Mouse Model News and Research

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Gene mutation explains type of brittle bone disease

A newly identified gene mutation helps explain a subset of cases of osteogenesis imperfecta (OI), or brittle bone disease, whose origin had until now remained mysterious.

20 Oct 2006

Heme oxygenase-1 protects against lung damage in silicosis

Levels of heme oxygenase-1 (HO-1), an antioxidant that protects against reactive oxygen species (damaging oxygen molecules that cause direct tissue injury), become elevated in the lungs of chronic silicosis patients and could represent a new treatment approach for the disease.

16 Oct 2006

Cabernet Sauvignon may reduce incidence of Alzheimer's Disease

A new study directed by Mount Sinai School of Medicine has found that moderate red wine consumption in a form of Cabernet Sauvignon may help reduce the incidence of Alzheimer's Disease (AD).

20 Sep 2006

Carbon monoxide shown to reverse symptoms of pulmonary hypertension

In a medical case of Jekyll and Hyde, carbon monoxide - the highly toxic gas emitted from auto exhausts and faulty heating systems - has proven effective in treating the symptoms of pulmonary arterial hypertension (PAH), an extremely debilitating condition that typically leads to right heart failure and eventual death.

20 Sep 2006

Nicotinamide may help people with multiple sclerosis

Researchers have found a possible way to protect people with multiple sclerosis (MS) from severe long-term disability: increase nervous-system levels of a vital compound, called nicotinamide adenine dinucleotide (NAD), by giving its chemical precursor - nicotinamide, a form of vitamin B3.

19 Sep 2006

New class of super NSAIDs

Building on previous work, researchers at the University of Pennsylvania School of Medicine have found that deleting an inflammation enzyme in a mouse model of heart disease slowed the development of atherosclerosis.

12 Sep 2006

Useful insights into mechanisms of catecholaminergic polymorphic ventricular tachycardia

World Congress of Cardiology Report - Familial genetic defects are responsible for several cases of unexpected sudden cardiac death in young and otherwise healthy individuals.

5 Sep 2006

First treatment for Hunter disease

An article reporting results from a pivotal clinical trial that helped gain U.S. Food and Drug Administration approval for the first treatment for Hunter disease has been published online by the journal Genetics in Medicine.

16 Aug 2006

New findings support Rapamycin's role as cancer treatment

Scientists have long known that the blood vessels of tumors differ markedly from normal blood vessels.

14 Aug 2006

Enrichment of regulatory CD4+CD25+ T cells by inhibition of phospholipase D signaling

A signaling molecule with an affinity for alcohol has yielded a rapid, inexpensive way to make large numbers of immune cells that work like beat cops keeping misguided cells from attacking the body.

8 Aug 2006

Gene amplification links growth controlling pathway from Drosophila to human cancers

Researchers at Harvard Medical School (HMS) and Massachusetts General Hospital (MGH) have discovered a new cancer-promoting role for a gene potentially involved in breast, liver, and other kinds of cancers.

8 Aug 2006

For the first time, scientists watch neurons change in response to experience

Thanks to a new imaging system, researchers at MIT's Picower Institute for Learning and Memory have gotten an unprecedented look into how genes shape the brain in response to the environment.

6 Aug 2006

New way of delivering corrective genes holds promise for hereditary diseases of the heart

A new way of delivering corrective genes with a single injection into a vein holds promise for long-lasting treatments of hereditary diseases of the heart, University of Florida researchers report.

6 Aug 2006

Researchers identify how molecules of microRNA are responsible for the growth of blood vessels in a model for human colon cancer

The process, called angiogenesis, results in ability of ravenous cancer cells to recruit blood vessels and receive a steady supply of nutrients and oxygen.

4 Aug 2006

Researchers determine why gene therapy treatment caused leukemia in some X-linked severe combined immunodeficiency patients

Scientists at St. Jude Children's Research Hospital have developed a mouse model of a severe disease of the immune system that helps explain why gene therapy used to treat children with this disease at an institution in Europe caused some of them to develop leukemia.

2 Aug 2006

Altering fatty acid levels in diet may reduce prostate cancer growth rate

UCLA researchers found that altering the fatty acid ratio found in the typical Western diet to include more omega-3 fatty acids and decrease the amount of omega-6 fatty acids may reduce prostate cancer tumor growth rates and PSA levels.

2 Aug 2006

New genetic model for Parkinson's disease

Researchers at the Karolinska Institute in Sweden are homing in on mechanisms that may explain one set of causes for Parkinson's disease.

1 Aug 2006

Research findings may speed the development of vaccines for Chlamydia and other STDs

Using a novel mouse model that allows scientists to study how the immune system’s fighter cells respond to invaders in the genital tract during the initial stage of infection, researchers have found a way to track immunity against Chlamydia trachomatis.

26 Jul 2006

Scientists slow vision loss with vitamin E, alpha-lipoic acid and other antioxidant chemicals

Scientists at Johns Hopkins have successfully blocked the advance of retinal degeneration in mice with a form of retinitis pigmentosa (RP) by treating them with vitamin E, alpha-lipoic acid and other antioxidant chemicals.

24 Jul 2006

Link between psychological stress and ovarian tumor growth

When mice with ovarian cancer are stressed, their tumors grow and spread more quickly, but that effect can be blocked using a medication commonly prescribed for heart disease.