Mouse Model News and Research

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18 to 25 percent of women suffer from migraines

For every man with a migraine, three women are struck by the severe headaches that often come with nausea, sensitivity to light and sound, and aura.

6 Aug 2007

Lithium promotes better bone healing

Researchers at The Hospital for Sick Children (SickKids) have found a molecular pathway that plays a critical role in bone healing and have found that the drug lithium can improve the healing process.

1 Aug 2007

Reducing inflammation plays key role in type 1 diabetes therapy

Researchers at Beth Israel Deaconess Medical Center (BIDMC) have found that a triple combination therapy consisting of both tolerance-inducing and anti-inflammatory properties is successful in abolishing adverse autoimmunity against insulin-producing cells in a mouse model of Type 1 diabetes.

1 Aug 2007

First mouse model of schizophrenia

Johns Hopkins researchers have genetically engineered the first mouse that models both the anatomical and behavioral defects of schizophrenia, a complex and debilitating brain disorder that affects over 2 million Americans.

1 Aug 2007

New understanding of Sly Syndrome

The scientist who discovered “Sly Syndrome” nearly four decades ago and a team of colleagues at Saint Louis University are a step closer to finding an approach to treat the rare genetic disease.

26 Jul 2007

The future of Alzheimer's disease research

Imagine the day when a routine visit to the family doctor includes a simple blood test to predict the risk for developing Alzheimer's disease (AD).

26 Jul 2007

Antibody targets nanotubes to tumors

Researchers at Memorial Sloan-Kettering Cancer Center have created biocompatible single-walled carbon nanotubes that can target lymphomas and deliver both imaging and therapeutic molecules to these tumors.

23 Jul 2007

RNA essential for survival of mature neurons

There are lots of things that brain cells need to survive. Add to that list microRNAs.

19 Jul 2007

St. Jude study holds promise for improving neuroblastoma treatment

A treatment for neuroblastoma that lands a one-two punch works best when the second punch is timed to take maximum advantage of the first one, according to results of studies at St. Jude Children's Research Hospital.

12 Jul 2007

First mouse model of lung transplantation

Lung transplants have been performed successfully for more than 20 years in humans but never before in mice – until now.

12 Jul 2007

Potential new treatment pathway for Parkinson's

In the vast majority of Parkinson's disease (PD) patients, the disorder arises not because of a genetic defect, but because some external insult triggers the death of dopamine-producing neurons.

9 Jul 2007

Gene found that protects from serious kidney disease

A combination of mice and patient studies sheds light on cause and possible new therapies of kidney diseases.

8 Jul 2007

Discovery of two effective antibodies for SARS

An international team of investigators has identified the first human antibodies that can neutralize different strains of the virus responsible for outbreaks of severe acute respiratory syndrome (SARS).

4 Jul 2007

Omega-3 polyunsaturated fatty acids protect against retinopathy

Omega-3 polyunsaturated fatty acids protect against the development and progression of retinopathy, a deterioration of the retina, in mice.

26 Jun 2007

Basically eating fish may protect against type of blindness

Increasing intake of the omega-3 fatty acids DHA and EPA, found in popular fish-oil supplements, may protect against blindness resulting from abnormal blood vessel growth in the eye, according to a study published online by the journal Nature Medicine on June 24.

26 Jun 2007

Vaccine for human cytomegalovirus

Researchers at the University of California, San Diego (UCSD) Skaggs School of Pharmacy and Pharmaceutical Sciences have patented a strategy for developing a human vaccine to prevent against Human Cytomegalovirus (hCMV) infection and disease.

23 Jun 2007

DNA repair by Brca2 prevents medulloblastoma

St. Jude investigators have gained some of the first major insights into how certain genes known to prevent cancer also guide the nervous system's normal development before birth and during infancy by repairing DNA damage.

23 Jun 2007

Smoking affects ligament healing

The list of reasons you shouldn't smoke has gotten longer. Researchers at Washington University School of Medicine in St. Louis are reporting that smoking interferes with ligament healing.

23 Jun 2007

New target for therapies for retinopathy

A protein long thought to be one of the body's supporting players has quietly been taking a lead role in healthy eyesight, a discovery that could rapidly lead to treatments for babies born before their eyes are finished growing, University of Florida and Harvard Medical School researchers have found.

19 Jun 2007

Researchers clarify alphaB-crystallin's role in multiple sclerosis

A protein found primarily in the lens of the eye could be the critical "tipping point" in the spiral of inflammation and damage that occurs in multiple sclerosis, researchers at the Stanford University School of Medicine report.

18 Jun 2007