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New clinical trial to evaluate DEX-M74 against hereditary inclusion body myopathy

Researchers have launched a clinical trial to evaluate the drug candidate DEX-M74 as a treatment for a rare degenerative muscle disease, hereditary inclusion body myopathy (HIBM). National Institutes of Health scientists from the National Center for Advancing Translational Sciences (NCATS) and the National Human Genome Research Institute (NHGRI) will conduct the clinical trial at the NIH Clinical Center.

25 Sep 2012

UCLA/Pitt scientists uncover P. acnes virus with potential to kill zits

Watch out, acne. Doctors soon may have a new weapon against zits: a harmless virus living on our skin that naturally seeks out and kills the bacteria that cause pimples.

25 Sep 2012

New technique allows cells to make terpenes

Scientists at The Scripps Research Institute have shown how to synthesize in the laboratory an important set of natural compounds known as terpenes. The largest class of chemicals made by living organisms, terpenes are made within cells by some of the most complex chemical reactions found in biology.

24 Sep 2012

Sleep medicine and research: an interview with James K. Walsh

There are a variety of sleep medicines. I am going to refer to what are commonly described as hypnotics or sleeping pills. Sleeping pills have been around for a long time.

24 Sep 2012

Boehringer Ingelheim completes enrollment in nintedanib Phase III trials for IPF

Boehringer Ingelheim is pleased to announce the last patients have been randomised into the Phase III sister trials assessing the efficacy and safety of nintedanib (150 mg twice daily) in patients with idiopathic pulmonary fibrosis (IPF).

24 Sep 2012

Sanofi, TB Alliance form research collaboration to search for new treatment compounds

French drug maker Sanofi on Thursday announced a new three-year research collaboration agreement with the TB Alliance "to accelerate the discovery and development of novel compounds against tuberculosis," RTTNews reports.

21 Sep 2012

Exposures to perchlorate could reduce thyroidal iodine uptake in women and fetuses

Exposures to perchlorate (ClO4), a compound found at low levels in the environment, and thiocyanate (SCN), a compound found in cigarette smoke and some foods, is unlikely to alter thyroid function in pregnant women and fetuses, according to new data presented at the 82nd Annual Meeting of the American Thyroid Association (ATA) in Québec City, Québec, Canada.

21 Sep 2012

Investigators identify two promising therapies to treat patients with acute megakaryocytic leukemia

Investigators at Northwestern University Feinberg School of Medicine have identified two promising therapies to treat patients with acute megakaryocytic leukemia (AMKL), a rare form of leukemia where the number of cases is expected to increase with the aging population.

21 Sep 2012

ChromaDex announces findings from pTeroPure Phase 2/3 trial on high blood pressure

ChromaDex Corporation announced today findings from a Phase 2/3 trial at the University of Mississippi Medical Center showing its patented nutritional ingredient pTeroPure (pterostilbene) significantly reduced blood pressure in adults.

21 Sep 2012

Researchers use nanoparticles to deliver drugs to mitochondria within cells

Nanoparticles have shown great promise in the targeted delivery of drugs to cells, but researchers at the University of Georgia have refined the drug delivery process further by using nanoparticles to deliver drugs to a specific organelle within cells.

21 Sep 2012

Study finds high levels of ESBL bacteria in Danish chicken meat

Nearly half of the samples from chicken meat imported into Denmark contain ESBL bacteria and for the first time the level is almost as high in Danish chicken meat. By contrast, the occurrence in Danish pigs has decreased significantly since farmers stopped using cephalosporins for pigs.

20 Sep 2012

PCA inhibits multiple pathways involved in development of diabetic nephropathy

Diabetic nephropathy is one of the most serious complications related to diabetes, often leading to end-stage kidney disease. Purple corn grown in Peru and Chile is a relative of blue corn, which is readily available in the U.S.

20 Sep 2012

Mushroom compound lengthens lives of dogs with cancer, has human potential

Dogs with splenic hemangiosarcoma had significantly delayed metastatic progression and lived longer than any previously recorded time after treatment with an extract of the mushroom Coriolus versicolor, report US investigators.

