immunity News and Research

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Can limiting the priming dose of a SARS-CoV-2 vaccine improve immunity?

Researchers from Northwestern University and the University of Rochester in the U.S. addressed this question in their study. The researchers also explored whether the vaccines administered across the world could confer sterilizing immunity while preventing severe disease and death.

6 Apr 2021

Is non-severe SARS-CoV-2 infection characterized by early T cell proliferation?

To date, little evidence has been documented regarding the immune responses after the onset of the symptoms or virus detection. Further, no cross-sectional studies have been conducted that define the time of infection. Thereby, no report is available that explains the relationship between the earliest immune responses to COVID-19 and temporal kinetics. New research deals with this research gap using blood transcriptomics, multiparameter flow cytometry, and T cell receptor (TCR) sequencing methods.

6 Apr 2021

Colleges and universities plan for normal-ish campus life in the fall

Dr. Sarah Van Orman treads carefully around the word "normal" when she describes what the fall 2021 term will look like at the University of Southern California in Los Angeles and other colleges nationwide.

6 Apr 2021

Novel hydrogel-based vaccine formulation shows high efficacy against SARS-CoV-2

A fascinating new preprint research paper posted to the bioRxiv* server discusses impressively high neutralizing responses elicited with a single dose of a novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine formulation, which could help turn the tide of the current pandemic if validated.

6 Apr 2021

South Africa SARS-CoV-2 variant B.1.351 easily escapes Sputnik vaccine

A new preprint research paper posted to the medRxiv* server reports on vaccine resistance data that pushes the end of the pandemic further away.

6 Apr 2021

Vaccine nationalism reinforces inequities in access and exacerbates health disparities

While the U.S. has begun to vaccinate millions of Americans each day, COVID-19 vaccine supplies around the world remain scarce.

5 Apr 2021

The use of mammalian cell surface display for rapid characterization of SARS-CoV-2 variants

A research group from the U.S. demonstrated the practicality of a spike display system in order to accelerate vaccine design, but also to swiftly appraise the effects of mutations in emerging strains of the SARS-CoV-2.

5 Apr 2021

New approach to CAR T gene therapy yields efficient and longer-lasting response against HIV

A UCLA research team has shown that using a truncated form of the CD4 molecule as part of a gene therapy to combat HIV yielded superior and longer-lasting results in mouse models than previous similar therapies using the CD4 molecule.

3 Apr 2021

Combination of tumor cell vaccine and checkpoint therapy creates effective immune response

A personalized tumor cell vaccine strategy targeting Myc oncogenes combined with checkpoint therapy creates an effective immune response that bypasses antigen selection and immune privilege, according to a pre-clinical study for neuroblastoma and melanoma.

3 Apr 2021

Russian researchers develop a safe, inexpensive packed eggs surface disinfection technology

Russian researchers have developed an inexpensive, safe, and reliable packed eggs surface disinfection technology.

3 Apr 2021

Prioritization of COVID-19 vaccines saves lives, reduces spread of infection

Waiting for your turn can be frustrating, especially when it comes to COVID-19 vaccinations. But prioritizing who receives the limited supply of vaccines available saves lives and reduces spread of infection, according to a study published today in the journal PNAS from the University of California, Davis.

2 Apr 2021

Higher B.1.1.7 transmission in households than other SARS-CoV-2 variants

Contact tracing data from a new preprint study on the medRxiv* preprint server provides further evidence that the B.1.1.7 variant — first reported in the United Kingdom — has a high transmission rate. The research, led by Birgitte Freiseleben de Blasio from the Norwegian Institute of Public Health and the University of Oslo in Norway, estimates B.1.1.7 has a 60% greater transmission within households than other severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern.

2 Apr 2021

Study finds CD8+ T cell responses detect all major SARS-CoV-2 variants

There have been concerns that several SARS-CoV-2 variants have mutations that allow them to evade the immune system. A new study published in the Open Forum Infectious Diseases suggests otherwise. Led by Aaron AR Tobian of Johns Hopkins University School of Medicine, results showed that except for one from the B.1.351 variant, CD8+ T cells showed a broad response to all SARS-CoV-2 variants.

