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Researchers identify genomic regions linked to ulcerative colitis in African-Americans

In the first genome-wide association study of genetic risk factors for inflammatory bowel disease in African Americans, a research team has identified two regions of the genome (loci) associated with ulcerative colitis only in people of African descent.

20 Oct 2016

Gene variants linked to hot flashes in menopausal women

Most women experience hot flashes and night sweats either before or during menopause, but a significant minority don't have these symptoms. Could our genes be a factor in determining which women get hot flashes?

19 Oct 2016

Study offers promise for therapeutic management of fetal and congenital genetic diseases in utero

A breakthrough study by research teams at Rosalind Franklin University of Medicine and Science and Oregon Health & Science University offers promise for therapeutic management of congenital diseases in utero using designer nucleotide sequences that can simply be injected into the fluid surrounding the developing fetus to potentially treat disabling-to-lethal genetic defects.

7 Oct 2016

TUM scientists develop bioinformatics tool that allows worldwide bacterial analysis

Sequencing data from biological samples such as the skin, intestinal tissues, or soil and water are usually archived in public databases.

6 Oct 2016

New TSRI study offers surprising twist on how life began on Earth

A new study led by scientists at The Scripps Research Institute (TSRI) offers a twist on a popular theory for how life on Earth began about four billion years ago.

30 Sep 2016

Study finds no link between milk intake and cardiovascular risk

Researchers in Valencia participated in an international study that has debunked the association between milk and dairy products and increased cardiovascular risk.

29 Sep 2016

Synthego introduces CRISPRevolution synthetic sgRNA kit for fast, high-throughput gene editing

Synthego, a leading provider of genome engineering solutions, today announces the world’s first synthetic single guide RNA (sgRNA) CRISPR genome editing kit.

24 Sep 2016

New global health strategy aims to eliminate HCV as global public health threat by 2030

Chronic infection by the hepatitis C virus (HCV) proved fatal for over 700,000 people worldwide in 2013, mainly as a result of liver damage. Although information on the epidemiology of transmission and infection is sparse, recent estimates put the global prevalence of HCV infection at 130-150 million people.

21 Sep 2016

Study suggests interactions between distant DNA regions may impact disease gene levels

A person's DNA sequence can provide a lot of information about how genes are turned on and off, but new research out of Case Western Reserve University School of Medicine suggests the 3-D structure DNA forms as it crams into cells may provide an additional layer of gene control.

21 Sep 2016

Penn researchers develop open-source software to infer evolutionary track of tumor metastasis

Individual cells within a tumor are not all the same. This may sound like a modern medical truism, but it wasn't very long ago that oncologists assumed that taking a single biopsy from a patient's tumor would be an accurate reflection of the physiological and genetic make-up of the entire mass.

9 Sep 2016

Research offers new insights into underlying mechanisms of deadly cystic fibrosis

A minor hiccup in the sequence of a human gene can have devastating impacts on health. Such flaws cause cystic fibrosis (CF), a disease affecting the lungs and other vital organs, often leading to death by the age of 30.

9 Sep 2016

MIT biologists unravel lncRNA structure-to-function relationships

Several years ago, biologists discovered a new type of genetic material known as long noncoding RNA. This RNA does not code for proteins and is copied from sections of the genome once believed to be "junk DNA."

9 Sep 2016

Researchers identify potential new way of treating hypertension

Researchers eyeing first new anti-hypertensive drug treatment strategy in more than 15 years.

6 Sep 2016

Study reveals vital new details about inner workings of CRISPR-Cas9 machinery in live cells

A study in The Journal of Cell Biology by scientists at the University of Massachusetts Medical School reveals important new details about the inner workings of the CRISPR-Cas9 machinery in live cells that may have implications for the development of therapeutics that use the powerful gene editing tool.

30 Aug 2016

Preimplantation genetic screening using next generation sequencing: an interview with Dr Luis Alcaraz

PGS, Preimplantation Genetic Screening, is a genetic test that analyses biopsied cells from embryos produced by in vitro fertilization (IVF) techniques. PGS determines whether the embryos are chromosomally normal (euploid) or not (aneuploid), thus giving the chance to transfer chromosomally normal embryos that are more apt to successfully implant and develop into a pregnancy.

24 Aug 2016

Researchers design DNA-based circuit that does math in a test tube

Often described as the blueprint of life, DNA contains the instructions for making every living thing from a human to a house fly.

24 Aug 2016

Penn scientists develop combined medical and surgical care plan for managing Crohn's disease

The first published combined medical and surgical care plan for managing septic perianal Crohn's disease, a serious complication that occurs in around 40 percent of Crohn's disease patients, has been developed by researchers at Penn State College of Medicine.

23 Aug 2016

Cloned Zika virus could be used for development of attenuated vaccine

Stopping the explosive spread of Zika virus - which can lead to birth defects in babies born to infected mothers - depends on genetic insights gleaned through new tools and models.

23 Aug 2016

Neuroscientists demonstrate revolutionary new way of mapping the brain at single-neuron resolution

Neuroscientists today publish in Neuron details of a revolutionary new way of mapping the brain at the resolution of individual neurons, which they have successfully demonstrated in the mouse brain.

19 Aug 2016

New research article reveals global patterns of genetic variation

Published in today's edition of Nature, the research led by Dr Monkol Lek of the University of Sydney and Dr Daniel MacArthur of The Broad Institute of MIT and Harvard Universities reveals patterns of genetic variation worldwide by sequencing the exomes of 60,706 individuals with diverse geographic ancestries, including European, African, South Asian, East Asian and Latino populations.

18 Aug 2016

Nucleotides News and Research

Researchers identify genomic regions linked to ulcerative colitis in African-Americans

Gene variants linked to hot flashes in menopausal women

Study offers promise for therapeutic management of fetal and congenital genetic diseases in utero

TUM scientists develop bioinformatics tool that allows worldwide bacterial analysis

New TSRI study offers surprising twist on how life began on Earth

Study finds no link between milk intake and cardiovascular risk

Synthego introduces CRISPRevolution synthetic sgRNA kit for fast, high-throughput gene editing

New global health strategy aims to eliminate HCV as global public health threat by 2030

Study suggests interactions between distant DNA regions may impact disease gene levels

Penn researchers develop open-source software to infer evolutionary track of tumor metastasis

Research offers new insights into underlying mechanisms of deadly cystic fibrosis

MIT biologists unravel lncRNA structure-to-function relationships

Researchers identify potential new way of treating hypertension

Study reveals vital new details about inner workings of CRISPR-Cas9 machinery in live cells

Preimplantation genetic screening using next generation sequencing: an interview with Dr Luis Alcaraz

Researchers design DNA-based circuit that does math in a test tube

Penn scientists develop combined medical and surgical care plan for managing Crohn's disease

Cloned Zika virus could be used for development of attenuated vaccine

Neuroscientists demonstrate revolutionary new way of mapping the brain at single-neuron resolution

New research article reveals global patterns of genetic variation

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