19 Sep 2012

Positive data from Aprea’s APR-246 Phase I/II study on blood or prostate cancer

Aprea today announced positive data from a completed Phase I/II clinical study with its investigational drug APR-246. The results from the study have been published in the Journal of Clinical Oncology.

18 Sep 2012

vasopharm's explorative phase IIa NOSTRA trial in TBI meets clinical endpoints for safety

vasopharm GmbH, a pharmaceutical company dedicated to the discovery and development of novel therapeutics for the treatment of cerebro- and cardiovascular diseases, today announces that the explorative phase IIa NOSTRA trial in Traumatic Brain Injury Patients met all clinical endpoints for safety and in addition demonstrated strong evidence of clinical benefit in patients.

17 Sep 2012

Hyperuricemia associated with more severe hepatic ATP depletion in response to fructose intake

Obese patients with type 2 diabetes who consume higher amounts of fructose display reduced levels of liver adenosine triphosphate (ATP)—a compound involved in the energy transfer between cells.

14 Sep 2012

Pam2Cys nasal spray may be useful agent against pandemics and emerging viral strains

In an advance toward development of a nasal spray that protects against infection with influenza and spread of the disease, scientists are reporting identification of a substance that activates the first-line defense system against infection inside the nose. They describe effects of a synthetic form of a natural substance found in bacterial cell walls in ACS' journal Molecular Pharmaceutics.

13 Sep 2012

Aethic, King's College London to develop first sunscreen based on mycosporine-like amino acids

King's College London has entered into an agreement with skincare company Aethic to develop the first sunscreen based on MAA's (mycosporine-like amino acids), produced by coral.

12 Sep 2012

Palatin fourth quarter revenues decrease to $11,000

Palatin Technologies, Inc., a biopharmaceutical company developing targeted, receptor-specific peptide therapeutics for the treatment of diseases with significant unmet medical need and commercial potential, today announced results for its fourth quarter and fiscal year ended June 30, 2012.

11 Sep 2012

Polysaccharopeptide improves survival in dogs with hemangiosarcoma

Dogs with hemangiosarcoma that were treated with a compound derived from the Coriolus versicolor mushroom had the longest survival times ever reported for dogs with the disease.

11 Sep 2012

Compound News and Research

New clinical trial to evaluate DEX-M74 against hereditary inclusion body myopathy

UCLA/Pitt scientists uncover P. acnes virus with potential to kill zits

New technique allows cells to make terpenes

Sleep medicine and research: an interview with James K. Walsh

Boehringer Ingelheim completes enrollment in nintedanib Phase III trials for IPF

Sanofi, TB Alliance form research collaboration to search for new treatment compounds

Exposures to perchlorate could reduce thyroidal iodine uptake in women and fetuses

Investigators identify two promising therapies to treat patients with acute megakaryocytic leukemia

ChromaDex announces findings from pTeroPure Phase 2/3 trial on high blood pressure

Researchers use nanoparticles to deliver drugs to mitochondria within cells

Study finds high levels of ESBL bacteria in Danish chicken meat

PCA inhibits multiple pathways involved in development of diabetic nephropathy

Mushroom compound lengthens lives of dogs with cancer, has human potential

Positive data from Aprea’s APR-246 Phase I/II study on blood or prostate cancer

vasopharm's explorative phase IIa NOSTRA trial in TBI meets clinical endpoints for safety

Hyperuricemia associated with more severe hepatic ATP depletion in response to fructose intake

Pam2Cys nasal spray may be useful agent against pandemics and emerging viral strains

Aethic, King's College London to develop first sunscreen based on mycosporine-like amino acids

Palatin fourth quarter revenues decrease to $11,000

Polysaccharopeptide improves survival in dogs with hemangiosarcoma

Advancing therapeutic biopolymer development eBook

Improving healthcare sustainability through carbon data

A New Approach to Preventing Bladder Cancer Recurrence

Bringing real-time analytics to downstream bioprocess monitoring

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