Leptin News and Research

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Leptin is a 16 kDa protein hormone that plays a key role in regulating energy intake and energy expenditure, including appetite and metabolism. It is one of the most important adipose derived hormones. The ''Ob(Lep)'' gene (Ob for obese, Lep for leptin) is located on chromosome 7 in humans.

Small weight loss leads to big gains in heart health

Even without weight loss, healthy lifestyle changes enhance heart health. This study highlights the importance of habits for cardiometabolic improvement.

9 Jun 2025

Healthy diet improves metabolism even without weight loss

Nearly one-third of people who adopted and adhered to a healthy diet did not lose any weight, but still reaped many health benefits, according to a new study led by researchers at Harvard T.H. Chan School of Public Health and Ben Gurion University, Israel.

6 Jun 2025

MRI scans reveal why young women face higher risk for eating disorders

Advanced high-field MRI reveals distinct microstructural changes in hypothalamic subregions of young women with anorexia nervosa and obesity. These alterations may underlie increased vulnerability to eating disorders and point toward new neurobiological treatment targets.

26 May 2025

Eating kombu daily enhances gut health and heart markers in men

A 12-week randomized trial found that daily intake of boiled kombu (Laminaria japonica) powder reduced body fat and raised adiponectin in Japanese men, while improving blood pressure and gut microbiota in both sexes. No significant effects were seen in women for body fat reduction or adiponectin.

20 May 2025

Lipid accumulation levels reveal hidden osteoporosis risk

Researchers investigate the use of lipid accumulation products as a predictor of osteoporosis.

14 May 2025

Once-daily oral treatment shows positive results in first human study for obesity treatment

A first-in-human study of an investigational once-daily oral treatment for obesity (SYNT-101) demonstrated positive preliminary data for the safe and effective redirection of nutrient absorption into the lower intestine, the weight loss and metabolic management mechanism behind gastric bypass surgery.

14 May 2025

Collagen protein bars show promise for safe and effective weight loss

Research being presented at this year's European Congress on Obesity (ECO 2025) and published in the journal Nutrients indicates that collagen could be a safe and effective weight-loss supplement.

12 May 2025

Study shows brain estrogen directly regulates appetite in mice

Researchers in Japan found that estrogen produced within the brain, called neuroestrogen, suppresses appetite and reduces body weight in mice by enhancing MC4R expression. The study also showed that neuroestrogen boosts leptin sensitivity, suggesting new targets for obesity treatment.

2 May 2025

High fructose diets impair brain function and appetite control, study shows

Review highlights how excessive fructose intake disrupts brain energy balance, appetite regulation, and cognitive function. Processed sources, such as sugary drinks, may overwhelm metabolic pathways and induce neuroinflammation, particularly during adolescence.

30 Apr 2025

Monell study offers renewed hope for people living with Bardet-Biedl Syndrome

A Monell Chemical Senses Center study published this week in the Journal of Clinical Investigation offers renewed hope for individuals living with Bardet-Biedl Syndrome (BBS), a rare genetic disorder characterized by early-onset obesity, compulsive eating, and cognitive impairments.

18 Apr 2025

Unveiling leptin signaling in the DMH for metabolic effects

Scientists at Pennington Biomedical Research Center have gained greater clarity in the brain regions and neurons that control metabolism, body temperature and energy use.

27 Mar 2025

Study sheds light on why women experience chronic pain more than men

A new study led by University of Calgary professor Dr. Tuan Trang, PhD, may help to explain why there is an over-representation of women experiencing chronic pain compared to men.

18 Mar 2025

Is red meat good or bad for you? Study explains how amino acids shape the answer

Researchers at Texas Tech University reviewed how red meat proteins and amino acids affect human health, weighing both benefits and risks. Their findings highlight that while red meat provides vital nutrients, overconsumption and poor preparation methods can increase disease risk.

10 Mar 2025

Research reveals genetic connection between obesity in dogs and humans

Researchers studying British Labrador retrievers have identified multiple genes associated with canine obesity and shown that these genes are also associated with obesity in humans.

6 Mar 2025

Researchers discover neural mechanism behind leptin resistance and a way to reverse it

Worldwide obesity rates have more than doubled since 1990, with nearly a billion people now falling into the category.

4 Mar 2025

Neuroestrogens likely contribute to appetite regulation

Although a woman's ovaries produce the most estrogen, various types of estrogen are also synthesized throughout different tissues in the body, including the brain's neurons.

19 Feb 2025

New review maps the impact of reproductive hormones on neurological health

A comprehensive review published today in Brain Medicine by leading neuroendocrinologist Professor Hyman M. Schipper from McGill University's Department of Neurology and Neurosurgery maps out the extensive influence of reproductive hormones on neurological health and disease.

18 Feb 2025

How exercise affects appetite in obese men

Researchers examine how appetite-associated factors impact appetite perception in obese males.

3 Feb 2025

Weekly diabetes injection could replace daily shots for lipodystrophy patients

Rutgers Health researchers have found that a weekly injection of diabetes medication could replace painful daily hormone shots for people with a rare genetic form of lipodystrophy that leaves patients with almost zero fat tissue, according to a study in The New England Journal of Medicine.

29 Jan 2025

Could mulberry extract be the key to fighting obesity-induced reproductive dysfunction?

Research indicates mulberry extract's efficacy in addressing obesity-related male infertility, enhancing reproductive outcomes through bioactive compounds.

16 Jan 2025