Large Intestine News and Research

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He went in for a colonoscopy. The hospital charged $19,000 for two.

Tom Contos is an avid runner. When he started experiencing rectal bleeding in March, he thought exercise could be the cause and tried to ignore it. But he became increasingly worried when the bleeding continued for weeks.

19 Dec 2024

Gut microbes may have helped human ancestors develop larger brains

Brain tissue is among the most energetically costly in the body, and as a result, larger-brained mammals require more energy to support brain growth and maintenance.

3 Dec 2024

Parkinson's disease drug disrupts the gut microbiome by inducing iron deficiency

In a groundbreaking new study, conducted within the framework of the FWF-funded Cluster of Excellence "Microbiomes drive Planetary Health", scientists from the University of Vienna, in collaboration with the University of Southampton, Aalborg University and Boston University, have revealed that the widely prescribed Parkinson's disease drug entacapone significantly disrupts the human gut microbiome by inducing iron deficiency.

22 Nov 2024

New atlas maps 1.6 million human gut cells in unprecedented detail

The most comprehensive cell map of the human gut to date has been created by combining spatial and single-cell data from 1.6 million cells.

21 Nov 2024

Research sheds light on Salmonella’s ability to escape gut defenses

A new UC Davis Health study has uncovered how Salmonella bacteria, a major cause of food poisoning, can invade the gut even when protective bacteria are present.

15 Nov 2024

Weighing screening options for colorectal cancer in a changing landscape

Newly available blood tests to screen for colorectal cancer sound far more appealing than a standard colonoscopy. Instead of clearing your bowels and undergoing an invasive procedure, the tests require only a simple blood draw. But are the tests effective?

28 Oct 2024

Study sheds new light on p53 tumor suppressor gene's role in ulcerative colitis

Researchers in the lab of Michael Sigal at the Max Delbrück Center and Charité – Universitätsmedizin Berlin have elucidated the role of the p53 gene in ulcerative colitis.

26 Oct 2024

Tea, coffee, and fruits found to be top contributors to polyphenol intake in study exploring GI inflammation in healthy adults

Researchers estimated dietary polyphenol intake in healthy adults and investigated its associations with gastrointestinal and systemic inflammation markers.

21 Aug 2024

Porcine study reveals meurotoxic and pro-inflammatory effects of microplastics on enteric nervous system

Researchers investigates the effects of polyethylene terephthalate microplastics on the neuronal population in the porcine jejunum.

18 Jul 2024

Dietary fiber promotes beneficial conversion of tryptophan by gut bacteria

We get healthy dietary fibres from consuming fruits, vegetables, and whole grains. But why are the fibres so good for us? A team of researchers has discovered that dietary fibres play a crucial role in determining the balance between the production of healthy and harmful substances by influencing the behavior of bacteria in the colon.

26 Jun 2024

Bile acids: Balancing digestive health and liver toxicity

Bile acids are essential molecules the liver produces that play a critical role in digestion. They help us absorb fat-soluble vitamins and cholesterol from our food.

6 Jun 2024

Clinical trial in Seattle aims to transform treatment approaches for pediatric IBD

With pediatric inflammatory bowel disease (IBD) diagnoses on the rise globally, a clinical trial in Seattle aims to transform treatment approaches through deep molecular profiling.

14 May 2024

Research uncovers Blautia bacteria's crucial role in gut health and disease protection

A low-fiber “Western diet” causes damage to the protective mucus barrier in the gut, and such damage can increase the risk of inflammation and infection.

29 Apr 2024

Combining blood pressure drug with dietary-resistant starch may help stave off diabetic kidney disease

Combining a low dose of blood pressure medication with a higher intake of dietary-resistant starch might help stave off diabetic kidney disease, according to results from a new animal study.

7 Apr 2024

Immune responses in mesenteric lymph nodes improve understanding of Crohn's disease

Crohn's disease is a chronic inflammatory bowel disease that is sometimes insufficiently controlled by immunosuppressive therapies with a subsequent need for surgical removal of affected bowel segments.

25 Mar 2024

Resistant starch diet proves a game changer for weight loss and diabetes control

Supplementation with resistant starch leads to weight loss and improved insulin sensitivity by altering the gut microbiome and increasing secondary bile acids, according to a recent study in Nature Metabolism.

27 Feb 2024

Research unveils major discovery in gut-brain axis communication

The mechanisms by which antidepressants and other emotion-focused medications work could be reconsidered due to an important new breakthrough in the understanding of how the gut communicates with the brain.

26 Feb 2024

New study advances understanding of prebiotics in nutrition and gut health

A groundbreaking study led by David Berry and Alessandra Riva from the Centre for Microbiology and Environmental Systems Science (CeMESS) at the University of Vienna has significantly advanced our understanding of prebiotics in nutrition and gut health.

14 Dec 2023

Brazzein and monellin: Safe alternatives to sugar, new research confirms

Toxicity assessments of monellin and brazzein.

10 Nov 2023

GLP-1 agonists linked to higher risk for gastrointestinal complications

They're being hailed as an effective way to lose weight, but diabetes drugs like Ozempic may come with a heightened risk of severe gastrointestinal problems.

5 Oct 2023