immunity News and Research

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Infliximab may hinder the effectiveness of some COVID-19 vaccines

A new study reports reduced vaccine efficacy following the use of a single COVID-19 vaccine dose in people who are on the immunosuppressive monoclonal antibody Infliximab.

31 Mar 2021

Asymmetrical vaccine distribution could promote vaccine evading mutations in SARS-CoV-2

Researchers have investigated the ultimate influence of unequal vaccine distribution by mathematical modeling, revealing the critical role of fair distribution in future COVID-19 containment strategy.

31 Mar 2021

NIAID researchers identify key player in the immune response to SARS-CoV-2

When variants of SARS-CoV-2 (the virus that causes COVID-19) emerged in late 2020, concern arose that they might elude protective immune responses generated by prior infection or vaccination, potentially making re-infection more likely or vaccination less effective.

31 Mar 2021

Study of twins reveals differences in adaptive immunity towards SARS-CoV-2

Twins may look alike on the outside, but not so much on the inside. That's one takeaway from a new preprint study posted to the medRxiv server where Brazilian researchers observed different T-cell responses in two pairs of identical twins exposed to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). One twin who was reinfected with SARS-CoV-2 four months after had low recognition of CD4+ and CD8+ T-cell epitopes.

31 Mar 2021

Single dose of Pfizer and Oxford vaccines shows 60% efficacy in elderly care home residents

A new study deals with the effect of two widely used vaccines in eliciting humoral immunity against the virus in this group. These are the Oxford/AstraZeneca viral-vectored vaccine (ChAdOx1 nCoV-19), and the Pfizer/BioNTech’s messenger RNA-based vaccine (BNT162b2). Both express the viral spike antigen, and both are currently being employed in the UK’s vaccination program.

30 Mar 2021

Study finds rapid increase in IgG and IgA antibody levels following COVID-19 mRNA vaccination

A new study describes the kinetics of the antibody response to the earliest approved vaccines against COVID-19, which were developed on an mRNA platform.

30 Mar 2021

Researchers develop broadly neutralizing SARS-CoV-2 ferritin nanoparticle vaccine

In the continued need for next-generation vaccines that confer broad protection against COVID-19, scientists developed an adjuvanted SARS-CoV-2 Spike Ferritin Nanoparticle (SpFN) vaccine.

30 Mar 2021

Determination of vaccine-elicited SARS-CoV-2 antibodies in breastmilk

A new study has analyzed the levels of SARS-CoV-2 antibodies elicited by the novel COVID-19 vaccines in breastmilk.

30 Mar 2021

Scientists study the sensitivity of SARS-CoV-2 variants to neutralize antibodies

The B.1.1.7 and B.1.351 variants of SARS-CoV-2 were first detected in the UK and South Africa respectively, and have since spread to many other countries.

29 Mar 2021

Vaccine-induced 2C08 antibody protects against SARS-CoV-2 variants

A new preprint study posted to the bioRxiv* server led by Ali H. Ellebedy from the Washington University School of Medicine found that the monoclonal antibody 2C08 produced by the Pfizer vaccine could help neutralize COVID-19 variants.

29 Mar 2021

Have scientists found SARS-CoV-2's Achilles' heel?

Have scientists uncovered the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Achille's heel? New preclinical research from Cell neutralizing antibodies targeting the N-terminal domain of the coronavirus could be a potential target for antibodies to bind and effectively neutralize SARS-CoV-2.

29 Mar 2021

Apes mount a much stronger early immune response compared to African and Asian monkeys

A new study out of the University of Chicago and the University of Illinois Urbana-Champaign in humans, chimpanzees, rhesus macaques and baboons has found key differences in early gene expression in response to pathogen exposure, highlighting the importance of choosing the right animal model for the right questions.

29 Mar 2021

Rare genetic variant may explain severe COVID-19 in young healthy male patients

A recent study describes the association of rare alleles in a specific gene with severe COVID-19 in young male patients.

29 Mar 2021

Researchers develop novel nanoadjuvant COVID-19 vaccine candidate

Researchers at the National Center for Nanoscience and Technology of China, the Chinese Academy of Sciences (CAS), introduced a new vaccine, which compromises the spike protein’s receptor-binding domain (RBD) and the manganese nanoadjuvant (MnARK), inducing humoral and cellular responses.

29 Mar 2021

In his continued sparring with Fauci, Sen. Rand Paul oversimplified the science

That Sen. Rand Paul of Kentucky often disagrees with infectious-disease expert Dr. Anthony Fauci is well known.

29 Mar 2021

Single Sputnik V vaccine dose elicits robust immune response in previously infected individuals

A new preprint research paper posted to the medRxiv server describes successful immunization of the vaccinated population with a single dose of the Russian-made Sputnik V vaccine.

29 Mar 2021

Linear epitope mapping of the SARS-CoV-2 spike protein

The spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been the primary target of many drug discovery efforts and is similarly utilized in each of the approved COVID-19 vaccines to elicit the generation of anti-spike protein antibodies, thereby granting immunity.

28 Mar 2021

New project receives $9 million CIHR funding to track global threat of COVID-19 variants

A project spearheaded by a researcher at the University of Ottawa's Faculty of Medicine has been awarded $9 million in Canadian Institutes of Health Research (CIHR) funding to create a national network for better researching and responding to the global threat COVID-19 variants pose.

26 Mar 2021

Longitudinal study of SARS-CoV-2 antibodies following vaccination

A longitudinal study of IgG antibody levels in vaccinated healthcare workers was recently uploaded to the preprint server medRxiv*, suggesting that IgG levels could be a reliable indicator of successful vaccination.

26 Mar 2021

One dose of Pfizer vaccine generates strong immune response against COVID-19

A new study led by the Universities of Sheffield and Oxford with support from the UK Coronavirus Immunology Consortium (UK-CIC) has found that 99 per cent of people generate a robust immune response against Covid-19 after just one dose of the Pfizer vaccine.

26 Mar 2021

immunity News and Research

Infliximab may hinder the effectiveness of some COVID-19 vaccines

Asymmetrical vaccine distribution could promote vaccine evading mutations in SARS-CoV-2

NIAID researchers identify key player in the immune response to SARS-CoV-2

Study of twins reveals differences in adaptive immunity towards SARS-CoV-2

Single dose of Pfizer and Oxford vaccines shows 60% efficacy in elderly care home residents

Study finds rapid increase in IgG and IgA antibody levels following COVID-19 mRNA vaccination

Researchers develop broadly neutralizing SARS-CoV-2 ferritin nanoparticle vaccine

Determination of vaccine-elicited SARS-CoV-2 antibodies in breastmilk

Scientists study the sensitivity of SARS-CoV-2 variants to neutralize antibodies

Vaccine-induced 2C08 antibody protects against SARS-CoV-2 variants

Have scientists found SARS-CoV-2's Achilles' heel?

Apes mount a much stronger early immune response compared to African and Asian monkeys

Rare genetic variant may explain severe COVID-19 in young healthy male patients

Researchers develop novel nanoadjuvant COVID-19 vaccine candidate

In his continued sparring with Fauci, Sen. Rand Paul oversimplified the science

Single Sputnik V vaccine dose elicits robust immune response in previously infected individuals

Linear epitope mapping of the SARS-CoV-2 spike protein

New project receives $9 million CIHR funding to track global threat of COVID-19 variants

Longitudinal study of SARS-CoV-2 antibodies following vaccination

One dose of Pfizer vaccine generates strong immune response against COVID-19

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