by Pfizer’s BNT162b2 and Moderna’s messenger ribonucleic acid (mRNA)-1273 coronavirus disease 2019 (COVID-19) vaccines.

4 Apr 2022

Scientists use new CRISPR gene-editing approach to find paths toward possible HIV cure

Scientists at Northwestern Medicine are using new advances in CRISPR gene-editing technology to uncover new biology that could lead to longer-lasting treatments and new therapeutic strategies for Human Immunodeficiency Virus (HIV).

1 Apr 2022

Research illuminates why immune disorders affect only one of two identical twins

Scientists have long queried the causes of immune disorders in only one of two identical twins with identical genes. New research from the Wellcome Sanger Institute, the Josep Carreras Leukaemia Research Institute in Spain and their collaborators, has found the answer lies in both alterations in immune cell-cell communication and the epigenome, the host of biological processes that regulate how our genes function.

1 Apr 2022

Clinical trials for experimental HIV vaccines based on mRNA technology begin in United States

Scientists urge African leaders to demand fair licensing following clinical trials of an HIV vaccine candidate.

30 Mar 2022

Study shows that the SARS-CoV-2 envelope protein potently restricts HIV-1 infection

Researchers demonstrated that E proteins of β-coronaviruses could restrict HIV-1 infection.

30 Mar 2022

Furin inhibitors as potential therapies to combat SARS-CoV-2 and other diseases

Furin inhibitors as potential therapeutics for treating COVID-19 and other diseases, wherein furin is integral for their pathogenicity and progression.

29 Mar 2022

Penn researchers generate functional CAR T cells with enhanced anti-tumor potency in 24 hours

A new approach from Penn Medicine researchers could cut the time it takes to alter patients' immune cells for infusion back into the body to find and attack cancer.

29 Mar 2022

Algal metabolites as novel drugs against viruses

A new review article published in the Journal of Biotechnology has provided information on various nutraceutical metabolites extracted from algae.

29 Mar 2022

Breast milk components show potent in vitro SARS-CoV-2 inhibition

Human breastmilk contains substances that can inhibit infection by SARS-CoV-2 and its variants, as well as prevent its replication.

24 Mar 2022

CD63-expressing extracellular vesicles neutralize SARS-CoV-2 variants of concern

Researchers evaluate antiviral effects of CD63 tetraspanin extracellular vesicles against SARS-CoV-2 and HIV-1.

22 Mar 2022

The importance of the endosomal pathway for SARS-CoV-2 entry

Researchers demonstrated that combined inhibition of cell-surface-based and endosomal pathways completely blocked SARS-CoV-2 entry into mammalian cells.

21 Mar 2022

Presence of zoonotic pathogens in wildlife market for human consumption in Laos

Researchers from different countries examined various animal species from wildlife trade sites to detect the presence of zoonotic pathogens in Laos, South East Asia.

18 Mar 2022

SARS-CoV-2 burden and transmission in one rural and one urban community in South Africa

Researchers conducted a prospective household cohort study of COVID-19, influenza, and respiratory syncytial virus community burden, viral interaction, and transmission dynamics, called PHIRST-C study in South Africa.

18 Mar 2022

Study finds high rates of cancer among men living with HIV

Researchers with Case Western Reserve University have found that there are nearly twice as many men with cancer among men living with HIV (MLWH) compared to men who do not have the human immunodeficiency virus.

17 Mar 2022

Novel fusion inhibitor blocks SARS-CoV-2 spike-mediated cell-cell fusion

Researchers constructed a novel fusion inhibitor−based recombinant protein, referred to as 5−Helix, to block SARS-CoV-2 spike-mediated cell-cell fusion.

17 Mar 2022

Immunodeficiency News and Research

Further Reading

The effect of unsuppressed HIV on T-cell response to COVID-19

Improved seroprevalence and antibody response after third COVID-19 vaccination

Key protein could be a novel target for treatment of patients with B cell signaling deficiencies

SARS-CoV-2 prevalence during the initial period of SARS-CoV-2 Omicron variant emergence in Finland

Acute respiratory distress syndrome may increase death risk among young COVID-19 patients

mRNA-1273 and BNT162b2 COVID-19 vaccines induce slightly different immune responses

Scientists use new CRISPR gene-editing approach to find paths toward possible HIV cure

Research illuminates why immune disorders affect only one of two identical twins

Clinical trials for experimental HIV vaccines based on mRNA technology begin in United States

Study shows that the SARS-CoV-2 envelope protein potently restricts HIV-1 infection

Furin inhibitors as potential therapies to combat SARS-CoV-2 and other diseases

Penn researchers generate functional CAR T cells with enhanced anti-tumor potency in 24 hours

Algal metabolites as novel drugs against viruses

Breast milk components show potent in vitro SARS-CoV-2 inhibition

CD63-expressing extracellular vesicles neutralize SARS-CoV-2 variants of concern

The importance of the endosomal pathway for SARS-CoV-2 entry

Presence of zoonotic pathogens in wildlife market for human consumption in Laos

SARS-CoV-2 burden and transmission in one rural and one urban community in South Africa

Study finds high rates of cancer among men living with HIV

Novel fusion inhibitor blocks SARS-CoV-2 spike-mediated cell-cell fusion

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

The impact of vibration on microscopy

How Omics Technologies Are Transforming Biological Research and Drug Discovery

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