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Gut microbiome may reveal inflammation and future disease risk better than age

Gut microbiota composition explained more variation than chronological age in nearly all inflammatory cytokines and most physiological measures examined, with specific microbial profiles linked to markedly different patterns of inflammation across adulthood. People with the Bacteroides 2 enterotype showed an inflammaging-like profile decades earlier than other groups and had a higher risk of subsequent disease, while a high-diversity microbiota profile was associated with lower inflammation and reduced disease incidence.

9 Sep 2026

Pink noise boosts brain waste clearance during sleep

During the day, waste products such as lactic acid and worn-out proteins build up in the brain. When we sleep at night, waves of cerebrospinal fluid (CSF) help to wash away this waste, keeping the brain healthy.

9 Sep 2026

Technological roadmap proposed for lifetime brain-wide neural recordings

Understanding the brain requires tools that can follow neural activity across many scales: from millisecond electrical spikes in individual neurons to brain-wide circuit dynamics that change over months, years, and even a lifetime.

9 Sep 2026

Caloric restriction reduces genetic mutations across the mouse genome

Mutations are changes in the molecular "letters" that make up DNA, the genetic blueprint for cells. Mutations build up with age in every cell when DNA is damaged or when cells make mistakes in fixing or copying it.

9 Sep 2026

New blood screening algorithm reduces unnecessary Alzheimer's PET scans

A new blood-based screening algorithm dramatically reduced the number of unnecessary PET scans needed to recruit patients at risk of Alzheimer's disease for a clinical trial, according to research from scientists at the Keck School of Medicine of USC published in Alzheimer's & Dementia: The Journal of the Alzheimer's Association.

9 Sep 2026

Cognitive behavioral therapy for insomnia may slow biological aging in older adults

A new UCLA Health study found that treatment of insomnia using cognitive behavioral therapy slowed the pace of biological aging in older adults.

8 Sep 2026

Hormone therapy during menopause transition associated with lower heart disease risk

A study led by Virginia Commonwealth University and the University of Pittsburgh provides pivotal insights into one of the most debated questions in women's health: how does hormone therapy for menopause symptoms affect cardiovascular disease risk when used in peri- or early postmenopause?

8 Sep 2026

Could one amino acid help explain why men tend to live shorter lives?

A UK Biobank cohort and Mendelian randomization study involving 272,475 participants linked higher circulating tyrosine with greater all-cause mortality and genetically predicted higher tyrosine with shorter lifespan. After accounting for phenylalanine, the relationship with shorter lifespan was clearest in men, while findings in women were less consistent, suggesting a potential sex-specific role for tyrosine in longevity.

7 Sep 2026

AI-designed drug candidate reverses biological age in clinical study

Insilico Medicine ("Insilico"), a clinical-stage company focused on generative AI-driven drug discovery and development, today announced the publication of a new study conducted in collaboration with an international team of scientists from Harvard Medical School, Stanford University, The Broad Institute, RWTH Aachen University, Peking University and Westlake University.

7 Sep 2026

Scientists traced a hidden immune route that may worsen tau-linked brain damage

In a mouse model of tauopathy, conventional type 1 dendritic cells (cDC1s) cross-presented brain-derived antigens in deep cervical lymph nodes, priming CD8+ T cells that accumulated in the brain and promoted neurodegeneration. Disrupting cDC1s or their cross-presentation activity reduced CD8+ T-cell infiltration and protected against neuronal loss, while human primary tauopathy samples also showed increased brain CD8+ T cells, although cDC1 involvement in humans remains unconfirmed.

6 Sep 2026

Yoga with a cognitive twist showed some intriguing benefits in older adults

A 24-week pilot randomized trial found that both traditional Hatha yoga and a faster, cognitively demanding YogaCue program were associated with improvements in cognitive and physical performance in independently living older adults. YogaCue showed promising additional gains in verbal and episodic memory, aerobic fitness, and lower-body power, although the small study could not establish clear superiority over Hatha yoga across all outcomes.

6 Sep 2026

Microplastics transport toxins and antibiotic resistance across ecosystems

Microplastics are often viewed as pollutants in their own right, but their environmental impact may extend far beyond the plastic particles themselves.

4 Sep 2026

Mitochondrial stress triggers long-term protection against heart damage

Mitochondria are popularly known as the "powerhouse of the cell," but these cellular structures do so much more-including acting as signaling hubs.

4 Sep 2026

Younger and older brains respond differently to traumatic injury

Conventional wisdom holds that younger brains are better equipped to recover from injury. Their greater flexibility allows them to adapt, rebuild connections and compensate for damage in ways older brains often cannot.

4 Sep 2026

Independent review reinforces value of vaccines across all ages

The Gerontological Society of America (GSA) supports the 2026-27 respiratory season vaccine evidence review released on September 2, 2026, by the Vaccine Integrity Project (VIP) in collaboration with the American Medical Association.

4 Sep 2026

High-energy tissues rely on macrophages to clear cellular waste

The body's heart muscle (for pumping blood), skeletal muscle (for movement and posture), and brown fat (for heat production), each require a lot of energy and make a lot of waste. And that waste needs to be managed.

4 Sep 2026

Community brain health programs successfully improve attention in older adults

As aging populations drive rising global healthcare demands, finding scalable ways to prevent cognitive decline has become a vital public health priority.

4 Sep 2026

Misfolded proteins slip past cell cleanups and risk causing disease

As proteins are made in a cell, they are folded into the 3-D structure that allows them to work, but sometimes this process can go wrong.

4 Sep 2026

What your gut microbes may have to do with how your brain ages

This review examines how diet-driven changes in the gut microbiota and microbial metabolites may influence cognitive aging through immune, metabolic, neural, endocrine, and barrier-related pathways. It highlights SCFAs, tryptophan-derived metabolites, and bile acids as key signaling mediators while emphasizing that much of the mechanistic evidence remains preclinical and human evidence is largely associative.

3 Sep 2026

What your genes can, and cannot, tell us about your personality

A meta-analysis of 46 cohorts involving 611,037 to 1.14 million participants identified 1,260 lead genetic variants associated with the Big Five personality traits, including 824 in previously unlinked genomic regions. The associations were broadly consistent across cohorts and measurement contexts, while polygenic analyses linked personality-related genetics to health, behavior, psychopathology, and life outcomes, although effects were modest and could not predict individual behavior.

3 Sep 2026