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Penn State researchers show possible link between partial meltdown at TMI and thyroid cancers

Penn State College of Medicine researchers have shown, for the first time, a possible correlation between the partial meltdown of the Three Mile Island Nuclear Generating Station and thyroid cancers in the counties surrounding the plant.

1 Jun 2017

GW researcher receives NIH funding to explore ways for standardization of cancer genomics data

One of the biggest challenges facing cancer genomics researchers is the lack normalized data on cancer genes. Multitudes of genomics projects have been funded over the years that have resulted in data being placed on several different databases, making a wide array of data and annotations difficult to integrate and compare.

30 May 2017

Investigational compound inhibits cancer-specific mutations in mice

Many malignancies develop as a result of genetic alterations in individual cells. These gene mutations often cause altered proteins that give new, growth-promoting properties to the cell.

30 May 2017

CRISPR may not be as foolproof as earlier believed – gene editing tech leads to unwanted mutations

CRISPR-Cas9 is a revolutionary new gene-editing technology that has been called “molecular scissors” and has been one of the handiest tools for genetic engineers in the recent times. It makes cutting and pasting gene sequences almost as easy as it sounds. CRISPR has been hailed as a breakthrough in genetic engineering.

30 May 2017

Kyoto University researchers identify specific gene as key regulator in iron uptake

Maintaining a good balance of iron in the body is necessary for health: too little can lead to anemia, but too much can cause debilitating disorders such as hemochromatosis.

30 May 2017

Researchers develop new mouse model that could lead to better treatment of kidney cancer

Research in the field of kidney cancer, also called renal cancer, is vital, because many patients with this disease still cannot be cured today.

30 May 2017

Raising age limit for routine genetic testing in colorectal cancer could identify more cases of Lynch syndrome

Raising the age limit for routine genetic testing in colorectal cancer could identify more cases of families affected by Lynch syndrome, a condition that accounts for around 5% of all colon cancers, according to new research to be presented at the annual conference of the European Society of Human Genetics today (Monday).

29 May 2017

FDA approves expanded use of Zykadia for first-line treatment of ALK-positive metastatic NSCLC

Novartis today announced the US Food and Drug Administration approved the expanded use of Zykadia (ceritinib) to include the first-line treatment of patients with metastatic non-small cell lung cancer (NSCLC) whose tumors are anaplastic lymphoma kinase (ALK)-positive, as detected by an FDA-approved test.

27 May 2017

Open-access BRCA testing for inherited breast cancer enables identification of missed carriers

Ashkenazi Jewish women are known to have a predisposition to the inherited breast cancers BRCA1 and BRCA2, but currently genetic testing in this group is limited to women affected by breast and ovarian cancers and those who are unaffected but have a family history of the disease.

27 May 2017

Preliminary study: Co-occurrence of COMT and BRCA 1/2 variants may reduce breast cancer incidence

Research looking at genomic data from women with a genetic risk for breast cancer, who may never develop cancer, found their cancer-free state may be related to a second genetic variation.

25 May 2017

Scientists identify genetic risk factor for equine squamous cell carcinoma

Squamous cell carcinoma (SCC) is the most common cancer found in equine eyes and the second most common tumor of the horse overall. Thanks to a recent genetic study led by UC Davis, horse owners can now identify horses at risk for ocular SCC and make informed breeding decisions.

25 May 2017

UCLA study characterizes brain differences between people with genetic risk for schizophrenia, autism

A UCLA study characterizes, for the first time, brain differences between people with a specific genetic risk for schizophrenia and those at risk for autism, and the findings could help explain the biological underpinnings of these neuropsychiatric disorders.

24 May 2017

Biochemists create new tool to help diagnose POLG disorders and predict outcomes

Providing answers -- or at least more information -- to the most difficult medical questions is the aim of medical scientists. And how research findings are translated and made available can be as important as the discoveries themselves.

24 May 2017

Study shows new promise in the fight against pancreatic cancer

New research from the Keck School of Medicine of the University of Southern California shows new promise in the fight against one of the most lethal forms of cancer.

23 May 2017

Researchers develop simple, flexible technique for early cancer diagnosis

Earlier discovery of cancer and greater precision in the treatment process are the objectives of a new method developed by researchers at Sahlgrenska Academy and Boston University.

22 May 2017

Researchers discover novel mechanism that causes malignant pleural effusion in lung cancer patients

Lung cancer patients are particularly susceptible to malignant pleural effusion, when fluid collects in the space between the lungs and the chest wall. Researchers at the Helmholtz Zentrum München, in partnership with the German Center for Lung Research, have discovered a novel mechanism that causes this to happen.

19 May 2017

New finding could lead to more effective treatment decisions for younger colorectal cancer patients

Younger colon cancer patients appear to have more than three times as many mutations in their tumors as older patients, which could lead to more effective treatment decisions, say researchers at Georgetown Lombardi Comprehensive Cancer Center.

18 May 2017

Researchers identify antibodies that hold promise as Ebola treatments

The fight to contain the 2013-16 Ebola outbreak in West Africa was hampered by the lack of an effective treatment or vaccine. Researchers funded in part by the National Institute of Allergy and Infectious Diseases, part of the National Institutes of Health, have studied the blood of an Ebola survivor, searching for human antibodies that might effectively treat not only people infected with Ebola virus, but those infected with related viruses as well.

18 May 2017

FDA expands approval for cystic fibrosis drug to treat additional rare gene mutations

The U.S. Food and Drug Administration today expanded the approved use of Kalydeco (ivacaftor) for treating cystic fibrosis.

18 May 2017

Targeted therapy appears to be more effective in preventing lung cancer recurrence

The targeted therapy gefitinib appears more effective in preventing recurrence after lung cancer surgery than the standard of care, chemotherapy.

18 May 2017

Mutation News and Research

Penn State researchers show possible link between partial meltdown at TMI and thyroid cancers

GW researcher receives NIH funding to explore ways for standardization of cancer genomics data

Investigational compound inhibits cancer-specific mutations in mice

CRISPR may not be as foolproof as earlier believed – gene editing tech leads to unwanted mutations

Kyoto University researchers identify specific gene as key regulator in iron uptake

Researchers develop new mouse model that could lead to better treatment of kidney cancer

Raising age limit for routine genetic testing in colorectal cancer could identify more cases of Lynch syndrome

FDA approves expanded use of Zykadia for first-line treatment of ALK-positive metastatic NSCLC

Open-access BRCA testing for inherited breast cancer enables identification of missed carriers

Preliminary study: Co-occurrence of COMT and BRCA 1/2 variants may reduce breast cancer incidence

Scientists identify genetic risk factor for equine squamous cell carcinoma

UCLA study characterizes brain differences between people with genetic risk for schizophrenia, autism

Biochemists create new tool to help diagnose POLG disorders and predict outcomes

Study shows new promise in the fight against pancreatic cancer

Researchers develop simple, flexible technique for early cancer diagnosis

Researchers discover novel mechanism that causes malignant pleural effusion in lung cancer patients

New finding could lead to more effective treatment decisions for younger colorectal cancer patients

Researchers identify antibodies that hold promise as Ebola treatments

FDA expands approval for cystic fibrosis drug to treat additional rare gene mutations

Targeted therapy appears to be more effective in preventing lung cancer recurrence

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