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Higher meat intake may slow cognitive decline in older adults with APOE ε4

In older Swedish adults, higher meat intake was associated with slower cognitive decline and lower dementia risk among people carrying APOE ε3/ε4 or ε4/ε4, but not among other genotype groups. A higher processed-to-total meat ratio was linked to worse dementia outcomes, while unprocessed red meat and poultry showed no substantial difference.

22 Mar 2026

Genetic risk for Alzheimer's disease may be modified by higher meat intake

Older people with a genetic risk of Alzheimer's disease did not experience the expected increase in cognitive decline and dementia risk if they consumed relatively large amounts of meat.

19 Mar 2026

Siemens Healthineers launches brain health research portfolio with first biomarker assays now available

Siemens Healthineers announced today its offerings for brain health research are expanding, with the brain-derived, fully automated Atellica IM Phosphorylated tau 217 (pTau217) and Atellica IM Brain Derived Tau (BDTau) assays now available for 1.

From Siemens Healthineers 19 Mar 2026

Menopause may raise women’s Alzheimer risk earlier than doctors once thought

This review argues that women’s higher Alzheimer disease risk may be shaped in part by midlife neuroendocrine aging, especially the menopause transition, rather than by longevity alone. It highlights early menopause, bilateral oophorectomy, vasomotor symptoms, and midlife cognitive changes as underinvestigated but potentially important risk markers, while calling for sex-specific, biomarker-driven prevention strategies.

18 Mar 2026

Updated guideline emphasizes earlier treatment for high cholesterol

The American College of Cardiology (ACC), the American Heart Association and nine other leading medical associations, today issued an updated guideline for the management of dyslipidemia-abnormal levels of one or more types of lipids or lipoproteins in the blood, including cholesterol and triglycerides.

13 Mar 2026

Blood protein structure changes may enable earlier detection of Alzheimer’s

Advanced proteomics and AI reveal blood protein changes, offering insights into early Alzheimer's detection and differentiation from mild cognitive impairment.

13 Mar 2026

Blood protein structure changes may reveal early signs of Alzheimer’s

Alzheimer's disease affects an estimated 7.2 million Americans age 65 and older, according to the Alzheimer's Association.

9 Mar 2026

BCAT2 enzyme identified as a target for diabetic foot recovery

Diabetic macrovascular complications are the main cause of death and disability in diabetes patients, of which vascular calcification is one of the key pathological mechanisms. Calcification in atherosclerotic plaque can cause stiffness and decreased compliance of the vascular wall, and induce atherosclerotic plaque rupture, which increases the risk of acute cardiovascular events.

6 Mar 2026

IFN-γ identified as a powerful blood biomarker for Alzheimer’s

This study identifies IFN-γ as a crucial blood-based biomarker for Alzheimer's, revealing its role in microglial inflammation and genetic risk interactions.

19 Feb 2026

Does motherhood influence brain aging? New research suggests a positive cognitive association

Longitudinal data from postmenopausal women suggest that cumulative pregnancy duration and breastfeeding history are associated with modestly better cognitive performance later in life. These associations reflect higher cognitive trajectory levels rather than proven slowing of decline, and causality remains uncertain.

5 Feb 2026

Unraveling liver injury mechanisms in familial hypobetalipoproteinemia

Familial Hypobetalipoproteinemia (FHBL), caused by variants in the apolipoprotein B (APOB) gene, is a rare autosomal co-dominant monogenic disorder characterized by lifelong low plasma levels of total cholesterol, low-density lipoprotein cholesterol (LDL-C), and APOB.

24 Jan 2026

APOE gene: A major driver in Alzheimer's disease

Potentially more than 90% of Alzheimer's disease cases would not occur without the contribution of a single gene (APOE), according to a new analysis led by UCL researchers.

9 Jan 2026

High-fat cheese and cream consumption links to lower dementia risk over 25 years

Higher intake of high-fat cheese and cream was associated with a lower risk of all-cause dementia over 25 years in a large Swedish cohort, while low-fat dairy showed no association. Associations were strongest for vascular dementia and among APOE ε4 non-carriers, with findings remaining observational.

23 Dec 2025

Simple blood test maps hidden Alzheimer’s disease changes

This population-based study used plasma pTau217 to estimate how common Alzheimer’s disease neuropathological changes are across age and cognitive status in a Norwegian community cohort. Prevalence rose steeply with age and was strongly associated with APOE ε4 genotype, education level, and kidney function, with implications for future use of blood biomarkers in clinical practice.

21 Dec 2025

Southeast Asia's first consortium launched to tackle dementia

Nanyang Technological University, Singapore (NTU Singapore) is leading 24 clinicians from the region and beyond to set up Southeast Asia's first consortium dedicated to tackling dementia.

28 Nov 2025

Shared genetic roots between delirium and Alzheimer’s disease

This study reveals genetic and proteomic risk factors for delirium, offering insights into its etiology and potential biomarkers for prediction and prevention.

26 Nov 2025

Hearing loss emerges as a key early warning sign for Alzheimer disease

Hearing loss also predicts a significantly higher risk of dementia, especially in APOE ε4 carriers, highlighting its value as an early risk marker.

23 Nov 2025

Midlife exercise cuts dementia risk by up to 45 percent, new study shows

Higher physical activity in midlife and late life is linked to a substantially lower risk of all-cause and Alzheimer’s dementia. Midlife benefits are strongest for moderate or heavy activity, while late-life activity is protective across all intensity levels.

20 Nov 2025

Clogged brain drains may signal early Alzheimer's risk

"Drains" in the brain, responsible for clearing toxic waste in the organ, tend to get clogged up in people who show signs of developing Alzheimer's disease, a study by researchers from Nanyang Technological University, Singapore (NTU Singapore) has discovered.

19 Nov 2025

Switching APOE4 to APOE2 in adult mice reduces Alzheimer’s pathology and improves memory

Replacing APOE4 with APOE2 in adult mice rapidly reshapes brain lipids and gene expression, even after development is complete. This switch, especially when targeted to astrocytes, reduces amyloid burden, dampens gliosis, and improves associative memory despite E2-like peripheral lipid risks.

12 Nov 2025