Glomerulus News and Research

RSS

Glomeruli are at the heart of renal function, and yet are only part of an intact nephron. They are of irreplaceable value in maintaining homeostasis.

High dose B-vitamin therapy slows progression of diabetic nephropathy: Study

Patients with diabetic nephropathy (kidney disease caused by diabetes) who received high dose B-vitamin therapy experienced a more rapid decline in kidney function and had a higher rate of heart attack and stroke than patients who received placebo, according to a study in the April 28 issue of JAMA.

28 Apr 2010

Investigators identify new disease mechanism and therapeutic approach for lupus kidney disease

Investigators have identified a new disease mechanism and therapeutic approach for a type of advanced kidney disease that is a common cause of complications in patients with lupus. The

27 Jan 2010

Dapagliflozin trial results indicate improvement in key glycemic measures in treatment-naive type 2 diabetes

Findings published in Diabetes Care from a 12-week, Phase IIb dose-ranging study showed that dapagliflozin, a novel, selective, sodium glucose co-transporter2 (SGLT2) inhibitor, produced clinically meaningful reductions across all key glycemic measures studied [glycosylated hemoglobin level (HbA1c), fasting plasma glucose (FPG), and postprandial plasma glucose (PPG)] in treatment-naive type 2 diabetes patients, compared to placebo.

29 Mar 2009

Neural mapping paints a haphazard picture of odor receptors

Despite the striking aromatic differences between coffee, peppermint, and pine, a new mapping of the nose's neural circuitry suggests a haphazard patchwork where the receptors for such disparate scents are as likely as not to be neighbors.

3 Feb 2009

Smell experience during critical period alters brain

Unlike the circuitry of the visual system, that of the olfactory system was thought to be hardwired: Once the neurons had formed, no amount of sensory input could change their arrangement.

5 Dec 2007

New cell-based targets for treating autoimmune inflammatory diseases

Patients with systemic autoimmune diseases such as lupus and rheumatoid arthritis (RA) often suffer loss of kidney function.

31 Aug 2006

New findings help researchers revise models of mammalian sense of smell

In a mouse model, University of Pennsylvania School of Medicine researchers discovered that olfactory sensory neurons expressing the same receptor responded to a specific odor with an array of speeds and sensitivities, a phenomenon previously not detected in the mammalian sense of smell.

12 Feb 2006