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Harnessing intestinal microbes to combat inflammation and infections

Despite being an everyday necessity, nutrition is something of a black box. We know that many plant-based foods are good for us, but we don't always know why.

27 Mar 2025

Transforming genetic deafness treatment with base editing

Congenital hearing loss refers to impaired auditory function that occurs due to genetic causes. GJB2 is the gene responsible for approximately half of all cases of hereditary hearing loss.

27 Mar 2025

Arthritis drug shows promise in halting seizures in mice with epilepsy

A drug typically prescribed for arthritis halts brain-damaging seizures in mice that have a condition like epilepsy, according to researchers at the University of Wisconsin–Madison.

25 Mar 2025

Cryptotanshinone could be a promising therapeutic option for Kawasaki disease

Announcing a new publication for Acta Materia Medica journal. Kawasaki disease (KD) is a form of vasculitis that affects primarily children and can lead to severe cardiovascular complications.

25 Mar 2025

Natural product derivative demonstrates promising therapeutic potential for psoriasis

Announcing a new publication for Acta Materia Medica journal. Phosphodiesterase-4 (PDE4), a member of the phosphodiesterase superfamily, has highly important roles in cyclic nucleotide signaling pathways and a variety of skin disorders.

25 Mar 2025

New brain circuit involved in motion sickness could help improve metabolic health

Motion sickness is a very common condition that affects about 1 in 3 people, but the brain circuits involved are largely unknown. In the current study published in Nature Metabolism, researchers at Baylor College of Medicine, the University of Texas Health Science Center at Houston and the Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital describe a new brain circuit involved in motion sickness that also contributes to regulating body temperature and metabolic balance.

24 Mar 2025

Mount Sinai-led research uncovers mechanisms behind Crohn's disease inflammation

A research team led by Mount Sinai has uncovered mechanisms of abnormal immune cell function that may lead to Crohn's disease, according to findings published in Science Immunology on March 21.

22 Mar 2025

Study offers new insights into the harmful effects of sugar-sweetened beverages on human health

Researchers at the Advanced Research Unit on Metabolism, Development & Aging (ARUMDA), in the Tata Institute of Fundamental Research (TIFR, Mumbai and TIFR Hyderabad), have unveiled a comprehensive understanding of the harmful effects of sugar-sweetened beverages (SSBs) on human health, using a preclinical mouse model that closely mimics human consumption patterns.

21 Mar 2025

Eye drops show potential to slow progression of human degenerative retinal diseases

Treatment shows potential to slow the progression of human degenerative eye diseases, including retinitis pigmentosa.

21 Mar 2025

Uniquely-shaped magnetic nanoparticles offer breakthrough in cancer therapy

New magnetic nanoparticles in the shape of a cube sandwiched between two pyramids represent a breakthrough for treating ovarian tumors and possibly other types of cancer, according to the Oregon State University researchers who developed them.

19 Mar 2025

UCLA Health discovers drug that mimics stroke rehabilitation effects in mice

A new study by UCLA Health has discovered what researchers say is the first drug to fully reproduce the effects of physical stroke rehabilitation in model mice, following from human studies.

19 Mar 2025

$1 million CPRIT grant focuses on AI to improve prostate cancer outcomes

Erzsébet Merényi, a statistics research professor at Rice University, and co-investigators at The University of Texas MD Anderson Cancer Center Pratip Bhattacharya, professor of cancer systems imaging, and Dr. Patrick Pilié, assistant professor of genitourinary medical oncology, were awarded $1 million by the Cancer Prevention and Research Institute of Texas (CPRIT) to develop artificial intelligence (AI) tools that can identify lethal forms of prostate cancer earlier and improve treatment selection.

18 Mar 2025

Testing a novel approach to restore normal heart function in Myotonic Dystrophy Type 1

Myotonic Dystrophy Type 1 (DM1) is the most common adult-onset form of muscular dystrophy and a condition that severely affects multiple organs including skeletal muscle, heart, brain and the gastrointestinal tract.

18 Mar 2025

Current antivirals not successful in treating severe H5N1 bird flu infections

As the H5N1 avian influenza outbreak continues, scientists are working to better understand the virus's threat to human health.

17 Mar 2025

Semi-synthetic bile acid could be a promising therapeutic option for TH17-mediated intestinal diseases

A research team from the Medical University of Vienna has made further progress in the treatment of intestinal inflammation.

14 Mar 2025

NIH researchers define topical steroid withdrawal diagnostic criteria

Researchers at the National Institutes of Health (NIH) have determined that dermatitis resulting from topical steroid withdrawal (TSW) is distinct from eczema and is caused by an excess of an essential chemical compound in the body.

14 Mar 2025

New research aims to unravel genetic mysteries of polycystic kidney disease

Polycystic kidney disease (PKD), a family of genetic disorders that causes clusters of cysts to form on the kidney, is among the most common genetic disorders, affecting some 500,000 people in the United States.

14 Mar 2025

Targeted alpha therapy offers new hope for treating metastatic melanoma

Metastatic melanoma, also known as stage IV melanoma, is a type of skin cancer that spreads to other parts of the body.

12 Mar 2025

Natural ingredient gluconolactone offers hope for targeted lupus therapy

Lupus is an autoimmune disease where the body’s immune system attacks its own tissues and organs, causing inflammation and damaging organs.

12 Mar 2025

Compound found in rosemary shows promise for Alzheimer's treatment

The herb rosemary has long been linked with memory: "There's rosemary, that's for remembrance," says Ophelia in Shakespeare's Hamlet. So it is fitting that researchers would study a compound found in rosemary and sage-carnosic acid-for its impact on Alzheimer's disease.

10 Mar 2025

Mouse Model News and Research

Harnessing intestinal microbes to combat inflammation and infections

Transforming genetic deafness treatment with base editing

Arthritis drug shows promise in halting seizures in mice with epilepsy

Cryptotanshinone could be a promising therapeutic option for Kawasaki disease

Natural product derivative demonstrates promising therapeutic potential for psoriasis

New brain circuit involved in motion sickness could help improve metabolic health

Mount Sinai-led research uncovers mechanisms behind Crohn's disease inflammation

Study offers new insights into the harmful effects of sugar-sweetened beverages on human health

Eye drops show potential to slow progression of human degenerative retinal diseases

Uniquely-shaped magnetic nanoparticles offer breakthrough in cancer therapy

UCLA Health discovers drug that mimics stroke rehabilitation effects in mice

$1 million CPRIT grant focuses on AI to improve prostate cancer outcomes

Testing a novel approach to restore normal heart function in Myotonic Dystrophy Type 1

Current antivirals not successful in treating severe H5N1 bird flu infections

Semi-synthetic bile acid could be a promising therapeutic option for TH17-mediated intestinal diseases

NIH researchers define topical steroid withdrawal diagnostic criteria

New research aims to unravel genetic mysteries of polycystic kidney disease

Targeted alpha therapy offers new hope for treating metastatic melanoma

Natural ingredient gluconolactone offers hope for targeted lupus therapy

Compound found in rosemary shows promise for Alzheimer's treatment

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