Hookworm News and Research

RSS

Hookworm infections in humans are caused by two important species of nematode parasites (a type of a roundworm), Ancylostoma duodenale and Necator americanus.

HOOKVAC consortium awarded grant to develop, test vaccine for human hookworm

The HOOKVAC consortium, led by the Academic Medical Center at the University of Amsterdam, today announced it has been awarded a grant of six million Euros from the European Commission FP7 programme to expand the Sabin Vaccine Institute Product Development Partnership’s (Sabin PDP) work to develop and test a vaccine for human hookworm, a disease that infects 600-700 million of the world’s poorest people.

27 Sep 2013

HOOKVAC consortium to begin first clinical testing of human hookworm vaccine in West Africa

The HOOKVAC consortium, led by the Academic Medical Center (AMC) at the University of Amsterdam, today announced it has been awarded a grant of six million Euros from the European Commission FP7 programme to expand the Sabin Vaccine Institute Product Development Partnership's (Sabin PDP) work to develop and test a vaccine for human hookworm, a disease that infects 600-700 million of the world's poorest people.

27 Sep 2013

Researchers find parasitic worms limit effects of autoimmune and other diseases

If the idea of hookworms makes you shudder, consider this: Those pesky intestinal parasites may actually help your body ward off other infections, and perhaps even prevent autoimmune and other diseases.

31 Aug 2013

Bacterial crystal protein could be safe, inexpensive treatment for parasitic worms in humans

A benign crystal protein, produced naturally by bacteria and used as an organic pesticide, could be a safe, inexpensive treatment for parasitic worms in humans and provide effective relief to over a billion people around the world.

24 Jul 2013

Certain varieties of clay have ability to kill MRSA, says ASU researcher

In the race to protect society from infectious microbes, the bugs are outrunning us. The need for new therapeutic agents is acute, given the emergence of novel pathogens as well as old foes bearing heightened antibiotic resistance.

20 May 2013

Cell phone microscope can detect intestinal worm infections in children

Scientists working in rural Tanzania have used a simple US$8 glass lens, a strip of double-sided tape, and a cheap flashlight to convert an Apple iPhone into a field microscope that can successfully detect intestinal worm infections in children, according to a study published online today by the American Journal of Tropical Medicine and Hygiene.

12 Mar 2013

Co-infection itself a very important risk factor among school-aged children in Tanzania

The new study analyses data from school aged children in Tanzania infected with the most common forms of worms. It was found that infection by one parasitic species actually changes the risk of catching another, over and above other risk factors.

11 Jan 2013

Global development partners meet in Washington to discuss NTD control efforts

"'Hundreds of millions of children and adults in Africa live at risk of disfigurement, impaired development, blindness, and even death from seven major preventable so-called neglected tropical diseases [NTDs], including river blindness, elephantiasis, trachoma, and various types of intestinal parasites,' said World Bank President Jim Yong Kim at the opening of a November 16-18 conference in Washington D.C.: Uniting to Combat NTDs: Translating the London Declaration into Action," the World Bank reports in an article on its webpage.

20 Nov 2012

Sabin initiates Part II of Na-GST-1 vaccine Phase I hookworm trial

The Sabin Vaccine Institute (Sabin) today announced the start of Part II of its Phase I clinical trial of the Na-GST-1 vaccine candidate, marking another major milestone in the progress toward developing a human hookworm vaccine.

6 Nov 2012

Train-Match-Fit-Streamline uses 11 factors to quickly pair likely drugs and diseases

With the cost of putting a single new drug on the pharmacy shelves topping a staggering $1 billion, scientists are reporting development of a way to determine if an already-approved drug might be used to treat a different disease. The technique for repurposing existing medicines could cut drug development costs and make new medicine available to patients faster, they report in ACS' Journal of Medicinal Chemistry.

2 Aug 2012

Sabin initiates novel human hookworm vaccine Phase 1 clinical trial

Today, the Sabin Vaccine Institute, in partnership with the George Washington University and the Children's National Medical Center, began vaccinating participants for a Phase 1 clinical trial of a novel human hookworm vaccine.

14 Jun 2012

Clinical and Translational Science Institute-Children's National awards pilot grant to GW researchers

GW researchers in the School of Medicine, Jeffrey M. Bethony, Ph.D., Associate Professor of Microbiology, Immunology, and Tropical Medicine and David Diemert, M.D., FRCP(C), Associate Research Professor of Microbiology, Immunology, and Tropical Medicine and Director of Clinical Trials for the Sabin Vaccine Institute's Product Development Partnership (PDP), have been awarded a Pilot Grant from the Clinical and Translational Science Institute-Children's National.

25 Apr 2012

Shoes play vital role in protecting children's health, development

"As we have seen in our work in Haiti and around the world, shoes are a first level of defense when it comes to good health, and are a great complement to the Neglected Tropical Disease (NTD) Control program IMA World Health implements in Haiti," Rick Santos, president and CEO of IMA World Health, writes in the Huffington Post Blog, commemorating One Day Without Shoes, observed on Tuesday.

12 Apr 2012

Clemson researcher to continue African sleeping sickness study

Clemson University researcher James Morris received a $360,079 competitive renewal grant from the National Institutes of Health to continue his study of Trypanosoma brucei, the single-celled parasite that causes African sleeping sickness.

3 Apr 2012

Parasitic worms could offer new treatment hope for MS patients

Parasitic worms could offer a new treatment hope for patients suffering from the autoimmune disease multiple sclerosis, scientists believe.

1 Mar 2012

World-renowned researcher to address NTDs at UH, Feb. 10

Dr. Peter J. Hotez, an internationally recognized clinician and investigator of neglected tropical diseases and vaccine development, will be giving a lecture at the University of Houston (UH) from 3 to 4 p.m. Friday, Feb. 10. Hotez is one of many prominent scientists with broad appeal who will be hosted by UH in support of the university's health initiative. The talk is free and open to the public.

8 Feb 2012

Access to, use of sanitation systems cuts odds of worm infection in half, study review shows

When sanitation systems are available and used, the odds of contracting one of a group of diseases, known as soil-transmitted helminths (STH), is cut in half, according to a systemic review and meta-analysis published this week in PLoS Medicine, Examiner.com reports (Herriman, 1/25).

30 Jan 2012

Intestinal worm infections may not be bad

Intestinal worm infections may not be all bad, according to a new study by William C. Gause, PhD, and colleagues at UMDNJ- New Jersey Medical School. The researchers have found cytokines that help oust intestinal worm infections in mice also soothe associated lung injury and inflammation.

11 Jan 2012

Researchers to begin drug development projects for rare and neglected diseases

Researchers will begin drug development projects for rare and neglected diseases that include potential treatments for a musculoskeletal disorder, a cognitive dysfunction disorder, a virus that affects the central nervous system of newborns, a parasitic worm infection, a form of muscular dystrophy and a rare lung disease.

16 Nov 2011

Developing new antipoverty vaccines may eliminate world's neglected diseases, says Sabin president

Despite significant advancements in increasing distribution and development of vaccines against childhood killer diseases - including pneumococcal disease, rotavirus, and Haemophilus influenzae Type B - global efforts to reduce the burden of infection from neglected tropical diseases (NTDs) has greatly lagged, argues Sabin Vaccine Institute (Sabin) President Dr. Peter Hotez in an article for the June edition of Health Affairs.

23 Jun 2011