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Compound PF-04457845 slows motor decline in ALS mouse models

Amyotrophic lateral sclerosis (ALS) is a severe neurological disease that destroys nerve cells responsible for muscle movement.

28 Aug 2026

Researchers develop mild skeletal editing method for medicinal chemistry

Researchers at Ritsumeikan University report a halogen-guided method for transforming accessible hydroxycoumarins into coumaranones, valuable heterocyclic structures in medicinal chemistry.

27 Aug 2026

Phytoene in tomatoes may help protect against fatty liver disease

New study suggests a lesser-known compound in tomatoes may help protect against fatty liver disease, which affects more than 1 in 3 American adults.

26 Aug 2026

China faces rising lung cancer deaths driven by aging population

Lung cancer is the leading cause of cancer-related death both globally and in China, accounting for roughly 40% of the world's lung cancer deaths in 2022—a disproportionate burden given that China represents about 18% of the global population.

26 Aug 2026

New APIs extend Wiley's gold-standard spectral data and analytical intelligence directly into lab, vendor, and platform workflows

Wiley, a global leader in authoritative content and research intelligence, today announced the launch of its spectral analysis application programming interface (API) portfolio, providing users with a new, faster way to access its trusted spectral data, analytical algorithms, and predictive models–within their own workflows.

From John Wiley and Sons - Scientific Publishers 26 Aug 2026

From caffeine to trigonelline, coffee has surprising links to muscle biology

A scoping review of 54 studies found that coffee and several coffee-derived bioactive compounds influence pathways linked to skeletal muscle metabolism, including insulin signaling, mitochondrial function, oxidative stress, inflammation, glucose uptake, and protein turnover. Human studies reported associations with greater muscle mass and lower frailty or functional impairment, but most evidence remains observational or preclinical and cannot establish causality.

25 Aug 2026

UC Berkeley researchers find new potential treatment for obesity and diabetes

Over the past five years, medications called GLP-1s have revolutionized the treatment of metabolic disorders like obesity, diabetes and fatty liver diseases.

21 Aug 2026

Review outlines how SIRT3 protein regulates global metabolic disorders

A comprehensive review published in Engineering systematically outlines the regulatory capacity of silent information regulator 3 (SIRT3), a mitochondrial deacetylase termed the "head goose molecule", and its negentropic mechanism for intervening global metabolic disorders including type 2 diabetes, obesity, and steatotic liver disease.

21 Aug 2026

Study shows how prostate tumors rewire metabolism to resist therapy

Prostate tumors can rewire amino acid metabolism to override the normal brakes on cholesterol production, a process that may fuel hormone therapy resistance, according to a study by Weill Cornell Medicine investigators.

20 Aug 2026

AI-driven drug-target interaction prediction moves toward real-world workflows

Drug-target interaction prediction can help researchers explain mechanisms of action, identify candidate targets, reposition existing medicines and prioritize compounds before costly laboratory work.

20 Aug 2026

$Pomegranate-derived compound shows promise against preserved ejection fraction heart failure$

Pomegranate-derived compound shows promise against preserved ejection fraction heart failure

A compound produced in the body after eating pomegranates improves heart function by up to 80% in a type of heart failure with limited treatment options.

19 Aug 2026

World's largest single-site study maps brain changes under psilocybin

A landmark five-year study by Monash University has found psychedelics reorganise brain patterns, giving clinicians powerful new insights into their therapeutic potential.

19 Aug 2026

Dual-action compounds show promise against aggressive cancer and infections

Cancer patients often face more than the disease itself. Their treatment is frequently complicated by infections and other health conditions, meaning they may need to take several different medications at once.

18 Aug 2026

Polydatin reduces ulcerative colitis by regulating intestinal immune cells

Ulcerative colitis (UC) is a chronic inflammatory bowel disease in which recurrent intestinal inflammation can be difficult to control over the long term.

17 Aug 2026

New vaccination approach turns mosquito bites into immunity boosters

Researchers from WEHI (Melbourne, Australia) have discovered a new way to help prevent malaria that could one day transform mosquito bites from a source of deadly infection into immunity boosters against the disease.

13 Aug 2026

Natural gut molecule could strengthen chickens' immune response against bacterial infections

A naturally occurring gut molecule that could strengthen chickens' immune response against a wide range of bacterial infections, has been identified by University of Bristol-led research.

12 Aug 2026

Mitochondrial rewiring may explain why orthoflaviviruses harm humans but persist in mosquitoes

Orthoflaviviruses reshape mitochondrial structure, metabolism, redox signaling, and quality control differently across human and mosquito models, helping explain their contrasting infection outcomes. The review highlights mitochondrial pathways that may support acute cellular damage in vertebrates but persistent, non-lethal infection in mosquitoes, pointing to potential antiviral targets.

12 Aug 2026

Insilico Medicine nominates powerful oral drug candidate for the management of heart risks

Insilico Medicine, a clinical-stage generative artificial intelligence (AI)-driven drug discovery company, today announced the nomination of ISM0900, a potent, AI-driven, highly selective, orally available small molecule inhibitor of lipoprotein(a), or Lp(a), as a preclinical candidate (PCC) for the management of cardiovascular risks.

12 Aug 2026

CN Bio awarded Innovate UK grant to reduce animal use in pharmacokinetic studies

CN Bio, a leading provider of Organ-on-a-chip (OOC) Systems and solutions that accelerate drug discovery and development workflows, today announced it has been awarded £180 k grant funding from Innovate UK.

From CN Bio 12 Aug 2026

Aston University study reveals how mānuka honey fights antibiotic resistance

New research at Aston University has shown that a variety of compounds is responsible for the antimicrobial action of mānuka honey, not just the sugar content and methylglyoxal (MGO) alone, as previously thought.

11 Aug 2026