2 Apr 2021

Beating the pavement to vaccinate the underrepresented — and protect everyone

Leonor Garcia held her clipboard close to her chest and rapped on the car window with her knuckles. The driver was in one of dozens of cars lined up on a quiet stretch of road in Adelanto, California, a small city near the southwestern edge of the Mojave Desert.

2 Apr 2021

Can asymptomatic COVID-19 confer long-term immunity?

Researchers examined the antibody responses in symptomatic and asymptomatic individuals recovered from COVID-19 to see if there was a discernable difference in their humoral immune responses and long-term protection from reinfection with SARS-CoV-2.

1 Apr 2021

Researchers develop a recombinant SARS-CoV-2 receptor-binding domain trimer vaccine candidate

New research deals with the development of RBD trimer as a potent target for SARS-CoV-2 subunit vaccines. This study revealed the development of a trimeric RBD subunit vaccine candidate that could induce strong humoral and cellular immune responses in nonhuman primates (NHPs), namely, rhesus macaques.

1 Apr 2021

Oxford-AstraZeneca vaccine effective against B.1.1.7 SARS-CoV-2 variant

Published in The Lancet, the study explores if the Oxford-AstraZeneca vaccine works well in protecting against the B.1.1.7 variant, otherwise known as the U.K. variant.

31 Mar 2021

Antibody tests, even rapid finger pricks, are effective COVID-19 screening tools

New findings from a Michigan Medicine study reveal that antibody testing is predictive of prior COVID-19 infection, and rapid screening methods - even from finger pricks - are effective testing tools.

31 Mar 2021

Risk of SARS-CoV-2 from reinfected individuals with previous infection or vaccination

A technical report recently published by the European Center for Disease Prevention and Control (ECDC) has summarized all available literature regarding the risk of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission from asymptomatic reinfected individuals with a history of SARS-CoV-2 infection or vaccination.

31 Mar 2021

Male fetuses impair the maternal and placental immune response to SARS-CoV-2 infection in pregnancy, finds study

The ongoing COVID-19 pandemic, caused by SARS-CoV-2, is now established to be more likely to lead to symptomatic and serious illness in males relative to females. This may extend as far back as pregnancy, suggests a recent study.

31 Mar 2021

immunity News and Research

Can limiting the priming dose of a SARS-CoV-2 vaccine improve immunity?

Is non-severe SARS-CoV-2 infection characterized by early T cell proliferation?

Colleges and universities plan for normal-ish campus life in the fall

Novel hydrogel-based vaccine formulation shows high efficacy against SARS-CoV-2

South Africa SARS-CoV-2 variant B.1.351 easily escapes Sputnik vaccine

Vaccine nationalism reinforces inequities in access and exacerbates health disparities

The use of mammalian cell surface display for rapid characterization of SARS-CoV-2 variants

New approach to CAR T gene therapy yields efficient and longer-lasting response against HIV

Combination of tumor cell vaccine and checkpoint therapy creates effective immune response

Russian researchers develop a safe, inexpensive packed eggs surface disinfection technology

Prioritization of COVID-19 vaccines saves lives, reduces spread of infection

Higher B.1.1.7 transmission in households than other SARS-CoV-2 variants

Study finds CD8+ T cell responses detect all major SARS-CoV-2 variants

Beating the pavement to vaccinate the underrepresented — and protect everyone

Can asymptomatic COVID-19 confer long-term immunity?

Researchers develop a recombinant SARS-CoV-2 receptor-binding domain trimer vaccine candidate

Oxford-AstraZeneca vaccine effective against B.1.1.7 SARS-CoV-2 variant

Antibody tests, even rapid finger pricks, are effective COVID-19 screening tools

Risk of SARS-CoV-2 from reinfected individuals with previous infection or vaccination

Male fetuses impair the maternal and placental immune response to SARS-CoV-2 infection in pregnancy, finds study

Exploring Strategies for Targeting Kinases in Innate Immunity eBook

How ELRIG Is Helping Mid-Career Scientists Navigate Leadership, Career Change and Redundancy

The role of UV-Vis in biopharma QC

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