Prostate Specific Antigen News and Research

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Genetic test outperforms PSA and MRI in spotting deadly prostate cancer early

A UK study found that using a polygenic risk score to identify men at highest genetic risk of prostate cancer significantly improved detection of clinically important disease. This approach caught aggressive cancers that standard PSA and MRI screening would have missed.

10 Apr 2025

Laser-based infrared molecular fingerprinting detects common cancers

Cancer diagnoses traditionally require invasive or labor-intensive procedures such as tissue biopsies.

9 Apr 2025

World first as MHRA approves trofolastat for diagnostic imaging of prostate cancer in men

The Medicines and Healthcare products Regulatory Agency (MHRA) has approved trofolastat (RoTecPSMA), the first prostate-specific membrane antigen (PSMA)-targeting product authorised for use with technetium-99m to detect cancerous lesions in men with prostate cancer.

31 Mar 2025

Aquablation shows promise for treating enlarged prostate with fewer side effects

Using a high-pressure water jet to operate on an enlarged prostate can better preserve the ability to ejaculate, compared with standard laser surgery, finds research.

22 Mar 2025

Avoiding prostate cancer screening increases risk of death

Men who consistently avoid prostate cancer screening appointments face a disproportionately higher risk of dying from the disease, finds research identifying a new high-risk group.

20 Mar 2025

Current PSA monitoring guidelines may lead to overtreatment after prostate surgery

After surgical removal of the prostate to treat prostate cancer, clinicians monitor Prostate Specific Antigen (PSA) levels.

13 Mar 2025

Study challenges role of BRCA1 mutation in prostate cancer initiation

Mutations in the BRCA1 gene that are either inherited (germline) or acquired (somatic) might not be key to the initiation of prostate cancer, as previously thought, suggests the first study of its kind, published online in the open access journal BMJ Oncology.

24 Feb 2025

Study finds variations in prostate cancer detection across GP practices

A largescale study has found huge variation between GP practices on whether they are likely to pick up prostate cancer using a blood test.

24 Feb 2025

Prostate cancer incidence rises in California following screening guideline change

Following a change in screening guidelines, the incidence went up across the state, even more than it has nationally.

3 Feb 2025

Study highlights potential of genomic tests for early stage prostate cancer

A new review led by researchers at Moffitt Cancer Center assessed how three genomic tests - Decipher, Oncotype DX Genomic Prostate Score (GPS) and Prolaris - can help doctors make better decisions about how to treat patients with early stage prostate cancer.

24 Jan 2025

Expert consensus provides unified framework for prostate cancer care in China

While prostate cancer is becoming more prevalent among middle-aged and elderly men in China, clinical practice still faces considerable challenges due to the lack of unified guidelines and high-level evidence on several aspects of patient care.

20 Jan 2025

Prostate cancer vaccines: Progress, challenges, and future directions

Prostate cancer vaccines, including dendritic and peptide types, offer hope for improved treatments, but face hurdles in clinical effectiveness and validation.

11 Dec 2024

45 years of progress: Prevention and screening avert millions of cancer deaths

Research shows that cancer prevention and screening efforts prevented 5.94 million deaths across five major cancer types, highlighting their critical role.

6 Dec 2024

Demographic and socioeconomic factors impact prostate cancer detection in Ireland

Recent findings from a study on prostate cancer in Ireland reveal diagnosis disparities, especially in urban areas and middle socioeconomic groups.

28 Nov 2024

Study highlights long-term risks of prostate cancer treatment

The risks of adverse effects and complications from treatment for prostate cancer are substantial and continue for years after treatment ends.

7 Nov 2024

AI-powered MRI predicts outcomes in prostate cancer

Researchers determine whether artificial intelligence-based MRI data could predict prostate cancer patient outcomes.

6 Nov 2024

AI model could help clinicians to understand prostate tumor's aggressiveness

Prostate cancer is the second most common cancer in men, and almost 300,000 individuals are diagnosed with it each year in the U.S.

29 Oct 2024

Early blood test can predict treatment response and survival prospects in metastatic prostate cancer

A blood test, performed when metastatic prostate cancer is first diagnosed, can predict which patients are likely to respond to treatment and survive the longest.

7 Oct 2024

Study suggests overdiagnosis of prostate cancer across Europe

Rates of prostate cancer across Europe since 1980 are "indicative of overdiagnosis", say researchers in a study published by The BMJ today.

4 Sep 2024

Olaparib effective against BRCA2-mutated prostate cancer

The anti-cancer drug olaparib may be effective in treating biochemically recurrent prostate cancer without accompanying hormone therapy for men who have mutations in genes such as BRCA2, according to results of a phase II clinical trial of 51 patients conducted at the Johns Hopkins Kimmel Cancer Center and three other sites.

23 Aug 2024