Malignant News and Research

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Onconase granted orphan drug status for malignant mesothelioma in Australia

Alfacell Corporation has announced that the Therapeutic Goods Administration (TGA) in Australia has granted Onconase (ranpirnase) Orphan Drug status for the indication of malignant mesothelioma (MM). Onconase is also designated as an Orphan Drug for MM in Europe.

28 Mar 2005

Diffusion MRI gives early indication if brain cancer therapy is effective

A special type of MRI scan that measures the flow of water molecules through the brain can help doctors determine early in the course of brain cancer regimen if a patient's tumor will shrink, a new study shows.

28 Mar 2005

NHS target driven culture is failing patients

The new tick box, target driven culture of the NHS is neglecting the quality of patient care, warns a senior doctor in this week's BMJ.

28 Mar 2005

Skin cancer on the rise in the UK

Melanoma is the second most common cancer among people aged 15-34 and researchers say sunburn in childhood can double the risk of melanoma in later life. In the UK over 7,300 cases of malignant melanoma are diagnosed each year and 1,700 people die of the disease.

22 Mar 2005

Study suggests combination therapy could stop spread, halt growth of melanomas

Researchers at Penn State College of Medicine have identified the mechanism by which the most mutated gene in melanoma, called v599EB-Raf, aids melanoma tumor development demonstrating its importance as a therapeutic target.

22 Mar 2005

Genomic DNA provides clues to new advances in cancer diagnostics

Researchers at the University of Illinois at Chicago have identified a method of assessing the malignant potential of cells based on the sensitivity of cellular DNA to enzyme digestion.

22 Mar 2005

Findings are expected to yield new diagnostic and therapeutic tools in the battle against cancer

New laboratory findings at the University of Illinois at Chicago suggest that what lies outside cancer cells is at least as important as the genes inside in explaining a tumor's malignancy.

22 Mar 2005

Discovery of a single mutation responsible for a number of blood disorders

Myeloproliferative disorders form a range of haematological malignant diseases, with three main members: polycythaemia vera, essential thrombocythaemia, and idiopathic myelofi- brosis. The disorders are characterised by overactive production of blood cells and can lead to thrombosis, haemorrhage or acute myeloid leukaemia.

21 Mar 2005

Approval for Temodar (temozolomide) capsules for newly diagnosed glioblastoma multiforme

Schering-Plough today reported that the U.S. Food and Drug Administration (FDA) has granted approval for Temodar (temozolomide) Capsules for use in combination with radiotherapy for the treatment of adult patients with newly diagnosed glioblastoma multiforme (GBM), a form of malignant brain cancer.

16 Mar 2005

Patients can now swallow pill-sized, disposable cameras to help diagnose diseases of the esophagus

Patients can now swallow pill-sized, disposable cameras to help gastroenterologists diagnose and evaluate diseases of the esophagus, or swallowing tube. This new diagnostic tool is a further modification of capsule endoscopy, which has been used clinically since late 2001 to examine the small intestines.

15 Mar 2005

Doctors may in future be able to prevent many cases of deep-vein thrombosis

Doctors may in future be able to prevent many cases of deep-vein thrombosis, commonly referred to as DVT, a disease of the circulation that causes potentially fatal blood clots. It occurs most often in people who have not been able to exercise normally.

9 Mar 2005

New chemotherapy gives hope to brain tumour patients

A large international study conducted by the European Organisation for Research and Treatment of Cancer (EORTC) in collaboration with the National Cancer Institute of Canada (NCIC) Clinical Trials Group demonstrated that the addition of a novel chemotherapy agent, Temozolomide (brand name: Temodal®) to radiation therapy increases survival in patients suffering from glioblastoma, a very aggressive form of a brain tumour.

9 Mar 2005

Revlimid results look promising for multiple myeloma patients

The Multiple Myeloma Research Foundation (MMRF) applauded today's Celgene announcement regarding Revlimid, a new class of novel immunomodulatory drugs currently being evaluated to treat a broad range of hematology and oncology conditions, including multiple myeloma.

8 Mar 2005

MRI useful in assessment of suspected breast cancer patients

If a mammogram or sonogram suggests that a woman has breast cancer, an MRI should be done to help determine whether there actually is a cancer and if so, what are the woman’s best treatment options, a new study shows.

6 Mar 2005

Important advance in our understanding of colorectal cancer

An international team of medical scientists has made an important advance in our understanding of the second most fatal form of cancer in the industrialized world. Professor Jeremy R. Jass, who holds a Canada Research Chair in Gastrointestinal Pathology at McGill University in Montreal

3 Mar 2005

Important player in the development of colon cancer

Cancer growth is a long, complex, multi-stage process involving a variety of different "players." This complexity is part of the difficulty facing cancer researchers. Meanwhile, each discovery or identification of a new "player," or previously unknown stage in the process, offers new opportunities for blocking the disease.

3 Mar 2005

More experienced physicians less likely to falsely characterize a mammogram as abnormal

Physicians who specialize in screening mammography and who have at least 25 years of experience are more accurate at interpreting the images and subject fewer women to the anxiety of false positives for cancer, when compared to physicians with less experience or those who don't have the same focus, according to a new study.

1 Mar 2005

Importance of Fbw7 as an emerging tumor suppressor

The DNA tumor virus simian virus 40 produces the Large T antigen which inactivates two of the cell's most important cancer-preventing proteins, p53 and pRb.

27 Feb 2005

New imaging method that may provide a clearer diagnosis of breast cancer

"This technique involves a new method for interpreting information gathered through MRI," explained Springer. "The technique involves recognizing that certain properties of MRI signals can change during the examination, much like the changing of a camera's shutter speed.

24 Feb 2005

Sir Bobby Robson opens state-of-the-art research centre

Cancer survivor Sir Bobby Robson marked the official opening of a state-of-the-art research centre by meeting the doctors and scientists using its facilities to help patients.

23 Feb 2005